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Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
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Jayong Chung
Published/Copyright:
October 21, 2009
Abstract
Background: Glutathione S-transferase (GST) enzymes are critical for detoxifying reactive oxygen species (ROS) and their products which have been implicated in the pathology of inflammatory diseases such as atopic dermatitis (AD).
Methods: We investigated the effects of genetic polymorphisms of GST on the risk of AD in preschool age children. Biomarkers for oxidative stress were also evaluated with respect to GST genotype.
Results: The GSTP1 Val105 allele was significantly associated with an increased risk of AD [odds ratio (OR)=1.62, p<0.05]. The combination of the GSTP1 Val105 allele and the GSTT1 null genotype further increased this risk by 2.3-fold (p<0.01). No association was observed for the GSTM1 null or GSTT1 null genotype alone. In children with AD, blood total antioxidant capacity was significantly less (p<0.001), while malondialdehyde was higher (p=0.12). Children with the GSTP1 Val105 allele had significantly lower concentrations of erythrocyte glutathione compared to GSTP1 Ile/Ile homozygotes (p=0.03).
Conclusions: Our study suggests that the GSTP1 Val105 allele is an important determinant of susceptibility to AD in preschool age children and increased oxidative stress may play a role in the pathogenesis of AD.
Clin Chem Lab Med 2009;47:1475–81.
Keywords: atopic dermatitis; glutathione-S-transferase; oxidative stress; polymorphism; preschool age children
Received: 2009-4-5
Accepted: 2009-8-5
Published Online: 2009-10-21
Published in Print: 2009-12-01
©2009 by Walter de Gruyter Berlin New York
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Keywords for this article
atopic dermatitis;
glutathione-S-transferase;
oxidative stress;
polymorphism;
preschool age children
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