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Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis

  • Andrea Tesija Kuna , Lovro Lamot , Marijana Miler , Miroslav Harjacek , Ana-Maria Simundic and Nada Vrkic
Published/Copyright: October 21, 2009
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Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 47 Issue 12

Abstract

Background: The goal of the study was to assess the presence of antibodies to mutated citrullinated vimentin (anti-MCV) and cyclic citrullinated peptides (anti-CCP) in patients with juvenile idiopathic arthritis (JIA) compared with patients with other juvenile onset rheumatic diseases.

Methods: The study included 56 patients who fulfilled the International League of Associations for Rheumatology (ILAR) classification criteria for JIA, and 17 control patients with other juvenile onset rheumatic diseases. Data on six core outcome variables and the Sharp score were collected for patients with JIA. Sera and synovial fluid, if available, were tested for anti-CCP and anti-MCV antibodies using a commercial enzyme-linked immunosorbent assay (ELISA).

Results: Anti-MCV antibodies were positive in 3/56 (5.4%) and anti-CCP in 1/56 (1.8%) of patients with JIA. Two out of three anti-MCV positive patients (one of them also anti-CCP positive) were found to be rheumatoid factor (RF)-positive with polyarticular disease. Within the control group, anti-MCV was positive in 4/17 (23.5%) patients, while anti-CCP positivity was not observed. No correlation between anti-MCV with anti-CCP antibody levels was found for any of the six core outcome variables or for the adapted Sharp score.

Conclusions: Our results show that antibodies targeting citrullinated proteins are not a useful diagnostic marker for JIA, but can indicate severe patterns of disease in JIA.

Clin Chem Lab Med 2009;47:1525–30.

Keywords: antibodies to mutated citrullinated vimentin; citrullinated proteins; juvenile idiopathic arthritis
Corresponding author: Andrea Tesija Kuna, PhD, University Department of Chemistry, “Sestre Milosrdnice” University Hospital, Vinogradska 29, 10000 Zagreb, Croatia Phone/Fax: +385 1 3768 280,
Received: 2009-5-25
Accepted: 2009-7-10
Published Online: 2009-10-21
Published in Print: 2009-12-01

©2009 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2009.288
Keywords for this article
antibodies to mutated citrullinated vimentin; citrullinated proteins; juvenile idiopathic arthritis

Articles in the same Issue

  1. Review
  2. Multiple gene interaction and modulation of hemostatic balance
  3. Minireview
  4. Appropriate utilization of clinical laboratory tests
  5. Genetics and Molecular Diagnostics
  6. Quantitation of RNA decay in dried blood spots during 20 years of storage
  7. ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study
  8. Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
  9. Haplotype-based association of regulator of G-protein signaling 5 gene polymorphisms with essential hypertension and metabolic parameters in Chinese
  10. A new automated human leukocyte antigen genotyping strategy to identify DR-DQ risk alleles for celiac disease and type 1 diabetes mellitus
  11. General Clinical Chemistry and Laboratory Medicine
  12. Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults
  13. Screening for M-proteinemia: serum protein electrophoresis and free light chains compared
  14. Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke
  15. Salivary neuron specific enolase: an indicator for neuronal damage in patients with ischemic stroke and stroke-prone patients
  16. Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis
  17. Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children
  18. Nucleated red blood cells and soluble transferrin receptor in thalassemia syndromes: relationship with global and ineffective erythropoiesis
  19. Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever
  20. Preanalytical mistakes in samples from primary care patients
  21. Should kidney tubular markers be adjusted for urine creatinine? The example of urinary cystatin C
  22. Validation and Outcome Studies
  23. Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP)
  24. Development and validation of a liquid chromatography-tandem mass spectrometry assay for serum 25-hydroxyvitamin D2/D3 using a turbulent flow online extraction technology
  25. Letters to the Editor
  26. Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population
  27. Falsely elevated troponin I attributed to collection tubes using the Vitros ECiQ system
  28. Processing effects and storage conditions on A Disintegrin And Metalloprotease (ADAM12s), a maternal serum marker for adverse pregnancy outcome
  29. Serum γ-glutamyltransferase: linking together environmental pollution, redox equilibria and progression of atherosclerosis?
  30. The impact factor for evaluating scientists: the good, the bad and the ugly
  31. Acknowledgement
  32. Acknowledgement
  33. Contents
  34. Contents, Volume 47, 2009
  35. Author Index
  36. Author Index
  37. Subject Index
  38. Subject Index
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