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Multiple gene interaction and modulation of hemostatic balance

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Published/Copyright: October 13, 2009
Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 47 Issue 12

Abstract

Recent progress in the understanding of the pathophysiology of hemostasis has established that blood coagulation disorders causing bleeding or thrombosis often indicate a multi-casual nature in which the interaction between genetic and acquired factors plays a major mechanistic role. The interaction of two or more factors may attenuate clinical symptoms. However, a synergic worsening may also occur, resulting in a higher risk than expected from the combination of the separate effects. The role of genetic factors on the modulation of the phenotypic expression of coagulation disorders will be addressed in this review, with particular emphasis on the underlying pathogenic mechanisms and clinical implications.

Clin Chem Lab Med 2009;47:1455–60.

Keywords: bleeding; genotype; hemostatic balance; phenotype; thrombosis
Corresponding author: Massimo Franchini, Department of Pathology and Laboratory Medicine, Immunohematology and Transfusion Center, University Hospital of Parma, Italy
Received: 2009-7-29
Accepted: 2009-8-10
Published Online: 2009-10-13
Published in Print: 2009-12-01

©2009 by Walter de Gruyter Berlin New York

Articles in the same Issue

  1. Review
  2. Multiple gene interaction and modulation of hemostatic balance
  3. Minireview
  4. Appropriate utilization of clinical laboratory tests
  5. Genetics and Molecular Diagnostics
  6. Quantitation of RNA decay in dried blood spots during 20 years of storage
  7. ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study
  8. Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
  9. Haplotype-based association of regulator of G-protein signaling 5 gene polymorphisms with essential hypertension and metabolic parameters in Chinese
  10. A new automated human leukocyte antigen genotyping strategy to identify DR-DQ risk alleles for celiac disease and type 1 diabetes mellitus
  11. General Clinical Chemistry and Laboratory Medicine
  12. Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults
  13. Screening for M-proteinemia: serum protein electrophoresis and free light chains compared
  14. Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke
  15. Salivary neuron specific enolase: an indicator for neuronal damage in patients with ischemic stroke and stroke-prone patients
  16. Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis
  17. Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children
  18. Nucleated red blood cells and soluble transferrin receptor in thalassemia syndromes: relationship with global and ineffective erythropoiesis
  19. Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever
  20. Preanalytical mistakes in samples from primary care patients
  21. Should kidney tubular markers be adjusted for urine creatinine? The example of urinary cystatin C
  22. Validation and Outcome Studies
  23. Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP)
  24. Development and validation of a liquid chromatography-tandem mass spectrometry assay for serum 25-hydroxyvitamin D2/D3 using a turbulent flow online extraction technology
  25. Letters to the Editor
  26. Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population
  27. Falsely elevated troponin I attributed to collection tubes using the Vitros ECiQ system
  28. Processing effects and storage conditions on A Disintegrin And Metalloprotease (ADAM12s), a maternal serum marker for adverse pregnancy outcome
  29. Serum γ-glutamyltransferase: linking together environmental pollution, redox equilibria and progression of atherosclerosis?
  30. The impact factor for evaluating scientists: the good, the bad and the ugly
  31. Acknowledgement
  32. Acknowledgement
  33. Contents
  34. Contents, Volume 47, 2009
  35. Author Index
  36. Author Index
  37. Subject Index
  38. Subject Index
https://doi.org/10.1515/CCLM.2009.331
Keywords for this article
bleeding; genotype; hemostatic balance; phenotype; thrombosis

Articles in the same Issue

  1. Review
  2. Multiple gene interaction and modulation of hemostatic balance
  3. Minireview
  4. Appropriate utilization of clinical laboratory tests
  5. Genetics and Molecular Diagnostics
  6. Quantitation of RNA decay in dried blood spots during 20 years of storage
  7. ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study
  8. Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
  9. Haplotype-based association of regulator of G-protein signaling 5 gene polymorphisms with essential hypertension and metabolic parameters in Chinese
  10. A new automated human leukocyte antigen genotyping strategy to identify DR-DQ risk alleles for celiac disease and type 1 diabetes mellitus
  11. General Clinical Chemistry and Laboratory Medicine
  12. Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults
  13. Screening for M-proteinemia: serum protein electrophoresis and free light chains compared
  14. Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke
  15. Salivary neuron specific enolase: an indicator for neuronal damage in patients with ischemic stroke and stroke-prone patients
  16. Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis
  17. Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children
  18. Nucleated red blood cells and soluble transferrin receptor in thalassemia syndromes: relationship with global and ineffective erythropoiesis
  19. Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever
  20. Preanalytical mistakes in samples from primary care patients
  21. Should kidney tubular markers be adjusted for urine creatinine? The example of urinary cystatin C
  22. Validation and Outcome Studies
  23. Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP)
  24. Development and validation of a liquid chromatography-tandem mass spectrometry assay for serum 25-hydroxyvitamin D2/D3 using a turbulent flow online extraction technology
  25. Letters to the Editor
  26. Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population
  27. Falsely elevated troponin I attributed to collection tubes using the Vitros ECiQ system
  28. Processing effects and storage conditions on A Disintegrin And Metalloprotease (ADAM12s), a maternal serum marker for adverse pregnancy outcome
  29. Serum γ-glutamyltransferase: linking together environmental pollution, redox equilibria and progression of atherosclerosis?
  30. The impact factor for evaluating scientists: the good, the bad and the ugly
  31. Acknowledgement
  32. Acknowledgement
  33. Contents
  34. Contents, Volume 47, 2009
  35. Author Index
  36. Author Index
  37. Subject Index
  38. Subject Index
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