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Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children

  • Jianxin Li , Xin Lai , Cunliang Yan , Anping Xu , Liping Nie , Yu Zhou , Chaoyu Liao and Hanyun Ren
Published/Copyright: November 2, 2009
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Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 47 Issue 12

Abstract

Background: The concept of developmental hemostasis has been universally accepted. Physiological reference ranges for coagulation tests are available for infants and children of different ages. However, on Oriental children they are rare.

Methods: Results of preoperative activated partial thromboplastin time (APTT) in neonates, infants, children aged 1–18 years and adults with minor elective surgery in a university affiliated hospital were reviewed retrospectively. Plasma activity of factors VIII, IX, XI, XII (FVIII:C, FIX:C, FXI:C, FXII:C) and lupus anticoagulants (LAC) in 47 children with prolonged APTT and 34 adult controls were measured to investigate the causes of prolongation.

Results: Compared with adults, APTT values were prolonged significantly and were age-dependent in children, especially in neonates and infants aged 1–6 months. Mean values for FXII:C and FIX:C in children with prolonged APTT values were significantly lower than those in adults (p<0.001). Prolonged APTT values correlated negatively with FXII:C and FIX:C, and weakly with the LAC Screen ratio (LAC-SR) (r0.01=−0.808, –0.705 and 0.372, p=0.000, 0.000 and 0.001, respectively). There was weak negative correlation between FXII:C and LAC-SR (r0.01=−0.277, p=0.012). No significant correlation was seen between prolonged APTT values and FVIII:C or FXI:C.

Conclusions: APTT values change dynamically with age during childhood and display a distinct pattern of evolution in children. Lower values of FXII:C and FIX:C, and presence of LAC contribute to the prolongation of APTT values in Chinese children.

Clin Chem Lab Med 2009;47:1531–7.

Keywords: activated partial thromboplastin time; blood coagulation factor; developmental hemostasis; lupus anticoagulants
Corresponding author: Prof. Hanyun Ren, MD, PhD, Department of Hematology, Peking University First Hospital, No. 8, Xishiku Street, Beijing, 100034, China Phone: +86-10-66551122-5082, Fax: +86-10-66551811,
Received: 2009-6-18
Accepted: 2009-8-25
Published Online: 2009-11-2
Published in Print: 2009-12-01

©2009 by Walter de Gruyter Berlin New York

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  38. Subject Index
https://doi.org/10.1515/CCLM.2009.339
Keywords for this article
activated partial thromboplastin time; blood coagulation factor; developmental hemostasis; lupus anticoagulants

Articles in the same Issue

  1. Review
  2. Multiple gene interaction and modulation of hemostatic balance
  3. Minireview
  4. Appropriate utilization of clinical laboratory tests
  5. Genetics and Molecular Diagnostics
  6. Quantitation of RNA decay in dried blood spots during 20 years of storage
  7. ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study
  8. Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
  9. Haplotype-based association of regulator of G-protein signaling 5 gene polymorphisms with essential hypertension and metabolic parameters in Chinese
  10. A new automated human leukocyte antigen genotyping strategy to identify DR-DQ risk alleles for celiac disease and type 1 diabetes mellitus
  11. General Clinical Chemistry and Laboratory Medicine
  12. Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults
  13. Screening for M-proteinemia: serum protein electrophoresis and free light chains compared
  14. Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke
  15. Salivary neuron specific enolase: an indicator for neuronal damage in patients with ischemic stroke and stroke-prone patients
  16. Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis
  17. Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children
  18. Nucleated red blood cells and soluble transferrin receptor in thalassemia syndromes: relationship with global and ineffective erythropoiesis
  19. Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever
  20. Preanalytical mistakes in samples from primary care patients
  21. Should kidney tubular markers be adjusted for urine creatinine? The example of urinary cystatin C
  22. Validation and Outcome Studies
  23. Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP)
  24. Development and validation of a liquid chromatography-tandem mass spectrometry assay for serum 25-hydroxyvitamin D2/D3 using a turbulent flow online extraction technology
  25. Letters to the Editor
  26. Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population
  27. Falsely elevated troponin I attributed to collection tubes using the Vitros ECiQ system
  28. Processing effects and storage conditions on A Disintegrin And Metalloprotease (ADAM12s), a maternal serum marker for adverse pregnancy outcome
  29. Serum γ-glutamyltransferase: linking together environmental pollution, redox equilibria and progression of atherosclerosis?
  30. The impact factor for evaluating scientists: the good, the bad and the ugly
  31. Acknowledgement
  32. Acknowledgement
  33. Contents
  34. Contents, Volume 47, 2009
  35. Author Index
  36. Author Index
  37. Subject Index
  38. Subject Index
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