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Salivary neuron specific enolase: an indicator for neuronal damage in patients with ischemic stroke and stroke-prone patients

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Published/Copyright: October 30, 2009
Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 47 Issue 12

Abstract

Background: The blood-brain barrier is compromised in patients with stroke. The release of neuro-biochemical protein markers, such as neuron specific enolase (NSE) into the circulation may allow the pathophysiology and prognosis of patients with cerebrovascular diseases to be evaluated further. The present study was designed to measure the marker of neuronal damage, NSE, in saliva and serum of patients with acute ischemic stroke and patients with stroke related diseases as a diagnostic and/or monitoring tool for early prediction of ischemic stroke.

Methods: Salivary and serum NSE concentrations were measured in 150 individuals. Fifty were patients recently diagnosed as having ischemic stroke, 75 were gender and age-matched risk-group patients (patients with hypertension, type 2 diabetes and ischemic heart disease). Another 25 were gender and age-matched healthy controls.

Results: Salivary and serum NSE concentrations were significantly higher than that of healthy controls. The cut-off threshold for salivary NSE of 3.7 μg/L was optimum, showing 80% accuracy for differentiation of ischemic stroke from normal individuals.

Conclusions: Salivary NSE (alone or in combination with serum) can be used as a valuable diagnostic and possibly prognostic tool for measurement of neuronal damage in patients with stroke and stroke-related diseases.

Clin Chem Lab Med 2009;47:1519–24.

Keywords: cerebrovascular accident; neuron specific enolase; neuronal damage marker; saliva; stroke
Corresponding author: Natheer H. Al-Rawi, Assistant Professor, College of Dentistry, University of Sharjah, Sharjah, UAE
Received: 2009-5-14
Accepted: 2009-7-30
Published Online: 2009-10-30
Published in Print: 2009-12-01

©2009 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2009.345
Keywords for this article
cerebrovascular accident; neuron specific enolase; neuronal damage marker; saliva; stroke

Articles in the same Issue

  1. Review
  2. Multiple gene interaction and modulation of hemostatic balance
  3. Minireview
  4. Appropriate utilization of clinical laboratory tests
  5. Genetics and Molecular Diagnostics
  6. Quantitation of RNA decay in dried blood spots during 20 years of storage
  7. ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study
  8. Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
  9. Haplotype-based association of regulator of G-protein signaling 5 gene polymorphisms with essential hypertension and metabolic parameters in Chinese
  10. A new automated human leukocyte antigen genotyping strategy to identify DR-DQ risk alleles for celiac disease and type 1 diabetes mellitus
  11. General Clinical Chemistry and Laboratory Medicine
  12. Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults
  13. Screening for M-proteinemia: serum protein electrophoresis and free light chains compared
  14. Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke
  15. Salivary neuron specific enolase: an indicator for neuronal damage in patients with ischemic stroke and stroke-prone patients
  16. Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis
  17. Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children
  18. Nucleated red blood cells and soluble transferrin receptor in thalassemia syndromes: relationship with global and ineffective erythropoiesis
  19. Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever
  20. Preanalytical mistakes in samples from primary care patients
  21. Should kidney tubular markers be adjusted for urine creatinine? The example of urinary cystatin C
  22. Validation and Outcome Studies
  23. Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP)
  24. Development and validation of a liquid chromatography-tandem mass spectrometry assay for serum 25-hydroxyvitamin D2/D3 using a turbulent flow online extraction technology
  25. Letters to the Editor
  26. Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population
  27. Falsely elevated troponin I attributed to collection tubes using the Vitros ECiQ system
  28. Processing effects and storage conditions on A Disintegrin And Metalloprotease (ADAM12s), a maternal serum marker for adverse pregnancy outcome
  29. Serum γ-glutamyltransferase: linking together environmental pollution, redox equilibria and progression of atherosclerosis?
  30. The impact factor for evaluating scientists: the good, the bad and the ugly
  31. Acknowledgement
  32. Acknowledgement
  33. Contents
  34. Contents, Volume 47, 2009
  35. Author Index
  36. Author Index
  37. Subject Index
  38. Subject Index
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