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Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever
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Yasemin Gulcan Kurt
Published/Copyright:
December 1, 2009
Abstract
Background: Crimean-Congo hemorrhagic fever (CCHF) is a public health problem in many countries. Chitotriosidase (ChT) is an enzyme secreted by activated macrophages that catalyzes the hydrolysis of chitin and chitin-like substrates. The goal of this study was to assess the relationship between serum ChT activity and mortality.
Methods: ChT activities on the first day of hospitalization were analyzed in serum from 46 patients with CCHF and 36 healthy controls. Serum ChT activities and other clinical and laboratory parameters for patients with non-fatal and fatal CCHF were compared.
Results: The median ChT activity was increased in all patients with CCHF [189.9 (134.8–246.6) nmol/mL/h]. The median ChT activity in the non-fatal CCHF group [220.2 (180.6–290.1) nmol/mL/h] was higher compared with the fatal CCHF group [29.2 (16.5–45.7) nmol/mL/h] (p<0.001). In univariate analysis, platelet count, lactate dehydrogenase (LDH), and activated partial thromboplastin time were associated with mortality.
Conclusions: This is the first study investigating the association of serum ChT enzyme activity with mortality from CCHF. This study suggested that relatively low ChT enzyme activities may be a prognostic marker in patients with CCHF.
Clin Chem Lab Med 2009;47:1543–7.
Received: 2009-3-25
Accepted: 2009-9-8
Published Online: 2009-12-01
Published in Print: 2009-12-01
©2009 by Walter de Gruyter Berlin New York
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Keywords for this article
chitotriosidase enzyme activity;
Crimean-Congo hemorrhagic fever;
mortality
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- Multiple gene interaction and modulation of hemostatic balance
- Minireview
- Appropriate utilization of clinical laboratory tests
- Genetics and Molecular Diagnostics
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- Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
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