Total Iron Binding Capacity and Transferrin Concentration in the Assessment of Iron Status
-
Ishmael Kasvosve
Abstract
Transferrin concentration and total iron binding capacity (TIBC) are currently used to assess iron status. Although correlation between TIBC and transferrin is generally considered as good, conversion factors between the two analytes found in literature show large differences.
Although the price per test is lower for TIBC, there are a number of analytical advantages of serum transferrin. Due to binding of iron to other plasma proteins (mainly albumin), TIBC methods generally overestimate the iron binding capacity of transferrin. Moreover, no generic reference values are available for TIBC. In contrast to TIBC, internationally accepted interim reference ranges are available for serum transferrin. The introduction of the international CRM 470 protein standard material has lead to a significant reduction in interlaboratory variation for transferring measurements. In view of these observations, determination of transferrin concentration, rather than TIBC, is recommended. However, in non-European populations characterized by a marked genetic variation in transferrin (TF BC and TF CD variants), in certain cases, immunochemical determination of transferrin may lead to errors. In these populations, TIBC measurements may be preferred.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
Artikel in diesem Heft
- The 9th Asian Pacific Congress of Clinical Biochemistry
- Circulating DNA in Plasma and Serum: Biology, Preanalytical Issues and Diagnostic Applications
- Role of Steroid Hormones and Growth Factors in Breast Cancer
- Gene Polymorphism and Coronary Risk Factors in Indian Population
- Clinical Utility of Free Drug Monitoring
- Telomerase – a Potential Molecular Marker of Lung and Cervical Cancer
- Association of Polymorphisms in the Collagen Region of Human SP-A1 and SP-A2 Genes with Pulmonary Tuberculosis in Indian Population
- Effect of Hemodialysis on the Oxidative Stress and Antioxidants
- Total Iron Binding Capacity and Transferrin Concentration in the Assessment of Iron Status
- Increased Levels of Osteoprotegerin in Hemodialysis Patients
- Levels of Testosterone, Allopregnanolone and Homocysteine in Severe Hypothyroidism
- The Levels of Serum Vitamin C, Malonyldialdehyde and Erythrocyte Reduced Glutathione in Chronic Obstructive Pulmonary Disease and in Healthy Smokers
- Highly Specific, Simple and Rapid Method for the Determination of Malondialdehyde in Blood Using High-Performance Liquid Chromatography
- Precision and Accuracy of a HPLC Method for Measurement of Fecal Porphyrin Concentrations
- Continuous Age-Dependent Reference Ranges for Thyroid Hormones in Neonates, Infants, Children and Adolescents Established Using the ADVIA(r) Centaur(tm) Analyzer
- Diagnostic Value of Various Urine Tests in the Jordanian Population with Urinary Tract Infection
- Performance Evaluation of the Precision™ PCx™ Point-of-Care Blood Glucose Analyzer Using Discriminant Ratio Methodology
- Clinical Evaluation of a New Automated Anti-dsDNA Fluorescent Immunoassay
- Upper Reference Limits for Urinary Catecholamines, Metanephrines and 3-Methoxy-4-Hydroxymandelic Acid in Hypertensive Patients
- Growth Hormone Immunoassays: Proposal to Reduce Interlaboratory Variability
- Poetry, Images and Visions: William Blake
- Meetings and Awards
Artikel in diesem Heft
- The 9th Asian Pacific Congress of Clinical Biochemistry
- Circulating DNA in Plasma and Serum: Biology, Preanalytical Issues and Diagnostic Applications
- Role of Steroid Hormones and Growth Factors in Breast Cancer
- Gene Polymorphism and Coronary Risk Factors in Indian Population
- Clinical Utility of Free Drug Monitoring
- Telomerase – a Potential Molecular Marker of Lung and Cervical Cancer
- Association of Polymorphisms in the Collagen Region of Human SP-A1 and SP-A2 Genes with Pulmonary Tuberculosis in Indian Population
- Effect of Hemodialysis on the Oxidative Stress and Antioxidants
- Total Iron Binding Capacity and Transferrin Concentration in the Assessment of Iron Status
- Increased Levels of Osteoprotegerin in Hemodialysis Patients
- Levels of Testosterone, Allopregnanolone and Homocysteine in Severe Hypothyroidism
- The Levels of Serum Vitamin C, Malonyldialdehyde and Erythrocyte Reduced Glutathione in Chronic Obstructive Pulmonary Disease and in Healthy Smokers
- Highly Specific, Simple and Rapid Method for the Determination of Malondialdehyde in Blood Using High-Performance Liquid Chromatography
- Precision and Accuracy of a HPLC Method for Measurement of Fecal Porphyrin Concentrations
- Continuous Age-Dependent Reference Ranges for Thyroid Hormones in Neonates, Infants, Children and Adolescents Established Using the ADVIA(r) Centaur(tm) Analyzer
- Diagnostic Value of Various Urine Tests in the Jordanian Population with Urinary Tract Infection
- Performance Evaluation of the Precision™ PCx™ Point-of-Care Blood Glucose Analyzer Using Discriminant Ratio Methodology
- Clinical Evaluation of a New Automated Anti-dsDNA Fluorescent Immunoassay
- Upper Reference Limits for Urinary Catecholamines, Metanephrines and 3-Methoxy-4-Hydroxymandelic Acid in Hypertensive Patients
- Growth Hormone Immunoassays: Proposal to Reduce Interlaboratory Variability
- Poetry, Images and Visions: William Blake
- Meetings and Awards
