Increased Levels of Osteoprotegerin in Hemodialysis Patients
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Ivica Avbersek-Luznik
Abstract
Recently identified soluble circulating osteoprotegerin (OPG), a member of tumor necrosis factor receptor family, is the osteoclastogenesis inhibitory factor (OCIF). It acts as a “decoy” receptor for receptor activator of NF-κB ligand (RANKL) and antagonises RANKL/RANK activity. This way OPG exerts the protective effect on bone, which is also important in hyperparathyroidism. The studies measuring OPG levels in secondary hyperparathyroidism have shown contradictory results and inconsistent conclusions.
The aim of our work was to evaluate OPG levels in hemodialysis patients and their correlation with the intensity of bone turnover, bone formation and bone resorption. Serum OPG levels, bone alkaline phosphatase activity (bALP) and β-CrossLaps (CTx) were measured in a control group (n = 20, age 30±6.7 years) and in two groups of dialysis patients: the first group with serum intact parathyroid hormone (iPTH) concentration below 200 pg/ml (n = 28, age 62.6±14.8 years) and the second group with iPTH concentration above 200 pg/ml (n = 16, age 63.7±14.8 years). Compared to controls, serum OPG levels were 6.4-fold higher in dialysis patients. OPG levels in patients with high PTH were approximately 1.2-fold higher than in the low-PTH group. OPG correlated weakly with bALP (r = 0.277, p = 0.153), as well as with CTx (r = 0.018, p = 0.929) in the low-PTH group, and there was an insignificant negative correlation in the high-PTH group (r = −0.145, p = 0.593 and r = −0.219, p = 0.416, respectively). In conclusion, 6.4-fold increase in OPG might protect bone against intensive bone loss in hemodialysis patients, but this increase is probably not mediated by the increased bone formation; rather, it seems to be the consequence of the imbalance of bone kinetics in renal disease. The precise role of OPG in the pathogenesis of renal osteodystrophy remains unknown and establishing it requires further studies.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- The 9th Asian Pacific Congress of Clinical Biochemistry
- Circulating DNA in Plasma and Serum: Biology, Preanalytical Issues and Diagnostic Applications
- Role of Steroid Hormones and Growth Factors in Breast Cancer
- Gene Polymorphism and Coronary Risk Factors in Indian Population
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- Telomerase – a Potential Molecular Marker of Lung and Cervical Cancer
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- Effect of Hemodialysis on the Oxidative Stress and Antioxidants
- Total Iron Binding Capacity and Transferrin Concentration in the Assessment of Iron Status
- Increased Levels of Osteoprotegerin in Hemodialysis Patients
- Levels of Testosterone, Allopregnanolone and Homocysteine in Severe Hypothyroidism
- The Levels of Serum Vitamin C, Malonyldialdehyde and Erythrocyte Reduced Glutathione in Chronic Obstructive Pulmonary Disease and in Healthy Smokers
- Highly Specific, Simple and Rapid Method for the Determination of Malondialdehyde in Blood Using High-Performance Liquid Chromatography
- Precision and Accuracy of a HPLC Method for Measurement of Fecal Porphyrin Concentrations
- Continuous Age-Dependent Reference Ranges for Thyroid Hormones in Neonates, Infants, Children and Adolescents Established Using the ADVIA(r) Centaur(tm) Analyzer
- Diagnostic Value of Various Urine Tests in the Jordanian Population with Urinary Tract Infection
- Performance Evaluation of the Precision™ PCx™ Point-of-Care Blood Glucose Analyzer Using Discriminant Ratio Methodology
- Clinical Evaluation of a New Automated Anti-dsDNA Fluorescent Immunoassay
- Upper Reference Limits for Urinary Catecholamines, Metanephrines and 3-Methoxy-4-Hydroxymandelic Acid in Hypertensive Patients
- Growth Hormone Immunoassays: Proposal to Reduce Interlaboratory Variability
- Poetry, Images and Visions: William Blake
- Meetings and Awards
