Levels of Testosterone, Allopregnanolone and Homocysteine in Severe Hypothyroidism
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Marie Bičíková
Abstract
Hypothyroidism is very often associated with cardiovascular diseases and neurological complications. Recently, homocysteine has been studied as an independent risk factor for atherosclerosis which negatively affects vascular endothelial cells. Because homocysteine metabolism is related to thyroid and steroid hormones, we studied these relationships in severe hypothyroidism and in euthyroid state. Homocysteine, testosterone and allopregnanolone concentrations were measured in the fasting plasma from 16 women who underwent total thyroidectomy, and who were either hypothyroid or euthyroid. Although all women used oral contraceptives, they were not protected against hyperhomocysteinemia during hypothyroid state. With the normalization of thyroid hormone concentrations homocysteine levels decreased to normal levels. There was a positive correlation between testosterone and homocysteine in the euthyroid state which suggests that not only estrogens but also androgen state should be considered in future studies on homocysteine.
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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- Poetry, Images and Visions: William Blake
- Meetings and Awards
Articles in the same Issue
- The 9th Asian Pacific Congress of Clinical Biochemistry
- Circulating DNA in Plasma and Serum: Biology, Preanalytical Issues and Diagnostic Applications
- Role of Steroid Hormones and Growth Factors in Breast Cancer
- Gene Polymorphism and Coronary Risk Factors in Indian Population
- Clinical Utility of Free Drug Monitoring
- Telomerase – a Potential Molecular Marker of Lung and Cervical Cancer
- Association of Polymorphisms in the Collagen Region of Human SP-A1 and SP-A2 Genes with Pulmonary Tuberculosis in Indian Population
- Effect of Hemodialysis on the Oxidative Stress and Antioxidants
- Total Iron Binding Capacity and Transferrin Concentration in the Assessment of Iron Status
- Increased Levels of Osteoprotegerin in Hemodialysis Patients
- Levels of Testosterone, Allopregnanolone and Homocysteine in Severe Hypothyroidism
- The Levels of Serum Vitamin C, Malonyldialdehyde and Erythrocyte Reduced Glutathione in Chronic Obstructive Pulmonary Disease and in Healthy Smokers
- Highly Specific, Simple and Rapid Method for the Determination of Malondialdehyde in Blood Using High-Performance Liquid Chromatography
- Precision and Accuracy of a HPLC Method for Measurement of Fecal Porphyrin Concentrations
- Continuous Age-Dependent Reference Ranges for Thyroid Hormones in Neonates, Infants, Children and Adolescents Established Using the ADVIA(r) Centaur(tm) Analyzer
- Diagnostic Value of Various Urine Tests in the Jordanian Population with Urinary Tract Infection
- Performance Evaluation of the Precision™ PCx™ Point-of-Care Blood Glucose Analyzer Using Discriminant Ratio Methodology
- Clinical Evaluation of a New Automated Anti-dsDNA Fluorescent Immunoassay
- Upper Reference Limits for Urinary Catecholamines, Metanephrines and 3-Methoxy-4-Hydroxymandelic Acid in Hypertensive Patients
- Growth Hormone Immunoassays: Proposal to Reduce Interlaboratory Variability
- Poetry, Images and Visions: William Blake
- Meetings and Awards
