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Recent developments in the synthesis and anti-cancer activity of acridine and xanthine-based molecules

  • Sasadhar Majhi ORCID logo EMAIL logo
Published/Copyright: January 5, 2022
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Physical Sciences Reviews
From the journal Physical Sciences Reviews Volume 8 Issue 9

Abstract

Cancer is the uncontrolled growth and development of abnormal cells which is a major cause of death in both advanced and emerging countries. Although currently chemotherapy is most broadly used among an extensive range of anti-cancer therapies, it includes many demerits, such as highly toxic, side-effects, expensive and partial lack of targeting specificity. So the design and synthesis of new molecules that perform specifically on target proteins in tumor cells is a focus of contemporary research. So many researchers aim for new drugs that will be more efficient, more selective, and less toxic. Because of the interesting structures and significant biological profile, naturally occurring acridines and xanthines as well as their analogues have attracted considerable interest in researchers and technologists. Natural and synthetic acridine derivatives form a significant category of heterocycles having nitrogen that is of considerable interest for organic chemists and biological communities due to their attractive anti-cancer activity. Another important class of therapeutic agents with diverse biological properties including cytotoxic effects is xanthine derivatives which are collectively called xanthines (a group of alkaloids). Among many significant molecules based on the structure of the purine, there is a group of natural xanthines, involving theobromine, caffeine, and theophylline and analogues of xanthine display anti-cancer activity. Hence the present chapter wishes to concentrate the attention on the synthesis and anti-cancer activity of acridine and xanthine-based compounds brilliantly.

Keywords: acridine and xanthine-based compounds; anti-cancer activity; drug discovery; synthetic analogues
Corresponding author: Sasadhar Majhi, Department of Chemistry (UG & PG Dept.), Triveni Devi Bhalotia College, Kazi Nazrul University, Raniganj, West Bengal 713347, India, E-mail:

Acknowledgments

The author is thankful to his heavenly father Tarani Majhi; he also gratefully acknowledges the moral support from his mother Sadeswari Majhi. S Majhi is also grateful to the respected principal A K Dey of the Triveni Devi Bhalotia College for his inspiration throughout.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Published Online: 2022-01-05

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https://doi.org/10.1515/psr-2021-0216
Keywords for this article
acridine and xanthine-based compounds; anti-cancer activity; drug discovery; synthetic analogues

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  12. Chemical computational approaches for optimization of effective surfactants in enhanced oil recovery
  13. Social media and learning in an era of coronavirus among chemistry students in tertiary institutions in Rivers State
  14. Techniques for the detection and quantification of emerging contaminants
  15. Occurrence, fate, and toxicity of emerging contaminants in a diverse ecosystem
  16. Updates on the versatile quinoline heterocycles as anticancer agents
  17. Trends in microbial degradation and bioremediation of emerging contaminants
  18. Power to the city: Assessing the rooftop solar photovoltaic potential in multiple cities of Ecuador
  19. Phytoremediation as an effective tool to handle emerging contaminants
  20. Recent advances and prospects for industrial waste management and product recovery for environmental appliances: a review
  21. Integrating multi-objective superstructure optimization and multi-criteria assessment: a novel methodology for sustainable process design
  22. A conversation on the quartic equation of the secular determinant of methylenecyclopropene
  23. Recent developments in the synthesis and anti-cancer activity of acridine and xanthine-based molecules
  24. An overview of in silico methods used in the design of VEGFR-2 inhibitors as anticancer agents
  25. Fragment based drug design
  26. Advances in heterocycles as DNA intercalating cancer drugs
  27. Systems biology–the transformative approach to integrate sciences across disciplines
  28. Pharmaceutical interest of in-silico approaches
  29. Membrane technologies for sports supplementation
  30. Fused pyrrolo-pyridines and pyrrolo-(iso)quinoline as anticancer agents
  31. Membrane applications in the food industry
  32. Membrane techniques in the production of beverages
  33. Statistical methods for in silico tools used for risk assessment and toxicology
  34. Dicarbonyl compounds in the synthesis of heterocycles under green conditions
  35. Green synthesis of triazolo-nucleoside conjugates via azide–alkyne C–N bond formation
  36. Anaerobic digestion fundamentals, challenges, and technological advances
  37. Survival is the driver for adaptation: safety engineering changed the future, security engineering prevented disasters and transition engineering navigates the pathway to the climate-safe future
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