Startseite Three years of liraglutide treatment offers continuously optimal glycemic control in a pediatric patient with maturity-onset diabetes of the young type 3
Artikel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

Three years of liraglutide treatment offers continuously optimal glycemic control in a pediatric patient with maturity-onset diabetes of the young type 3

  • Tatsuhiko Urakami EMAIL logo , Masako Habu , Misako Okuno , Junichi Suzuki , Shori Takahashi und Tohru Yorifuji
Veröffentlicht/Copyright: 18. Oktober 2014
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 28 Heft 3-4

Abstract

Sulfonylureas (SUs) are recommended as the first-line pharmacological treatment in patients with uncontrolled maturity-onset diabetes of the young type 3 (MODY3). In contrast, glucagon-like peptide-1 (GLP-1) receptor agonists have the advantages of a low risk of hypoglycemia and maintained β-cell function. We report a pediatric patient with MODY3 treated with a GLP-1 receptor agonist, liraglutide. A 12-year-old Japanese girl with MODY3 had been treated with insulin for 6 months since the time of diagnosis. After genetic analysis, we switched her treatment from insulin to liraglutide. After switching to liraglutide, the patient maintained optimal glycemic control with hemoglobin A1c levels of 6.8%–7.5% and had postprandial C-peptide levels >3.0 ng/mL during a 3-year treatment period. No adverse events associated with liraglutide were observed. GLP-1 receptor agonists are the potential medications for patients with MODY3 who maintain residual insulin secretion.

Keywords: endogenous insulin secretion; GLP-1 receptor agonist; glycemic control; MODY3; pediatric patient
Corresponding author: Tatsuhiko Urakami, MD, Department of Pediatrics, Nihon University School of Medicine, 1-8-13 Kandasurugadai, Chiyoda-ku, 101-8309 Tokyo, Japan, Phone: +81 332931711, Fax: +81 332931798, E-mail:

Conflict of interest statement

Disclosure: None of the authors of the article has any conflicts of interest associated with this study.

References

1. Fajans SS, Conn JW. Tolbutamide-induced improvement in carbohydrate tolerance of young people with mild diabetes mellitus. Diabetes 1960;9:83–8.10.2337/diab.9.2.83Suche in Google Scholar

2. Tattersall RB. Mild familiar diabetes with dominant inheritance. Q J Med 1974;43:339–57.Suche in Google Scholar

3. McDonald TJ, Colclough K, Brown R, Shields B, Shepherd M, et al. Islet autoantibodies can discriminate maturity-onset diabetes of the young (MODY) from type 1 diabetes. Diabet Med 2011;28:1028–33.10.1111/j.1464-5491.2011.03287.xSuche in Google Scholar

4. Kavvoura FK, Owen KR. Maturity-onset diabetes of the young: clinical characteristics, diagnosis and management. Pediatr Endocrinol Rev 2013;10:234–42.Suche in Google Scholar

5. Frayling TM, Bulamn MP, Ellard S, Appletion M, Dronsfield MJ, et al. Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the UK. Diabetes 1997;46:720–5.10.2337/diab.46.4.720Suche in Google Scholar

6. Hattersley A, Bruining J, Shield J, Njolstad P, Donaghue KC. ISPAD Clinical Consensus Practice Guidelines 2006-2007. The diagnosis and management of monogenic diabetes in children and adolescents. Pediatr Diabetes 2006;7:352–60.10.1111/j.1399-5448.2006.00217.xSuche in Google Scholar

7. Pearson ER, Starkey BJ, Powell RJ, Gribble FM, Clark PM, et al. Genetic cause of hyperglycemia and response to treatment in diabetes. Lancet 2003;362:1275–81.10.1016/S0140-6736(03)14571-0Suche in Google Scholar

8. Shepherd M, Shields B, Ellard S, Rubio-Cabezas O, Hattersley AT. A genetic diagnosis of HNF1A diabetes alters treatment and improves glycemic control in the majority of insulin-treated patients. Diabet Med 2009;26:437–41.10.1111/j.1464-5491.2009.02690.xSuche in Google Scholar PubMed

9. Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for Study of Diabetes. Diabetes Care 2009;32:193–203.10.2337/dc08-9025Suche in Google Scholar PubMed PubMed Central

10. Madsbad S. Exenatide and liraglutide: different approaches to develop GLP-1 receptor agonists (incretin mimetics)-preclinical and clinical results: Best Pract Res Clin Endocrinol Metab 2009;23:463–77.10.1016/j.beem.2009.03.008Suche in Google Scholar PubMed

11. Russell-Jones D. The safety of GLP-1 receptor agonists in the treatment of type 2 diabetes. Int J Clin Pract 2010;64:1402–14.10.1111/j.1742-1241.2010.02465.xSuche in Google Scholar PubMed

12. Degn KB, Juhl CB, Sturis J, Jakobsen G, Brock B, et al. One week’s treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes. Diabetes 2004;53:1187–94.10.2337/diabetes.53.5.1187Suche in Google Scholar PubMed

13. Kothare PA, Seger ME, Northrup J, Mace K, Mitchell MI, et al. Effect of exenatide on the pharmacokinetics of a combination oral contraceptive in healthy women: an open-label, randomized, crossover trial. J Clin Pharmacol 2008;48:1389–99.10.1177/0091270008323750Suche in Google Scholar

14. Bregenholt S, Møldrup A, Blume N. The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro. Biochem Biophys Res Commun 2005;330:577–84.10.1016/j.bbrc.2005.03.013Suche in Google Scholar

15. Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006;368:1696–705.10.1016/S0140-6736(06)69705-5Suche in Google Scholar

16. Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, et al. Management of hyperglycemia in type 2 diabetes: A patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012;35:1364–79.10.2337/dc12-0413Suche in Google Scholar PubMed PubMed Central

17. Rosenbloom AL, Silverstein JH, Amemiya S, Zeltler P, Klingensmith GJ. ISPAD Clinical Practice Consensus Guidelines 2009 Compendium. Type 2 diabetes in children and adolescents. Pediatr Diabetes 2008;9:512–26.10.1111/j.1399-5448.2008.00429.xSuche in Google Scholar PubMed

18. Urakami T, Morimoto S, Nitadori Y, Harada K, Owada M, et al. Urine glucose screening program at schools in Japan to detect children with diabetes and its outcome-incidence and clinical characteristics of childhood type 2 diabetes in Japan. Pediatr Res 2007;61:141–5.10.1203/pdr.0b013e31802d8a69Suche in Google Scholar PubMed

19. Kashiwagi A, Kasuga M, Araki E, Oka Y, Hanafusa T, et al. International clinical harmonization of glycated hemoglobin in Japan: From Japan Diabetes Society to National Glycohemoglobin Standardization Program values. J Diabetes Invest 2012;3:39–40.10.1111/j.2040-1124.2012.00207.xSuche in Google Scholar PubMed PubMed Central

20. Yorifuji T, Fujimaru R, Hosokawa Y, Tamagawa N, Shiozaki M, et al. Comprehensive molecular analysis of Japanese patients with pediatric-onset MODY-type diabetes mellitus. Pediatr Diabetes 2012;13:26–32.10.1111/j.1399-5448.2011.00827.xSuche in Google Scholar PubMed

21. Winter WE. Molecular and biochemical analysis of the MODY syndrome. Pediatr Diabetes 2000;1:88–117.10.1034/j.1399-5448.2000.010206.xSuche in Google Scholar PubMed

22. Byrne MM, Sturis J, Menzel S, Yamagata K, Fajans SS, et al. Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12. Diabetes 1996;45:1503–10.10.2337/diab.45.11.1503Suche in Google Scholar PubMed

23. Lehto M, Tuomi T, Mahtani MM, Widén E, Forsblom C, et al. Characterization of the MODY phenotype. J Clin Invest 1997;99:582–91.10.1172/JCI119199Suche in Google Scholar

24. Shehadeh N, Zuckerman-Levin N, Daich E. Can GLP-1 preparations be used in children and adolescents with diabetes mellitus? Pediatric Endocr Rev 2014;11:324–7.Suche in Google Scholar

25. Bergenstal RM, Wysham C, MacConell L, Malloy J, Walsh B, et al. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjust to metformin for treatment of type 2 diabetes (DURATION-2): a randomized trial. Lancet 2010;376:431–9.10.1016/S0140-6736(10)60590-9Suche in Google Scholar

26. Pratley RE, Nauck M, Bailey T, Montanya E, Cuddihy R, et al. Liraglitide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycemic control with metformin: a 26-week, randomized, parallel-group, open-label trial. Lancet 2010;375:1447–56.10.1016/S0140-6736(10)60307-8Suche in Google Scholar

27. Pratley RE, Nauck M, Bailey T, Montanya E, Cuddihy R, et al. One year of liraglutide treatment offers sustained and more effective glycemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomized, parallel-group, open-label trial. Int J Clin Pract 2011;65:397–407.10.1111/j.1742-1241.2011.02656.xSuche in Google Scholar PubMed PubMed Central

28. Pi-Sunyer FX, Schweizer A, Mills D, Dejager S. Efficacy and tolerability of vildagliptin monotherapy in drug-naive patients with type 2 diabetes. Diabetes Res Clin Pract 2007;76:132–8.10.1016/j.diabres.2006.12.009Suche in Google Scholar PubMed

29. Conarello SL, Li Z, Ronan J, Roy RS, Zhu L, et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. Proc Natl Acad Sci U S A 2003;100:6825–30.10.1073/pnas.0631828100Suche in Google Scholar PubMed PubMed Central

30. Dukes ID, Sreenan S, Roe MW, Levisetti M, Zhou YP, et al. Defective pancreatic beta cell glycolytic signaling in hepatocyte nuclear factor 1a deficient mice. J Biol Chem 1998;273: 24457–64.10.1074/jbc.273.38.24457Suche in Google Scholar PubMed

Received: 2014-5-20
Accepted: 2014-9-5
Published Online: 2014-10-18
Published in Print: 2015-3-1

©2015 by De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. Highlight: Diabetes
  3. Diabetes mellitus in children and adolescents – a global epidemic which has become neglected
  4. Maturity-onset diabetes of the young (MODY): an update
  5. Relationship of plasma level of chemerin and vaspin to early atherosclerotic changes and cardiac autonomic neuropathy in adolescent type 1 diabetic patients
  6. How does autoimmune thyroiditis in children with type 1 diabetes mellitus influence glycemic control, lipid profile and thyroid volume?
  7. Profile of mood states in adult type 1 diabetes mellitus men and women with disease onset in childhood and in adulthood
  8. Evaluation of fetuin-A and carotid intima-media thickness in adolescent type 1 diabetic patients
  9. An increasing incidence of type 1 diabetes mellitus in Romanian children aged 0 to 17 years
  10. Resistin and right ventricular function in children with recently diagnosed type-1 diabetes mellitus: a case control study
  11. Assessment of human cartilage glycoprotein 39 (YKL-40), preptin, and nitric oxide in adolescent patients with type 1 diabetes and its relation to cardiorenal affection
  12. The effect of a home-based strength training program on type 2 diabetes risk in obese Latino boys
  13. From cerebral salt wasting to diabetes insipidus with adipsia: case report of a child with craniopharyngioma
  14. Three years of liraglutide treatment offers continuously optimal glycemic control in a pediatric patient with maturity-onset diabetes of the young type 3
  15. Diabetic euglycemic ketoacidosis in newly diagnosed type 1 diabetes mellitus during Ramadan fasting
  16. Transient neonatal hyperinsulinism with adaptation disorders: a report of three cases
  17. Acute mononeuropathy in a child with newly diagnosed type 1 diabetes mellitus
  18. Alternating hypoglycemia and hyperglycemia in a toddler with a homozygous p.R1419H ABCC8 mutation: an unusual clinical picture
  19. Cognitive functioning, metabolic control, and treatment type in youth with type 1 diabetes
  20. Images in pediatric endocrinology
  21. Benefit of testosterone in pediatric genital trauma
  22. Original articles
  23. Attenuated salivary cortisol response after exercise test in children with asthma
  24. Reliability of pubertal maturation self-assessment in a school-based survey
  25. Detection of inborn errors of metabolism using GC-MS: over 3 years of experience in southern China
  26. Assessing biological maturity: chronological age and the pubertal development scale predict free testosterone in adolescent males
  27. Evaluation of puberty by verifying spontaneous and stimulated gonadotropin values in girls
  28. Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children
  29. Caries in adolescents in relation to their skeletal status
  30. Endothelial and metabolic disorders in adolescence: low birth weight is not an isolated risk factor
  31. Comparison of cortisol samples in the first two weeks of life in preterm infants
  32. Mutations in BTD gene causing biotinidase deficiency: a regional report
  33. Patient reports
  34. Late-onset hypercalcemia in Williams-Beuren syndrome: importance of early and frequent screening and intervention
  35. Hepatoblastoma presenting as precocious puberty: a case report
  36. Three cases of Wolfram syndrome with different clinical aspects
  37. L-asparaginase induced hypoglycemia in a case of acute lymphoblastic leukemia: a patient report
  38. Pyogenic granuloma, an unusual presentation of peripubertal vaginal bleeding. Case report and review of the literature
  39. Octreotide-associated cholestasis and hepatitis in an infant with congenital hyperinsulinism
  40. Two novel mutations in the homogentisate-1,2-dioxygenase gene identified in Chinese Han Child with Alkaptonuria
  41. Pituitary abscess in an adolescent girl: a case report and review of the literature
  42. Neonatal thyrotoxicosis with severe supraventricular tachycardia: case report and review of the literature
  43. Consumptive hypothyroidism associated with parotid infantile hemangioma
  44. Novel mutations in the SLC25A13 gene in a patient with NICCD and severe manifestations
  45. Short communications
  46. Tetrahydrobiopterin deficiency among Serbian patients presenting with hyperphenylalaninemia
https://doi.org/10.1515/jpem-2014-0211
Schlagwörter für diesen Artikel
endogenous insulin secretion; GLP-1 receptor agonist; glycemic control; MODY3; pediatric patient

Artikel in diesem Heft

  1. Frontmatter
  2. Highlight: Diabetes
  3. Diabetes mellitus in children and adolescents – a global epidemic which has become neglected
  4. Maturity-onset diabetes of the young (MODY): an update
  5. Relationship of plasma level of chemerin and vaspin to early atherosclerotic changes and cardiac autonomic neuropathy in adolescent type 1 diabetic patients
  6. How does autoimmune thyroiditis in children with type 1 diabetes mellitus influence glycemic control, lipid profile and thyroid volume?
  7. Profile of mood states in adult type 1 diabetes mellitus men and women with disease onset in childhood and in adulthood
  8. Evaluation of fetuin-A and carotid intima-media thickness in adolescent type 1 diabetic patients
  9. An increasing incidence of type 1 diabetes mellitus in Romanian children aged 0 to 17 years
  10. Resistin and right ventricular function in children with recently diagnosed type-1 diabetes mellitus: a case control study
  11. Assessment of human cartilage glycoprotein 39 (YKL-40), preptin, and nitric oxide in adolescent patients with type 1 diabetes and its relation to cardiorenal affection
  12. The effect of a home-based strength training program on type 2 diabetes risk in obese Latino boys
  13. From cerebral salt wasting to diabetes insipidus with adipsia: case report of a child with craniopharyngioma
  14. Three years of liraglutide treatment offers continuously optimal glycemic control in a pediatric patient with maturity-onset diabetes of the young type 3
  15. Diabetic euglycemic ketoacidosis in newly diagnosed type 1 diabetes mellitus during Ramadan fasting
  16. Transient neonatal hyperinsulinism with adaptation disorders: a report of three cases
  17. Acute mononeuropathy in a child with newly diagnosed type 1 diabetes mellitus
  18. Alternating hypoglycemia and hyperglycemia in a toddler with a homozygous p.R1419H ABCC8 mutation: an unusual clinical picture
  19. Cognitive functioning, metabolic control, and treatment type in youth with type 1 diabetes
  20. Images in pediatric endocrinology
  21. Benefit of testosterone in pediatric genital trauma
  22. Original articles
  23. Attenuated salivary cortisol response after exercise test in children with asthma
  24. Reliability of pubertal maturation self-assessment in a school-based survey
  25. Detection of inborn errors of metabolism using GC-MS: over 3 years of experience in southern China
  26. Assessing biological maturity: chronological age and the pubertal development scale predict free testosterone in adolescent males
  27. Evaluation of puberty by verifying spontaneous and stimulated gonadotropin values in girls
  28. Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children
  29. Caries in adolescents in relation to their skeletal status
  30. Endothelial and metabolic disorders in adolescence: low birth weight is not an isolated risk factor
  31. Comparison of cortisol samples in the first two weeks of life in preterm infants
  32. Mutations in BTD gene causing biotinidase deficiency: a regional report
  33. Patient reports
  34. Late-onset hypercalcemia in Williams-Beuren syndrome: importance of early and frequent screening and intervention
  35. Hepatoblastoma presenting as precocious puberty: a case report
  36. Three cases of Wolfram syndrome with different clinical aspects
  37. L-asparaginase induced hypoglycemia in a case of acute lymphoblastic leukemia: a patient report
  38. Pyogenic granuloma, an unusual presentation of peripubertal vaginal bleeding. Case report and review of the literature
  39. Octreotide-associated cholestasis and hepatitis in an infant with congenital hyperinsulinism
  40. Two novel mutations in the homogentisate-1,2-dioxygenase gene identified in Chinese Han Child with Alkaptonuria
  41. Pituitary abscess in an adolescent girl: a case report and review of the literature
  42. Neonatal thyrotoxicosis with severe supraventricular tachycardia: case report and review of the literature
  43. Consumptive hypothyroidism associated with parotid infantile hemangioma
  44. Novel mutations in the SLC25A13 gene in a patient with NICCD and severe manifestations
  45. Short communications
  46. Tetrahydrobiopterin deficiency among Serbian patients presenting with hyperphenylalaninemia
Jetzt anmelden und 20% sparen
Institutioneller Zugang
Wie funktioniert Authentifizierung?
Haben Sie eine Idee, wie wir unsere Website verbessern können?
Bitte schreiben Sie uns.
© 2025 De Gruyter Brill
Heruntergeladen am 9.10.2025 von https://www.degruyterbrill.com/document/doi/10.1515/jpem-2014-0211/html
Button zum nach oben scrollen