Evaluation of puberty by verifying spontaneous and stimulated gonadotropin values in girls
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Vivian L. Chin
Abstract
Background: Changes in pharmacological agents and advancements in laboratory assays have changed the gonadotropin-releasing hormone analog stimulation test.
Objective: To determine the best predictive model for detecting puberty in girls.
Subjects: Thirty-five girls, aged 2 years 7 months to 9 years 3 months, with central precocious puberty (CPP) (n=20) or premature thelarche/premature adrenarche (n=15).
Methods: Diagnoses were based on clinical information, baseline hormones, bone age, and pelvic sonogram. Gonadotropins and E2 were analyzed using immunochemiluminometric assay. Logistic regression for CPP was performed.
Results: The best predictor of CPP is the E2-change model based on 3- to 24-h values, providing 80% sensitivity and 87% specificity. Three-hour luteinizing hormone (LH) provided 75% sensitivity and 87% specificity. Basal LH lowered sensitivity to 65% and specificity to 53%.
Conclusions: The E2-change model provided the best predictive power; however, 3-h LH was more practical and convenient when evaluating puberty in girls.
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©2015 by De Gruyter
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Articles in the same Issue
- Frontmatter
- Highlight: Diabetes
- Diabetes mellitus in children and adolescents – a global epidemic which has become neglected
- Maturity-onset diabetes of the young (MODY): an update
- Relationship of plasma level of chemerin and vaspin to early atherosclerotic changes and cardiac autonomic neuropathy in adolescent type 1 diabetic patients
- How does autoimmune thyroiditis in children with type 1 diabetes mellitus influence glycemic control, lipid profile and thyroid volume?
- Profile of mood states in adult type 1 diabetes mellitus men and women with disease onset in childhood and in adulthood
- Evaluation of fetuin-A and carotid intima-media thickness in adolescent type 1 diabetic patients
- An increasing incidence of type 1 diabetes mellitus in Romanian children aged 0 to 17 years
- Resistin and right ventricular function in children with recently diagnosed type-1 diabetes mellitus: a case control study
- Assessment of human cartilage glycoprotein 39 (YKL-40), preptin, and nitric oxide in adolescent patients with type 1 diabetes and its relation to cardiorenal affection
- The effect of a home-based strength training program on type 2 diabetes risk in obese Latino boys
- From cerebral salt wasting to diabetes insipidus with adipsia: case report of a child with craniopharyngioma
- Three years of liraglutide treatment offers continuously optimal glycemic control in a pediatric patient with maturity-onset diabetes of the young type 3
- Diabetic euglycemic ketoacidosis in newly diagnosed type 1 diabetes mellitus during Ramadan fasting
- Transient neonatal hyperinsulinism with adaptation disorders: a report of three cases
- Acute mononeuropathy in a child with newly diagnosed type 1 diabetes mellitus
- Alternating hypoglycemia and hyperglycemia in a toddler with a homozygous p.R1419H ABCC8 mutation: an unusual clinical picture
- Cognitive functioning, metabolic control, and treatment type in youth with type 1 diabetes
- Images in pediatric endocrinology
- Benefit of testosterone in pediatric genital trauma
- Original articles
- Attenuated salivary cortisol response after exercise test in children with asthma
- Reliability of pubertal maturation self-assessment in a school-based survey
- Detection of inborn errors of metabolism using GC-MS: over 3 years of experience in southern China
- Assessing biological maturity: chronological age and the pubertal development scale predict free testosterone in adolescent males
- Evaluation of puberty by verifying spontaneous and stimulated gonadotropin values in girls
- Longitudinal changes in C-reactive protein, proform of eosinophil major basic protein, and pregnancy-associated plasma protein-A during weight changes in obese children
- Caries in adolescents in relation to their skeletal status
- Endothelial and metabolic disorders in adolescence: low birth weight is not an isolated risk factor
- Comparison of cortisol samples in the first two weeks of life in preterm infants
- Mutations in BTD gene causing biotinidase deficiency: a regional report
- Patient reports
- Late-onset hypercalcemia in Williams-Beuren syndrome: importance of early and frequent screening and intervention
- Hepatoblastoma presenting as precocious puberty: a case report
- Three cases of Wolfram syndrome with different clinical aspects
- L-asparaginase induced hypoglycemia in a case of acute lymphoblastic leukemia: a patient report
- Pyogenic granuloma, an unusual presentation of peripubertal vaginal bleeding. Case report and review of the literature
- Octreotide-associated cholestasis and hepatitis in an infant with congenital hyperinsulinism
- Two novel mutations in the homogentisate-1,2-dioxygenase gene identified in Chinese Han Child with Alkaptonuria
- Pituitary abscess in an adolescent girl: a case report and review of the literature
- Neonatal thyrotoxicosis with severe supraventricular tachycardia: case report and review of the literature
- Consumptive hypothyroidism associated with parotid infantile hemangioma
- Novel mutations in the SLC25A13 gene in a patient with NICCD and severe manifestations
- Short communications
- Tetrahydrobiopterin deficiency among Serbian patients presenting with hyperphenylalaninemia
