Consumptive hypothyroidism associated with parotid infantile hemangioma
-
Federica De Corti
,
Carlo Crivellaro
Abstract
Consumptive hypothyroidism is a rare condition usually described in association with diffuse infantile hemangioma of the liver, over-expressing type 3 iodothyronine-deiodinase. We report a case of acquired hypothyroidism associated with a parotid hemangioma in a male child, who was initially evaluated at 48 days of age due to persistent jaundice. Replacement hormonal therapy was promptly started, but resolution of the clinical and laboratory findings of hypothyroidism was only achieved at 3 months of age, when propranolol treatment was added to the therapeutic regimen. Our review of the literature retrieved only one case of proven consumptive hypothyroidism associated with a parotid infantile hemangioma, making a real incidence an underestimate: we believe one should consider this association a real possibility.
References
1. Huang SA, Tu HM, Harney JW, Venihaki M, Butte AJ, et al. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med 2000;343:185–9.10.1056/NEJM200007203430305Search in Google Scholar PubMed
2. Jassam N, Visser TJ, Brisco T, Bathia D, McClean P, et al. Consumptive hypothyroidism: a case report and review of the literature. Ann Clin Biochem 2011;48:186–9.10.1258/acb.2010.010170Search in Google Scholar PubMed
3. Kulungowski AM, Alomari AI, Chawla A, Christison-Lagay ER, Fishman SJ. Lessons from a liver hemangioma registry: subtype classification. J Pediatr Surg 2012;47:165–70.10.1016/j.jpedsurg.2011.10.037Search in Google Scholar PubMed
4. Marsciani A, Alaggio R, Brisigotti M, Vergine G. Massive response of severe infantile hepatic emangioma to propranolol. Pediatr Blood Cancer 2010;54:176.10.1002/pbc.22262Search in Google Scholar PubMed
5. Vigone MC, Cortinovis F, Rabbiosi S, Di Frenna M, Passoni A, et al. Difficult treatment of consumptive hypothyroidism in a child with massive parotid hemangioma. J Pediatr Endocrinol Metab 2012;25:153–5.10.1515/jpem.2011.438Search in Google Scholar PubMed
6. Shehata N, Powell J, Dubois J, Hatami A, Rousseau E, et al. Late rebound of infantile hemangioma after cessation of oral propranolol. Pediatr Dermatol 2013;30:587–91.10.1111/pde.12190Search in Google Scholar PubMed
7. Menezes MD, McCarter R, Greene EA, Bauman NM. Status of propranolol for treatment of infantile hemangioma and description of a randomized clinical trial. Ann Otol Rhinol Laryngol 2011;120:686–95.10.1177/000348941112001010Search in Google Scholar PubMed
8. Greene AK, Rogers GF, Mulliken JB. Management of parotid hemangioma in 100 children. Plast Reconstr Surg 2004;113: 53–60.10.1097/01.PRS.0000099377.84921.E0Search in Google Scholar PubMed
©2015 by De Gruyter
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