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Transient neonatal hyperinsulinism with adaptation disorders: a report of three cases
-
Hiroshi Mizumoto
,
Hiroko Uchio
Published/Copyright:
August 22, 2014
Abstract
Transient hyperinsulinism can occur in neonates following exposure to perinatal stress, such as intrauterine growth restriction and birth asphyxia. However, little is known about its pathophysiology and clinical manifestations. We report three neonatal cases of transient severe hyperinsulinism complicated with cardiopulmonary problems, thrombocytopenia, and marked erythroblastosis at birth. All cases showed signs of placental insufficiency, indicating that chronic hypoxia and malnutrition during fetal development might be associated with characteristic clinical features after birth. Perinatal stress-associated hyperinsulinism can be regarded as a systemic syndrome characterized by cardiopulmonary and hematological problems due to fetal chronic hypoxia.
Keywords: cardiomegaly; erythroblastosis; hyperinsulinemic hypoglycemia; placental insufficiency; pulmonary hypertension; thrombocytopenia
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Received: 2014-3-7
Accepted: 2014-7-14
Published Online: 2014-8-22
Published in Print: 2015-3-1
©2015 by De Gruyter
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Keywords for this article
cardiomegaly;
erythroblastosis;
hyperinsulinemic hypoglycemia;
placental insufficiency;
pulmonary hypertension;
thrombocytopenia
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