Startseite Efficacy of Qurs-e-Gulnar in Ziabetus (type 2 Diabetes Mellitus): a single blind randomized controlled trial
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Efficacy of Qurs-e-Gulnar in Ziabetus (type 2 Diabetes Mellitus): a single blind randomized controlled trial

  • Khalid Eqbal ORCID logo EMAIL logo , Md. Anzar Alam , Mohd Aleemuddin Quamri , Ghulamuddin Sofi und Muzafar Din Ahmad Bhat
Veröffentlicht/Copyright: 18. Juni 2020
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 18 Heft 1

Abstract

Background and objectives

Diabetes is a serious threat to global health that respects neither socioeconomic status nor national boundaries. Globally, diabetes is among the top 10 causes of death. Unani system argued the effectiveness of several anti-hyperglycemic drugs, and all such drugs looked-for to be validated on scientifically. Hence a clinical trial was contemplated to evaluate the clinical efficacy of Qurs-e-Gulnar in the management of Diabetes Mellitus.

Methods

This study was conducted as single blind randomized control, on 40 patients of type 2 diabetes with the test (n=20) and control (n=20) groups for 45 days. Test group received Qurs-e-Gulnar at the dose of three Qurs twice a day, and control group received two capsules Diabeat® twice a day before meal. Subjective (at 0, 15th, 30th, and 45th) and objective parameters were assessed as pre-post treatment respectively.

Results

After treatment with test compound significant reduction was observed in all the subjective parameters viz. polyuria, polydipsia, polyphagia and tiredness in comparison of control group. The objective parameters FBS and PPBS was found to be significantly reduced (p<0.001) in both the groups where as HbA1c was found unchanged in test group but control drug showed highly significant reduction in HbA1c (p<0.001).The results were assessed statistically using two tailed Student’s t-test, and Fischer exact test.

Conclusion

On the basis of above observation it is concluded that the test compound Qurs-e-Gulnar has significant anti-diabetic effect which is evidentially observed both in subjective and objective parameters in test group in comparison of control group (CTRI/2017/07/009060).

Keywords: capsule diabeat®; qurs-e-gulnar; type 2 diabetes mellitus; ziabetus
Corresponding author: Khalid Eqbal, Department of Moalajat, Sufiya Unani Medical College Hospital and Research Centre, Bara Chakia East Champaran, Bihar, India, Phone: +91-8789285025, E-mail:

Acknowledgement

Work is duly acknowledged to our teachers, for valuable suggestion and support throughout the study and especially to human subject who are recruiting for study.

  1. Research Funding: There is no financial support in this study.

  2. Author contributions: Study concept and design: Dr. Khalid Eqbal; drafting of the manuscript; Dr. Md Anzar Alam and Professor Mohd Aleemuddin Quamri; critical revision of the manuscript for imperative rational content; Professor Ghulamuddin Sofi.

  3. Conflict of interest: The authors declare that they have no competing interests.

  4. Employment or leadership: None declared.

  5. Honorarium: None declared.

References

1. Chentli, F, Azzoug, S, Mahgoun, S. Diabetes mellitus in elderly. Indian J Endocrinol Metab 2015 Nov-Dec;19:744–52. https://doi.org/10.26226/morressier.59d5184ad462b80296ca3da9.10.4103/2230-8210.167553Suche in Google Scholar PubMed PubMed Central

2. Association. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018. Diabetes Care 2018;41:S13–27. https://doi.org/10.2337/dc16-er09.10.2337/dc18-S002Suche in Google Scholar PubMed

3. Yuen, L, Saeedi, P, Riaz, M, Karuranga, S, Divakar, H, Levitt, N, et al. Projections of the prevalence of hyperglycaemia in pregnancy in 2019 and beyond: Results from the International Diabetes Federation Diabetes Atlas. Diabetes Research and Clinical Practice 2019;1:157. https://doi.org/10.1016/j.diabres.2019.107841.10.1016/j.diabres.2019.107841Suche in Google Scholar PubMed

4. Rhazi, Z.Al-Hawi Fit Tib. Vol.10.Central Council for Research in Unani Medicine New Delhi: Ministry of Health & Family Welfare, Govt. of India, 2002:181–7.Suche in Google Scholar

5. Majusi, AIA. Kamil Al-San’t. Vol.2, Part-II. Central Council for Research in Unani Medicine New Delhi: Ministry of Health & Family Welfare, Govt. Of India, 2010:192–3.Suche in Google Scholar

6. Sina, I. Al-Qanoon Fit Tib. Vol.3.Urdu Translation by G. Kantoori. Published By Idara Kitab Us Shifa New Delhi: India, 2010:1031–3.Suche in Google Scholar

7. Jurjani, I.Zakhira Kharizm Shahi. Vol.6.Urdu Translation by Hkm. Hadi Husain. Published By Idara Kitab Us Shifa New Delhi: India, 2010:540–1.Suche in Google Scholar

8. Baghdadi, IH. Kitab Al Mukhtarat -fit-Tibb. Vol.3. Central Council for Research in Unani Medicine New Delhi: Ministry of Health & Family Welfare, Govt. of India, 2004:326–8.Suche in Google Scholar

9. Zohr I. Kitab Al-Taiseer. Central Council for Research in Unani Medicine New Delhi: Ministry of Health & Family Welfare, Govt. of India, 1986:160–3.Suche in Google Scholar

10. Papatheodorou, K, Papanas, N, Banach, M, Papazoglou, D, Edmonds, M. Complications of Diabetes 2016.J Diabetes Res 2016;2016:6989453. https://doi.org/10.5005/jp/books/12768.10.1155/2016/6989453Suche in Google Scholar PubMed PubMed Central

11. Chawla, A, Chawla, R, Jaggi, S. Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum? Indian J Endocrinol Metab 2016;20:546–51. https://doi.org/10.4103/2230-8210.183480.10.4103/2230-8210.183480Suche in Google Scholar PubMed PubMed Central

12. Ma, RCW. Epidemiology of diabetes and diabetic complications in China. Diabetologia 2018;61:1249–60. https://doi.org/10.1007/s00125-018-4557-7.10.1007/s00125-018-4557-7Suche in Google Scholar PubMed

13. Cho, NH, Shaw, JE, Karuranga, S, Huang, Y, da Rocha Fernandes, JD, Ohlrogge, AW, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 2018;138:271–81. https://doi.org/10.1016/j.diabres.2018.02.023.10.1016/j.diabres.2018.02.023Suche in Google Scholar PubMed

14. Hirao, K, Maeda, H, Shirabe, SI, Yamamoto, R, Hairo, T, Setsuko, H, et al. Combination Therapy with a Dipeptidyl Peptidase-4 Inhibitor, Sulfonylurea, and Metformin Markedly Improves HbA1c Levels in Japanese Patients with Type 2 Diabetes Mellitus. Jpn Clin Med 2012;3:1–7. https://doi.org/10.4137/jcm.s8571.10.4137/JCM.S8571Suche in Google Scholar PubMed PubMed Central

15. Fauci, AS, Braunwald, E, Kasper, DL, Hauser, SL, Longo, DL, Jameson, JL, et al. Harrison’s Principles of Internal Medicine 17th ed. Vol.2, USA: Mc Graw Hill Companies; 2008.Suche in Google Scholar

16. Standards of Medical Care in Diabetes-2016: Summary of Revisions. Diabetes Care 2016;39:S4–5. https://doi.org/10.2337/dc16-s003.10.2337/dc16-S003Suche in Google Scholar PubMed

17. Chamberlain, JJ, Rhinehart, AS, Shaefer, CFJr, Neuman, A.Diagnosis and Management of Diabetes: Synopsis of the 2016 American Diabetes Association Standards of Medical Care in Diabetes. Ann Intern Med 2016;164:542–52.10.7326/M15-3016Suche in Google Scholar PubMed

18. Lorenzati, B, Zucco, C, Miglietta, S, Lamberti, F, Bruno, G. Oral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of Action.Pharmaceuticals (Basel) 2010;3:3005–20. https://doi.org/10.3390/ph3093005.10.3390/ph3093005Suche in Google Scholar PubMed PubMed Central

19. Samarghandian, S, Azimi-Nezhad, M, Farkhondeh, T.Immunomodulatory and antioxidant effects of saffron aqueous extract (Crocus sativus L.) on streptozotocin-induced diabetes in rats. Indian Heart J 2017;69:151–9. https://doi.org/10.1016/j.ihj.2016.09.008.10.1016/j.ihj.2016.09.008Suche in Google Scholar PubMed PubMed Central

20. Alam, MA, Haider, N, Ahmed, S, Alam, MT, Azeez, A, et al. Tahlab (Spirulina) and few other medicinal plants having anti-oxidant & immunomodulatory properties described in Unani medicine - a review. IJPSR 2013;4:4158–64.Suche in Google Scholar

21. Manukumar, HM, Shiva Kumar, J, Chandrasekhar, B, Raghava, S, Umesha, S. Evidences for diabetes and insulin mimetic activity of medicinal plants: Present status and future prospects. Crit Rev Food Sci Nutr 2017;57:2712–29. https://doi.org/10.1080/10408398.2016.1143446.10.1080/10408398.2016.1143446Suche in Google Scholar PubMed

22. Kabeeruddin, HM. Biyaze Kabeer. Vol-2, Aejaz Publication New Delhi: India, YNM: 109.Suche in Google Scholar

23. Tang, D, Liu, L, Ajiakber, D, Ye, J, Xu, J, Xin, X et al. Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3β and Inhibition of IRE1α-XBP1 Pathways. Front Endocrinol (Lausanne) 2018;9:586. https://doi.org/10.3389/fendo.2018.00586.10.3389/fendo.2018.00586Suche in Google Scholar PubMed PubMed Central

24. Mohammadi, A, Fallah, H, Gholamhosseinian, A. Antihyperglycemic Effect of Rosa Damascena is mediated by PPAR.γ Gene Expression in Animal Model of Insulin Resistance. Iran J Pharm Res 2017;16:1080–8.Suche in Google Scholar

25. Das, S, Barman, S. Antidiabetic and antihyperlipidemic effects of ethanolic extract of leaves of Punica granatum in alloxan-induced non-insulin-dependent diabetes mellitus albino rats. Indian J Pharmacol 2012;44:219–24. https://doi.org/10.4103/0253-7613.93853.10.4103/0253-7613.93853Suche in Google Scholar PubMed PubMed Central

26. Salwe, KJ, Sachdev, DO, Bahurupi, Y, Kumarappan, M. Evaluation of antidiabetic, hypolipedimic and antioxidant activity of hydroalcoholic extract of leaves and fruit peel of Punica granatum in male Wistar albino rats. J Nat Sci Biol Med 2015;6:56–62. https://doi.org/10.4103/0976-9668.149085.10.4103/0976-9668.149085Suche in Google Scholar PubMed PubMed Central

27. Slavov, A, Kiyohara, H, Yamada, H.Immunomodulating pectic polysaccharides from waste rose petals of Rosa damascena Mill. Int J Biol Macromol 2013;59:192–200. https://doi.org/10.1016/j.ijbiomac.2013.04.054.10.1016/j.ijbiomac.2013.04.054Suche in Google Scholar PubMed

28. Celik, I, Temur, A, Isik. Hepatoprotective role and antioxidant capacity of pomegranate (Punica granatum) flowers infusion against trichloroacetic acid-exposed in rats. Food Chem Toxicol 2009;47:145–9. https://doi.org/10.1016/j.fct.2008.10.020.10.1016/j.fct.2008.10.020Suche in Google Scholar PubMed

29. Mohan, M, Patankar, P, Ghadi, P, Kasture, S. Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats. J Pharmacol Pharmacother 2010;1:32–7. https://doi.org/10.4103/0976-500x.64533.10.4103/0976-500X.64533Suche in Google Scholar PubMed PubMed Central

30. Imdad, S, Firdose, KF, Begum, W. Effect of Qurse Gulnar in Heavy menstrual bleeding – a randomized single blind standard control study.IOSR-JDMS 2017:25–31.Suche in Google Scholar

31. Abdullah, Nasiruddin Khan, Kurele Rajeev. Physicochemical Study of a Unani Pharmacopoeal Tablet ‘Qurs-E-Gulnar’. IJR in AYUSH and Pharmaceutical Sciences, 2017;1:21–6.Suche in Google Scholar

32. Suresh, K P, Chandrasekhar, S. Sample Size estimation and Power analysis for Clinical research studies. JRHS 2012;5:7–13. https://doi.org/10.4103/0974-1208.165154.10.4103/0974-1208.97779Suche in Google Scholar PubMed PubMed Central

33. Hameed, I, Masoodi, SR, Mir, SA, Nabi, M, Ghazanfar, K, Ganai, BA. Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition. World J Diabetes 2015;6:598–612. https://doi.org/10.4239/wjd.v6.i4.598.10.4239/wjd.v6.i4.598Suche in Google Scholar

34. Alam, MA, Siddiqui, MA, Quamri, MA. Efficacy and safety of Spirulina in type 2 Diabetes-A Randomized Standard Control Trial. JRUM 2018;7:24–9. https://doi.org/10.1111/dom.13829/v1/review4.10.1111/DOM.13829/v1/review4Suche in Google Scholar

35. Hamasaki, H. Daily physical activity and type 2 diabetes: A review. World J Diabetes 2016 Jun 25;7:243–51. https://doi.org/10.4239/wjd.v7.i12.243.10.4239/wjd.v7.i12.243Suche in Google Scholar

36. Marín-Peñalver, JJ, Martín-Timón, I, Sevillano-Collantes, C, Del Cañizo-Gómez, FJ.Update on the treatment of type 2 diabetes mellitus. World J Diabetes 2016;7:354–95.10.4239/wjd.v7.i17.354Suche in Google Scholar

37. Bharti, SK, Krishnan, S, Kumar, A, Kumar, A. Antidiabetic phytoconstituents and their mode of action on metabolic pathways. Ther Adv Endocrinol Metab 2018;9:81–100. https://doi.org/10.1177/2042018818755019.10.1177/2042018818755019Suche in Google Scholar

38. Patel, DK, Prasad, SK, Kumar, R, Hemalatha, S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed 2012;2:320–30. https://doi.org/10.1016/s2221-1691(12)60032-x.10.1016/S2221-1691(12)60032-XSuche in Google Scholar

39. Ali, W, Shaikh, H, Ansari, A, Khanam, S. Standardization of Unani Antidiabetic Tablet - Qurse Tabasheer. Pharmacognosy Res 2016;8:147–52. https://doi.org/10.4103/0974-8490.175611.10.4103/0974-8490.175611Suche in Google Scholar PubMed PubMed Central

40. Ghani, HN, Khazainul Advia. (Urdu). New Delhi: Published By Idara Kitab-Us-Shifa, India, 2010:254,340–1, 1022–3, 1127, 1133–6, 1138.Suche in Google Scholar

41. Baitar, I. Al-Jame’ Le Mufradat Al-Advia Wa Al-Aghzia (Urdu). Vol.2 & 4. New Delhi: Central Council for Research in Unani Medicine. Ministry of Health & Family Welfare Govt of India, 2003:135–6,300–4,416–9.Suche in Google Scholar

42. Kabiruddin, H.Makhzan Al Mufradat. Published By Aejaz Publishing House. India,YNM:82–3,118–9,444–5,485–6, 489–90, 94–5.Suche in Google Scholar

43. Hakeem, MAH. Bustan ul Mufradat. New Delhi: Idarae Kitabul Shifa India, 1999:64,88,246,278,280.Suche in Google Scholar

44. Zarfeshany, A, Asgary, S, Javanmard, SH. Potent health effects of pomegranate. Adv Biomed Res 2014;3:100. https://doi.org/10.4103/2277-9175.129371.10.4103/2277-9175.129371Suche in Google Scholar PubMed PubMed Central

45. Mahboubi, M. Rosa damascena as holy ancient herb with novel applications. J Tradit Complement Med 2016;6:10–6. https://doi.org/10.1016/j.jtcme.2015.09.005.10.1016/j.jtcme.2015.09.005Suche in Google Scholar PubMed PubMed Central

46. Huang, TH, Peng, G, Kota, BP, Li, GQ, Yamahara, J, Roufogalis, BD, Li, Y. Anti-diabetic action of Punica granatum flower extract: activation of PPAR-gamma and identification of an active component. Toxicol Appl Pharmacol 2005;207:160–9. https://doi.org/10.1016/j.taap.2004.12.009.10.1016/j.taap.2004.12.009Suche in Google Scholar PubMed

47. Gholamhoseinian, A, Fallah, H, Sharifi far, F. Inhibitory effect of methanol extract of Rosa damascena Mill. Flowers on alpha-glycosidase activity and postprandial hyperglycemia in normal and diabetic rats. Phytomedicine 2009;16:935–41. https://doi.org/10.1016/j.phymed.2009.02.020.10.1016/j.phymed.2009.02.020Suche in Google Scholar

48. Li, Y, Wen, S, Kota, BP, Peng, G, Li, GQ, Yamahara, J, Roufogalis, BD. Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. J Ethnopharmacol 2005;99:239–44. https://doi.org/10.1016/j.jep.2005.02.030.10.1016/j.jep.2005.02.030Suche in Google Scholar

49. Gunindro, N, Devi, KP, Singh, TI. Effects of Acacia catechu on intestinal absorption of glucose in rats. J. Chem. Pharm. Res 2013;5:78–81.Suche in Google Scholar

50. Jafri, MA, Aslam, M, Javed, K, Singh, S. Effect of Punica granatum Linn. (Flowers) on blood glucose level in normal and alloxan-induced diabetic rats. J Ethnopharmacol 2000;70:309–14. https://doi.org/10.1016/s0378-8741(99)00170-1.10.1016/S0378-8741(99)00170-1Suche in Google Scholar

51. Saha, MR, Dey, P, Sarkar, I, De Sarker, D, Haldar, B, Chaudhuri, TK, Sen, A. Acacia nilotica leaf improves insulin resistance and hyperglycemia associated acute hepatic injury and nephrotoxicity by improving systemic antioxidant status in diabetic mice. J Ethnopharmacol 2018;210:275–86. https://doi.org/10.1016/j.jep.2017.08.036.10.1016/j.jep.2017.08.036Suche in Google Scholar PubMed

52. Hegazy, GA, Alnoury, AM, Gad, HG. The role of Acacia Arabica extract as an antidiabetic, antihyperlipidemic, and antioxidant in streptozotocin-induced diabetic rats. Saudi Med J 2013;34:727–33.Suche in Google Scholar

Received: 2020-03-08
Accepted: 2020-04-02
Published Online: 2020-06-18

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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  13. Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide-induced anaemia in rats
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https://doi.org/10.1515/jcim-2020-0072
Schlagwörter für diesen Artikel
capsule diabeat®; qurs-e-gulnar; type 2 diabetes mellitus; ziabetus

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Endocannabinoids release after Osteopathic Manipulative Treatment. A brief review
  4. A pervasive scientific overview on mangiferin in the prevention and treatment of various diseases with preclinical and clinical updates
  5. Clinical trials of homeopathy in urological disorders: a systematic review
  6. Strategies in traditional Persian medicine to maintain a healthy life in the elderly
  7. Research articles Basic
  8. Cytoprotective and antisecretory properties of methanolic extract of Distemonanthus benthamianus (Caesalpiniaceae) stem bark on acute gastric ulcer in rats
  9. Screening chemical inhibitors for alpha-amylase from leaves extracts of Murraya koenigii (Linn.) and Aegle marmelos L.
  10. Ayurvedic formulations containing benzoic and ascorbic acids as additives: benzene formation during storage and impact of additives on quality parameters
  11. High cholesterol diet promotes dysfunction of arginase and cholinergic enzymatic system in rats: ameliorative role of caffeic and chlorogenic acids
  12. Cytokine and inflammatory mediators are associated with cytotoxic, anti-inflammatory and apoptotic activity of honeybee venom
  13. Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide-induced anaemia in rats
  14. Alterations in histological, biochemical and hematological parameters in Plasmodium berghei NK-65 infected balb/c mice treated with Bridelia ferruginea stem bark extract
  15. Structural characterization, antioxidant, and antibiofilm activities of Coffea canephora green seeds
  16. Research articles Clinical
  17. Safety, efficacy and tolerability of a combination micronutrient and polyherbal preparation (GoutFighterTM) for gout: a single-arm open-label pilot study
  18. Efficacy of Habbul aas (fruits of Myrtus communis) in menorrhagia: a single blinded randomized standard control study
  19. Ginger (Zingiber officinale) and turmeric (Curcuma longa L.) supplementation effects on quality of life, body composition, bone mineral density and osteoporosis related biomarkers and micro-RNAs in women with postmenopausal osteoporosis: a study protocol for a randomized controlled clinical trial
  20. Lithotriptic effect of Safūf Hajar-al Yahūd in patients of Hasat-ul Kilya (Nephrolithiasis) – an open prospective clinical validation trial
  21. Efficacy of Qurs-e-Gulnar in Ziabetus (type 2 Diabetes Mellitus): a single blind randomized controlled trial
  22. Immediate effect of Kapalbhathi pranayama on short term heart rate variability (HRV) in healthy volunteers
  23. Designing and validation of a yoga-based module for obesity with metabolic comorbidities
  24. A mixed-method randomized feasibility trial evaluating progressive muscle relaxation or autogenic training on depressive symptoms and quality of life in people living with human immunodeficiency virus (HIV) who have depressive symptoms
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  28. Improvement in resilience and stress-related blood markers following ten months yoga practice in Antarctica
  29. Neutral douche: a hydrotherapeutic tool to manage pain and systemic symptoms in primary dysmenorrhea - a randomised controlled study
  30. Short Communication
  31. The effects of omega-3 on the sleep quality of patients with uremic pruritus undergoing hemodialysis: a randomized crossover study
  32. Case Reports
  33. Āyuṛveda management of keratosis pilaris – a case report
  34. Improvement in impaired ocular accommodation by parietal acupoint therapy to relieve neck stiffness: a case report
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