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Efficacy of Qurs-e-Gulnar in Ziabetus (type 2 Diabetes Mellitus): a single blind randomized controlled trial

  • Khalid Eqbal ORCID logo EMAIL logo , Md. Anzar Alam , Mohd Aleemuddin Quamri , Ghulamuddin Sofi and Muzafar Din Ahmad Bhat
Published/Copyright: June 18, 2020
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 18 Issue 1

Abstract

Background and objectives

Diabetes is a serious threat to global health that respects neither socioeconomic status nor national boundaries. Globally, diabetes is among the top 10 causes of death. Unani system argued the effectiveness of several anti-hyperglycemic drugs, and all such drugs looked-for to be validated on scientifically. Hence a clinical trial was contemplated to evaluate the clinical efficacy of Qurs-e-Gulnar in the management of Diabetes Mellitus.

Methods

This study was conducted as single blind randomized control, on 40 patients of type 2 diabetes with the test (n=20) and control (n=20) groups for 45 days. Test group received Qurs-e-Gulnar at the dose of three Qurs twice a day, and control group received two capsules Diabeat® twice a day before meal. Subjective (at 0, 15th, 30th, and 45th) and objective parameters were assessed as pre-post treatment respectively.

Results

After treatment with test compound significant reduction was observed in all the subjective parameters viz. polyuria, polydipsia, polyphagia and tiredness in comparison of control group. The objective parameters FBS and PPBS was found to be significantly reduced (p<0.001) in both the groups where as HbA1c was found unchanged in test group but control drug showed highly significant reduction in HbA1c (p<0.001).The results were assessed statistically using two tailed Student’s t-test, and Fischer exact test.

Conclusion

On the basis of above observation it is concluded that the test compound Qurs-e-Gulnar has significant anti-diabetic effect which is evidentially observed both in subjective and objective parameters in test group in comparison of control group (CTRI/2017/07/009060).

Keywords: capsule diabeat®; qurs-e-gulnar; type 2 diabetes mellitus; ziabetus
Corresponding author: Khalid Eqbal, Department of Moalajat, Sufiya Unani Medical College Hospital and Research Centre, Bara Chakia East Champaran, Bihar, India, Phone: +91-8789285025, E-mail:

Acknowledgement

Work is duly acknowledged to our teachers, for valuable suggestion and support throughout the study and especially to human subject who are recruiting for study.

  1. Research Funding: There is no financial support in this study.

  2. Author contributions: Study concept and design: Dr. Khalid Eqbal; drafting of the manuscript; Dr. Md Anzar Alam and Professor Mohd Aleemuddin Quamri; critical revision of the manuscript for imperative rational content; Professor Ghulamuddin Sofi.

  3. Conflict of interest: The authors declare that they have no competing interests.

  4. Employment or leadership: None declared.

  5. Honorarium: None declared.

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Received: 2020-03-08
Accepted: 2020-04-02
Published Online: 2020-06-18

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jcim-2020-0072
Keywords for this article
capsule diabeat®; qurs-e-gulnar; type 2 diabetes mellitus; ziabetus

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Endocannabinoids release after Osteopathic Manipulative Treatment. A brief review
  4. A pervasive scientific overview on mangiferin in the prevention and treatment of various diseases with preclinical and clinical updates
  5. Clinical trials of homeopathy in urological disorders: a systematic review
  6. Strategies in traditional Persian medicine to maintain a healthy life in the elderly
  7. Research articles Basic
  8. Cytoprotective and antisecretory properties of methanolic extract of Distemonanthus benthamianus (Caesalpiniaceae) stem bark on acute gastric ulcer in rats
  9. Screening chemical inhibitors for alpha-amylase from leaves extracts of Murraya koenigii (Linn.) and Aegle marmelos L.
  10. Ayurvedic formulations containing benzoic and ascorbic acids as additives: benzene formation during storage and impact of additives on quality parameters
  11. High cholesterol diet promotes dysfunction of arginase and cholinergic enzymatic system in rats: ameliorative role of caffeic and chlorogenic acids
  12. Cytokine and inflammatory mediators are associated with cytotoxic, anti-inflammatory and apoptotic activity of honeybee venom
  13. Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide-induced anaemia in rats
  14. Alterations in histological, biochemical and hematological parameters in Plasmodium berghei NK-65 infected balb/c mice treated with Bridelia ferruginea stem bark extract
  15. Structural characterization, antioxidant, and antibiofilm activities of Coffea canephora green seeds
  16. Research articles Clinical
  17. Safety, efficacy and tolerability of a combination micronutrient and polyherbal preparation (GoutFighterTM) for gout: a single-arm open-label pilot study
  18. Efficacy of Habbul aas (fruits of Myrtus communis) in menorrhagia: a single blinded randomized standard control study
  19. Ginger (Zingiber officinale) and turmeric (Curcuma longa L.) supplementation effects on quality of life, body composition, bone mineral density and osteoporosis related biomarkers and micro-RNAs in women with postmenopausal osteoporosis: a study protocol for a randomized controlled clinical trial
  20. Lithotriptic effect of Safūf Hajar-al Yahūd in patients of Hasat-ul Kilya (Nephrolithiasis) – an open prospective clinical validation trial
  21. Efficacy of Qurs-e-Gulnar in Ziabetus (type 2 Diabetes Mellitus): a single blind randomized controlled trial
  22. Immediate effect of Kapalbhathi pranayama on short term heart rate variability (HRV) in healthy volunteers
  23. Designing and validation of a yoga-based module for obesity with metabolic comorbidities
  24. A mixed-method randomized feasibility trial evaluating progressive muscle relaxation or autogenic training on depressive symptoms and quality of life in people living with human immunodeficiency virus (HIV) who have depressive symptoms
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