Lithotriptic effect of Safūf Hajar-al Yahūd in patients of Hasat-ul Kilya (Nephrolithiasis) – an open prospective clinical validation trial

Noor Zaheer Ahmed; Kabiruddin Ahmed; Noman Anwar; Radhakrishnan Ezhil; Nighat Anjum; Asim Ali Khan

doi:10.1515/jcim-2019-0301

Article

Lithotriptic effect of Safūf Hajar-al Yahūd in patients of Hasat-ul Kilya (Nephrolithiasis) – an open prospective clinical validation trial

Noor Zaheer Ahmed , Kabiruddin Ahmed , Noman Anwar , Radhakrishnan Ezhil , Nighat Anjum and Asim Ali Khan

Published/Copyright: May 19, 2020

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From the journal Journal of Complementary and Integrative Medicine Volume 18 Issue 1

Abstract

Background

Hasat-ul Kilya (Nephrolithiasis) is one of the most common chronic conditions and has been known to the mankind since antiquity. The incidence is increasing globally with geographic, racial and gender variation in its occurrence. Medical management of Nephrolithiasis still poses a considerable challenge for modern medical practice. Unani drugs possessing lithotriptic activity are not only cost effective but also have least side effects. Safūf Hajar-al Yahūd has been used since long for the treatment of Hasat-ul Kilya (Nephrolithiasis) but no documentary evidence based on scientific parameters as to its safety and efficacy are available.

Objective

To validate the safety and efficacy of Safūf Hajar-al Yahūd in the treatment of Hasat-ul Kilya.

Methodology

An open prospective clinical trial was carried out on 107 subjects of renal calculi of 3–7 mm diameter diagnosed by Ultrasonogram-KUB (USG-KUB). Subjects were evaluated by clinical history & examination, laboratory investigations followed by USG-KUB for confirmation. The safety was assessed by reporting of adverse events and by pathological and biochemical investigations. Assessment of efficacy was based on improvement observed in VAS score and expulsion/reduction of stone size as detected by USG-KUB.

Results

Substantial reduction (53%) in the size of calculi confirmed by USG-KUB and considerable lowering of VAS score (75%) were observed with the active intervention in majority of the cases

Conclusion

The trial has revealed that the Unani pharmacopoeal formulation Safūf Hajar-al Yahūd was well tolerated and has the therapeutic potential in the reduction and expulsion of renal calculi.

Keywords: Hasat-ul Kilya; Nephrolithiasis; renal stones; Safuf Hajrul Yahood; Unani pharmacopoeal formulation

Corresponding author: Noor Zaheer Ahmed, Head of Institute, Research Officer (U) Scientist IV, Regional Research Institute of Unani Medicine, Chennai, 600013, India; and Central Council for Research in Unani Medicine, New Delhi, Ministry of AYUSH, Govt of India,India. Mobile: 9884764658, drnzaheer@gmail.com

Funding source: Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy

Acknowledgements

The authors are grateful to the M/o AYUSH, Govt of India for sponsoring and allotting the study to R.R.I.U.M, Chennai. The authors also duly acknowledge the contribution of a team of C.C.R.U.M Officers for their role in study protocol preparation. The authors also duly acknowledge Dr. Sheila Sathiya Kumar, Sonologist, Hibeam Scans, Roypuram, Chennai for their valuable contribution.

Research funding: The study has been entirely funded by Central Council for Research in Unani Medicine (CCRUM), New Delhi, Ministry of AYUSH, Government of India.
Author contributions: All the authors have accepted the responsibility for the entire content of the submitted manuscript and approved submission.
Competing interests: Funding organization played no role in the study design, in the collection, analysis and interpretation of data, in the writing of report or in the decision to submit the report for publication.

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Received: 2019-12-24

Accepted: 2020-03-09

Published Online: 2020-05-19

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Articles in the same Issue

https://doi.org/10.1515/jcim-2019-0301

Keywords for this article

Hasat-ul Kilya; Nephrolithiasis; renal stones; Safuf Hajrul Yahood; Unani pharmacopoeal formulation