Startseite Medizin Ameliorative effect of morin on dutasteride-tamsulosin-induced testicular oxidative stress in rat
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Ameliorative effect of morin on dutasteride-tamsulosin-induced testicular oxidative stress in rat

  • Ebenezer Tunde Olayinka und Kayode Ezekiel Adewole ORCID logo EMAIL logo
Veröffentlicht/Copyright: 23. Dezember 2020
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 18 Heft 2

Abstract

Objectives

Dutasteride-Tamsulosin (DUT-TAM), a drug of choice for the treatment of prostate enlargement (Benign Prostatic Hyperplasia, BPH) has been implicated in testicular toxicity. This study investigated the protective effect of morin, a plant-derived flavonoid on DUT-TAM-induced testicular toxicity in Wistar rat.

Methods

Twenty-four male Wistar rats (110–140 g) were randomly divided into four treatment groups (n=6). Group A animals served as the control and were administered olive oil, Group B animals were administered 5.4 mg/kg b.w. of dutasteride + 3.4 mg/kg b.w of tamsulosin., Group C animals were administered 100 mg/kg b.w. of morin, while Group D animals were administered DUT-TAM (5.4 mg/kg b.w. of dutasteride + 3.4 mg/kg b.w. of tamsulosin) and morin (100 mg/kg b.w.). The administration lasted for two weeks.

Results

DUT-TAM-induced abnormal sperm morphology (31.8%), significantly reduced (p<0.05) sperm count, sperm motility, live-dead sperm ratio, testicular superoxide dismutase (SOD), catalase, glutathione-S-transferase (GST) and acid phosphatase (ACP) activities, as well as the levels of ascorbic acid and reduced glutathione (GSH) which were ameliorated by co-treatment with morin. Also, DUT-TAM-induced increase in testicular malondialdehyde level and the activities of alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT) and lactate dehydrogenase (LDH) were significantly reversed (p<0.05) by co-treatment with morin.

Conclusions

These results indicated the protective ability of morin against Dutasteride-Tamsulosin-induced testicular toxicity and oxidative stress.

Keywords: dutasteride; oxidative stress; prostate enlargement; tamsulosin; testis
Corresponding author: Kayode Ezekiel Adewole, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Medical SciencesOndo, Ondo State,Nigeria, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication

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Received: 2019-07-05
Accepted: 2020-08-31
Published Online: 2020-12-23

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis
  4. Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis
  5. Raising burden of non-communicable diseases: importance of integrating Yoga and Naturopathy at primary care level
  6. Research Articles Basic
  7. Marketing and legal status of phytomedicines and food supplements in Morocco
  8. Hydrogen sulfide as a mediator of endothelium-dependent relaxation evoked by Moringa oleifera leaf extract in mesenteric arterial beds isolated from L-NAME hypertensive rats
  9. Acute and sub-acute toxicity assessment of aqueous leaves extract of Crassocephalum crepidioides (Asteraceae) in Wistar rats
  10. Zingerone improves the immune responses in an animal model of breast cancer
  11. Evaluation of efficacy of Bombax ceiba extract and its major constituent, mangiferin in streptozotocin (STZ)-induced diabetic rats
  12. Bacterial endosymbiont inhabiting Leucaena leucocephala leaves and their antioxidant and antidiabetic potential
  13. Ameliorative effect of morin on dutasteride-tamsulosin-induced testicular oxidative stress in rat
  14. The potentiation of beta-lactam and anti-bacterial activities of lipophilic constituents from Mesua ferrae leaves against methicillin-resistant Staphylococcus aureus
  15. Influence of irisin on diet-induced metabolic syndrome in experimental rat model
  16. Modulatory effect of methanol extract of Annona muricata stem bark on mitochondrial membrane permeability transition pore in normal rat liver and monosodium glutamate-induced uterine hyperplasia
  17. Research Articles Clinical
  18. Functional status in adhesive capsulitis – yoga vs. physiotherapy: a quasi experimental study
  19. Okada Purifying Therapy in combination with duloxetine vs. duloxetine alone in patients with TMD and fibromyalgia: a randomized clinical study
  20. The FIFA 11+ does not alter performance in amateur female basketball players—a randomized control trial
  21. Body composition, phenotype and central obesity indices in Egyptian women with non-alcoholic fatty liver disease
  22. Immediate effect of interscapular cupping on blood pressure, oxygen saturation, pulse rate and chest expansion in sedentary smoker students
  23. The effects of an olive-oil massage on hemodialysis patients suffering from fatigue at a hemodialysis unit in southern India – a randomized controlled trial
  24. Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial
  25. The effect of practicing yoga during pregnancy on labor stages length, anxiety and pain: a randomized controlled trial
  26. Effect of lumbar stabilization exercises and thoracic mobilization with strengthening exercises on pain level, thoracic kyphosis, and functional disability in chronic low back pain
  27. A prospective controlled study on Ramadan fasting in the healthy young males in summer in Germany: effect on cytokines
  28. Tualang honey versus steroid impregnated nasal dressing following endoscopic sinus surgery: a randomized controlled trial
  29. Short Communications
  30. Improved anti-arthritic activity of ginger extract, a traditional medicine, using novel drug delivery approach
  31. Efficacy of fenugreek seed extract on men's psychological and physical health: a randomized placebo-controlled double-blind clinical trial
https://doi.org/10.1515/jcim-2019-0160
Schlagwörter für diesen Artikel
dutasteride; oxidative stress; prostate enlargement; tamsulosin; testis

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis
  4. Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis
  5. Raising burden of non-communicable diseases: importance of integrating Yoga and Naturopathy at primary care level
  6. Research Articles Basic
  7. Marketing and legal status of phytomedicines and food supplements in Morocco
  8. Hydrogen sulfide as a mediator of endothelium-dependent relaxation evoked by Moringa oleifera leaf extract in mesenteric arterial beds isolated from L-NAME hypertensive rats
  9. Acute and sub-acute toxicity assessment of aqueous leaves extract of Crassocephalum crepidioides (Asteraceae) in Wistar rats
  10. Zingerone improves the immune responses in an animal model of breast cancer
  11. Evaluation of efficacy of Bombax ceiba extract and its major constituent, mangiferin in streptozotocin (STZ)-induced diabetic rats
  12. Bacterial endosymbiont inhabiting Leucaena leucocephala leaves and their antioxidant and antidiabetic potential
  13. Ameliorative effect of morin on dutasteride-tamsulosin-induced testicular oxidative stress in rat
  14. The potentiation of beta-lactam and anti-bacterial activities of lipophilic constituents from Mesua ferrae leaves against methicillin-resistant Staphylococcus aureus
  15. Influence of irisin on diet-induced metabolic syndrome in experimental rat model
  16. Modulatory effect of methanol extract of Annona muricata stem bark on mitochondrial membrane permeability transition pore in normal rat liver and monosodium glutamate-induced uterine hyperplasia
  17. Research Articles Clinical
  18. Functional status in adhesive capsulitis – yoga vs. physiotherapy: a quasi experimental study
  19. Okada Purifying Therapy in combination with duloxetine vs. duloxetine alone in patients with TMD and fibromyalgia: a randomized clinical study
  20. The FIFA 11+ does not alter performance in amateur female basketball players—a randomized control trial
  21. Body composition, phenotype and central obesity indices in Egyptian women with non-alcoholic fatty liver disease
  22. Immediate effect of interscapular cupping on blood pressure, oxygen saturation, pulse rate and chest expansion in sedentary smoker students
  23. The effects of an olive-oil massage on hemodialysis patients suffering from fatigue at a hemodialysis unit in southern India – a randomized controlled trial
  24. Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial
  25. The effect of practicing yoga during pregnancy on labor stages length, anxiety and pain: a randomized controlled trial
  26. Effect of lumbar stabilization exercises and thoracic mobilization with strengthening exercises on pain level, thoracic kyphosis, and functional disability in chronic low back pain
  27. A prospective controlled study on Ramadan fasting in the healthy young males in summer in Germany: effect on cytokines
  28. Tualang honey versus steroid impregnated nasal dressing following endoscopic sinus surgery: a randomized controlled trial
  29. Short Communications
  30. Improved anti-arthritic activity of ginger extract, a traditional medicine, using novel drug delivery approach
  31. Efficacy of fenugreek seed extract on men's psychological and physical health: a randomized placebo-controlled double-blind clinical trial
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