Home Medicine The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis
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The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis

  • Sanaz Malekian , Nafiseh Ghassab-Abdollahi , Mojgan Mirghafourvand and Azizeh Farshbaf-Khalili EMAIL logo
Published/Copyright: January 5, 2021
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 18 Issue 2

Abstract

Objectives

The present systematic review of literature was conducted to study the effect of Nigella sativa (N.S) on oxidative stress and inflammatory biomarkers.

Content

Different online databases such as Cochrane Central Register of Controlled Trials, MEDLINE (PubMed), Scopus, Web of Sciences, EMBASE, and Clininaltrial.gov for English articles and national databases of SID, Magiran, Irandoc, and Iranmedex for Persian articles, which were published until March; 2019 were scrutinized. All Randomised Controlled Trials (RCTs) and quasi-experimental studies that aimed to compare the impact of N.S along, with placebo or without supplementation, on inflammatory factors and oxidative stress were entered in the present study.

Summary

Finally, 11 RCTs covering 710 women and men, in total, were participated in the present meta-analysis. Significant differences were observed in Tumor Necrosis Factor alpha (TNF-α) (Weighted Mean Difference (WMD) =−2.15 pg/mL, 95% Confidence Interval (CI) =−3.22–−1.09, I2=32%; 5 trials with 262 participants) superoxide dismutase (WMD=63.79 µ/gHb, 95% CI=6.84–120.75, I2=0%; 2 trials, with 88 participants), and total antioxidant capacity (WMD=0.34 mmol/L, 95% CI=0.04 to 0.63, I2=94%; 5 trials with 232 participants). Nevertheless, there was no significant difference in high sensitivity C-reactive protein (WMD=−0.98 mg/L, 95% CI=−1.98–0.03, I2=78%; 5 trials with 267 participants), Interleukin 6 (IL-6) (WMD=−0.25 pg/mL, 95% CI=−0.65 to 0.16, I2=0%; 2 trials with 134 participants), and malondialdehyde (WMD=−0.95 nmol/mL, 95% CI=−1.97–0.08, I2=68%; 4 trials with 179 participants).

Outlook

Generally speaking, N.S probably results in the improvement of superoxide dismutase serum levels, TNF-α, and total antioxidant capacity. Thus, further studies are required to fully assess its impacts on all oxidative stress and inflammatory biomarkers.

Keywords: inflammatory biomarkers; meta-analysis; Nigella sativa; oxidative stress; supplementation; systematic review
Corresponding author: Azizeh Farshbaf-Khalili, Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran, Phone: 00989144023216, Fax: + 984134796969, E-mail:

Acknowledgments

This study was extracted from a master’s thesis (in progress) approved by the Ethics Committee of Tabriz University of Medical Sciences under No. IR. TBZMED. REC.139 7.733. We thank the Vice Chancellor for Research and Technology at Tabriz University of Medical Sciences for their financial support, also Mrs Bakhtiarai at physical medicine and rehabilitation research center of Tabriz University of Medical Sciences for their assistance with this study.

  1. Research funding: This article was financially supported by Tabriz University of Medical Sciences.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors have no conflict to declare.

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Received: 2019-09-02
Accepted: 2020-08-11
Published Online: 2021-01-05

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis
  4. Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis
  5. Raising burden of non-communicable diseases: importance of integrating Yoga and Naturopathy at primary care level
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  12. Bacterial endosymbiont inhabiting Leucaena leucocephala leaves and their antioxidant and antidiabetic potential
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  14. The potentiation of beta-lactam and anti-bacterial activities of lipophilic constituents from Mesua ferrae leaves against methicillin-resistant Staphylococcus aureus
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  25. The effect of practicing yoga during pregnancy on labor stages length, anxiety and pain: a randomized controlled trial
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  27. A prospective controlled study on Ramadan fasting in the healthy young males in summer in Germany: effect on cytokines
  28. Tualang honey versus steroid impregnated nasal dressing following endoscopic sinus surgery: a randomized controlled trial
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https://doi.org/10.1515/jcim-2019-0198
Keywords for this article
inflammatory biomarkers; meta-analysis; Nigella sativa; oxidative stress; supplementation; systematic review

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis
  4. Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis
  5. Raising burden of non-communicable diseases: importance of integrating Yoga and Naturopathy at primary care level
  6. Research Articles Basic
  7. Marketing and legal status of phytomedicines and food supplements in Morocco
  8. Hydrogen sulfide as a mediator of endothelium-dependent relaxation evoked by Moringa oleifera leaf extract in mesenteric arterial beds isolated from L-NAME hypertensive rats
  9. Acute and sub-acute toxicity assessment of aqueous leaves extract of Crassocephalum crepidioides (Asteraceae) in Wistar rats
  10. Zingerone improves the immune responses in an animal model of breast cancer
  11. Evaluation of efficacy of Bombax ceiba extract and its major constituent, mangiferin in streptozotocin (STZ)-induced diabetic rats
  12. Bacterial endosymbiont inhabiting Leucaena leucocephala leaves and their antioxidant and antidiabetic potential
  13. Ameliorative effect of morin on dutasteride-tamsulosin-induced testicular oxidative stress in rat
  14. The potentiation of beta-lactam and anti-bacterial activities of lipophilic constituents from Mesua ferrae leaves against methicillin-resistant Staphylococcus aureus
  15. Influence of irisin on diet-induced metabolic syndrome in experimental rat model
  16. Modulatory effect of methanol extract of Annona muricata stem bark on mitochondrial membrane permeability transition pore in normal rat liver and monosodium glutamate-induced uterine hyperplasia
  17. Research Articles Clinical
  18. Functional status in adhesive capsulitis – yoga vs. physiotherapy: a quasi experimental study
  19. Okada Purifying Therapy in combination with duloxetine vs. duloxetine alone in patients with TMD and fibromyalgia: a randomized clinical study
  20. The FIFA 11+ does not alter performance in amateur female basketball players—a randomized control trial
  21. Body composition, phenotype and central obesity indices in Egyptian women with non-alcoholic fatty liver disease
  22. Immediate effect of interscapular cupping on blood pressure, oxygen saturation, pulse rate and chest expansion in sedentary smoker students
  23. The effects of an olive-oil massage on hemodialysis patients suffering from fatigue at a hemodialysis unit in southern India – a randomized controlled trial
  24. Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial
  25. The effect of practicing yoga during pregnancy on labor stages length, anxiety and pain: a randomized controlled trial
  26. Effect of lumbar stabilization exercises and thoracic mobilization with strengthening exercises on pain level, thoracic kyphosis, and functional disability in chronic low back pain
  27. A prospective controlled study on Ramadan fasting in the healthy young males in summer in Germany: effect on cytokines
  28. Tualang honey versus steroid impregnated nasal dressing following endoscopic sinus surgery: a randomized controlled trial
  29. Short Communications
  30. Improved anti-arthritic activity of ginger extract, a traditional medicine, using novel drug delivery approach
  31. Efficacy of fenugreek seed extract on men's psychological and physical health: a randomized placebo-controlled double-blind clinical trial
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