Adrenocorticotropic hormone (ACTH) level and adrenal deficiency in patients with mucocutaneous pemphigus
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Mohammadreza Salehi
Abstract
Objectives
This study aimed to evaluate the level of adrenocorticotropic hormone (ACTH) and adrenal insufficiency in patients with mucocutaneous pemphigus lesions who use oral corticosteroids.
Methods
This descriptive-analytical study was performed on 54 patients (48.44 ± 12.74 years) with mucocutaneous pemphigus in 2019. Those patients taken corticosteroids in different doses and way. At first, collected patients information including age, sex, type of pemphigus, duration of use, patient dosage, duration of corticosteroid administration, and method of administration were collected daily. Adrenal gland function was measured by evaluating ACTH levels. Data were analyzed by using Pearson correlation coefficient and t-test.
Results
Our study showed that 37 cases (68.5%) had normal ACTH average hormone level (7.3–63.3 mL/pg), 11 cases (20.4%) were lower levels (<7.2 mL/pg), and 6 cases (11.1%) were higher levels (63.3 > mL/pg). Wo observed no significant relationship between ACTH and duration of corticosteroids usage (p=0.207).
Conclusions
Taking a maintenance dose of between 12.5 and 25 mg daily does not usually lead to adrenal insufficiency. The present study showed that the lower the daily dose of corticosteroids, the lower the likelihood of adrenal insufficiency.
Funding source: Isfahan University of Medical Sciences
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Research funding: This study was supported by the Isfahan University of Medical Sciences, Isfahan, Iran.
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Author contributions: The authors contribution to the paper is as follow MS: study concepts and design, data analysis and interpretation, statistical analysis, obtaining funding, critical revision of the manuscript for important intellectual content and manuscript preparation; ZS: data analysis; MR: biochemical studies and data analysis; IL and EF: biochemical studies and data analysis. All authors read and approved the final manuscript.
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Competing interests: The authors declare no conflict of interest with potential applications or effects of the results of this research.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The procedures employed were in keeping with the principles of the Institutional Committee on Ethics in Human Research and the Declaration of Helsinki of 1964 and subsequent modifications. The ethical code was IR.MUI.RESEARCH.REC.1398.164.
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Data availability: The raw data supporting the conclusions of this manuscript will be made available upon request.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
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- Letter to the Editor
- COVID-19 pandemic: transmission of SARS-CoV-2 in animals, a risk for human beings
- Original Articles
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- Selective estrogen receptor α and β antagonist aggravate cardiovascular dysfunction in type 2 diabetic ovariectomized female rats
- Adrenocorticotropic hormone (ACTH) level and adrenal deficiency in patients with mucocutaneous pemphigus
- The effect of resistance training on serum levels of sex hormones and sperm quality in male rats under X-ray radiation
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Artikel in diesem Heft
- Frontmatter
- Letter to the Editor
- COVID-19 pandemic: transmission of SARS-CoV-2 in animals, a risk for human beings
- Original Articles
- Anti Mullerian hormone as a diagnostic tool for polycystic ovary syndrome in women of reproductive age with morbid obesity
- Potential tumor marker for hepatocellular carcinoma identification: PI3K and pro-inflammatory cytokines (TGF-β, IL-1, and IL-6)
- The investigation of the frequency of the alpha-1-antitrypsin phenotype in patients with liver cirrhosis
- Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1α/SIRT3– independent GPx1 expression in the heart of mice with endometriosis
- Hypoxia-inducible factor-1α and ischemia-modified albumin levels in intensive care COVID-19 Patients
- Association between TP53 Arg72Pro variant and recurrent pregnancy loss in the Greek population
- Selective estrogen receptor α and β antagonist aggravate cardiovascular dysfunction in type 2 diabetic ovariectomized female rats
- Adrenocorticotropic hormone (ACTH) level and adrenal deficiency in patients with mucocutaneous pemphigus
- The effect of resistance training on serum levels of sex hormones and sperm quality in male rats under X-ray radiation
- The effect of high-intensity interval training on serum and adipose tissues vaspin levels in rats fed a high-fat high-sucrose diet
- Anti-migratory effect of curcumin on A-549 lung cancer cells via epigenetic reprogramming of RECK/ matrix metalloproteinase axis
- Efficacy of rectal progesterone on maternal and neonatal outcomes in pregnant women with Preterm Premature Rupture of membranes: a triple-blind randomised clinical trial
- Case Report
- Ovarian tissue cryopreservation in Malaysia: a case series
- Review Articles
- An overview of prognostic value of neurologic and cardiac biomarkers in patients with COVID-19 sequelae
- Potential role of melatonin in prevention and treatment of lung cancer
- Esketamine–A quick-acting novel antidepressant without the disadvantages of ketamine
