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An overview of prognostic value of neurologic and cardiac biomarkers in patients with COVID-19 sequelae

  • Madhusudhan Umesh EMAIL logo , Vidya Singaravelu , Vandana Daulatabad , Prafull Kamble , Anish Singhal , Nitin Ashok John ORCID logo and Jyoti John
Published/Copyright: June 21, 2022
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Hormone Molecular Biology and Clinical Investigation
From the journal Hormone Molecular Biology and Clinical Investigation Volume 43 Issue 4

Abstract

Many studies conducted after the pandemic period revealed that, while COVID-19 primarily injured the lungs, it also affects other organs in the form of cardiovascular complications, metabolic derangements, renal damage, and so on. Although we know that inflammatory cascades, complement activation, and pro-inflammatory cytokines are all involved in vasculitic processes that cause organ damage, we do not know the exact mechanism of complications such as acute respiratory distress syndrome (ARDS), cardiovascular ischemia, deep vein thrombosis, pulmonary thromboembolism, and brain injuries (embolism) that are frequently observed in COVID 19. The currently available biomarkers do not predict the severity of the aforementioned complications. As a result, more specific biomarkers such as serum calcium binding protein (S100B), glial fibrillary acid protein (GFAP), myelin basic protein (MBP), neuron-specific enolase (NSE), hs-TNI, (highly sensitive cardiac troponin) – HBDH, (Hydroxybutyrate Dehydrogenase), CK-MB (creatine kinase myocardial band), ST2 (suppression of tumorigenicity 2) are in need for early detection & improved clinical outcome.

Keywords: ARDS; brain specific markers; cardiac biomarkers; cardiac troponin; glial fibrillary acid protein; myelin basic protein; ST2
Corresponding author: Dr. Madhusudhan Umesh, MD, Department of Physiology, All India Institute of Medical Sciences, Bibinagar, Hyderabad, Telangana, 508126, India, E-mail:

Acknowledgments

We are thankful to Prof. Dr. Vikas Bhatia, Executive Director, All India Institute of Medical Sciences, Bibinagar, Telangana, 508126, India.

  1. Research funding: None.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interest: None to declare.

  4. Informed consent & Ethical approval: Not applicable.

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Received: 2022-01-27
Accepted: 2022-04-08
Published Online: 2022-06-21

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/hmbci-2022-0015
Keywords for this article
ARDS; brain specific markers; cardiac biomarkers; cardiac troponin; glial fibrillary acid protein; myelin basic protein; ST2

Articles in the same Issue

  1. Frontmatter
  2. Letter to the Editor
  3. COVID-19 pandemic: transmission of SARS-CoV-2 in animals, a risk for human beings
  4. Original Articles
  5. Anti Mullerian hormone as a diagnostic tool for polycystic ovary syndrome in women of reproductive age with morbid obesity
  6. Potential tumor marker for hepatocellular carcinoma identification: PI3K and pro-inflammatory cytokines (TGF-β, IL-1, and IL-6)
  7. The investigation of the frequency of the alpha-1-antitrypsin phenotype in patients with liver cirrhosis
  8. Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1α/SIRT3– independent GPx1 expression in the heart of mice with endometriosis
  9. Hypoxia-inducible factor-1α and ischemia-modified albumin levels in intensive care COVID-19 Patients
  10. Association between TP53 Arg72Pro variant and recurrent pregnancy loss in the Greek population
  11. Selective estrogen receptor α and β antagonist aggravate cardiovascular dysfunction in type 2 diabetic ovariectomized female rats
  12. Adrenocorticotropic hormone (ACTH) level and adrenal deficiency in patients with mucocutaneous pemphigus
  13. The effect of resistance training on serum levels of sex hormones and sperm quality in male rats under X-ray radiation
  14. The effect of high-intensity interval training on serum and adipose tissues vaspin levels in rats fed a high-fat high-sucrose diet
  15. Anti-migratory effect of curcumin on A-549 lung cancer cells via epigenetic reprogramming of RECK/ matrix metalloproteinase axis
  16. Efficacy of rectal progesterone on maternal and neonatal outcomes in pregnant women with Preterm Premature Rupture of membranes: a triple-blind randomised clinical trial
  17. Case Report
  18. Ovarian tissue cryopreservation in Malaysia: a case series
  19. Review Articles
  20. An overview of prognostic value of neurologic and cardiac biomarkers in patients with COVID-19 sequelae
  21. Potential role of melatonin in prevention and treatment of lung cancer
  22. Esketamine–A quick-acting novel antidepressant without the disadvantages of ketamine
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