Efficacy of rectal progesterone on maternal and neonatal outcomes in pregnant women with Preterm Premature Rupture of membranes: a triple-blind randomised clinical trial
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Shohre Vosoogh
Abstract
Objectives
This study was conducted to evaluate the efficacy of rectal progesterone suppositories on pregnancy outcomes of pregnant women diagnosed with PPROM at the gestational age of 26–34 weeks, as well as on maternal and neonatal outcomes.
Methods
This is a double-blind, randomized clinical trial in pregnant women with PROM with gestational age of 26–24 weeks, conducted between February 2020 and December 2020 in Sayyad Shirazi Hospital, Gorgan, Iran.
Results
According to the results of the present study; Rectal progesterone suppository in pregnant women with PPROM is associated with improved delivery outcomes such as neonatal APGAR score, increased latent delivery stage without complications or severe and dangerous complications, without increased risk of mortality and NICU hospitalization in infants, so prescribing suppository rectal progesterone in pregnant women with PPROM with a gestational age of 26 to 34 weeks is associated with positive outcomes and is recommended based on the findings and opinions of the researchers.
Conclusions
According to the results of the present study; Rectal progesterone suppository in pregnant women with PPROM is associated with improved delivery outcomes such as neonatal APGAR score, increased latent delivery stage without complications or severe and dangerous complications, without increased risk of mortality and NICU hospitalization in infants, so prescribing suppository rectal progesterone in pregnant women with PPROM with a gestational age of 26 to 34 weeks is associated with positive outcomes and is recommended based on the findings and opinions of the researchers.
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Research funding: None.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: No.
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Informed consent: Informed consent was obtained from all individuals
included in this study.
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Ethical approval: IRCT20200610047716N1.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
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Articles in the same Issue
- Frontmatter
- Letter to the Editor
- COVID-19 pandemic: transmission of SARS-CoV-2 in animals, a risk for human beings
- Original Articles
- Anti Mullerian hormone as a diagnostic tool for polycystic ovary syndrome in women of reproductive age with morbid obesity
- Potential tumor marker for hepatocellular carcinoma identification: PI3K and pro-inflammatory cytokines (TGF-β, IL-1, and IL-6)
- The investigation of the frequency of the alpha-1-antitrypsin phenotype in patients with liver cirrhosis
- Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1α/SIRT3– independent GPx1 expression in the heart of mice with endometriosis
- Hypoxia-inducible factor-1α and ischemia-modified albumin levels in intensive care COVID-19 Patients
- Association between TP53 Arg72Pro variant and recurrent pregnancy loss in the Greek population
- Selective estrogen receptor α and β antagonist aggravate cardiovascular dysfunction in type 2 diabetic ovariectomized female rats
- Adrenocorticotropic hormone (ACTH) level and adrenal deficiency in patients with mucocutaneous pemphigus
- The effect of resistance training on serum levels of sex hormones and sperm quality in male rats under X-ray radiation
- The effect of high-intensity interval training on serum and adipose tissues vaspin levels in rats fed a high-fat high-sucrose diet
- Anti-migratory effect of curcumin on A-549 lung cancer cells via epigenetic reprogramming of RECK/ matrix metalloproteinase axis
- Efficacy of rectal progesterone on maternal and neonatal outcomes in pregnant women with Preterm Premature Rupture of membranes: a triple-blind randomised clinical trial
- Case Report
- Ovarian tissue cryopreservation in Malaysia: a case series
- Review Articles
- An overview of prognostic value of neurologic and cardiac biomarkers in patients with COVID-19 sequelae
- Potential role of melatonin in prevention and treatment of lung cancer
- Esketamine–A quick-acting novel antidepressant without the disadvantages of ketamine
