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Haplotype-based association of regulator of G-protein signaling 5 gene polymorphisms with essential hypertension and metabolic parameters in Chinese
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Bing Xiao
Veröffentlicht/Copyright:
28. Oktober 2009
Abstract
Background: A recent genome-wide linkage study mapped blood pressure (BP)-related loci on human chromosome 1q and identified the regulator of G-protein signaling 5 (RGS5) as a candidate for regulation of BP. Thus, we assessed the relationship between RGS5 genetic polymorphisms and essential hypertension (EH) in Chinese.
Methods: A total of 906 patients with EH and 894 age- and gender-matched normotensive (NT) controls were enrolled. Sixteen single nucleotide polymorphisms (SNPs) in RGS5 were genotyped.
Results: There were no significant differences in the overall distributions of the genotypic and allelic frequencies for each SNPs between the two groups. However, in haplotype analysis, significant differences for the overall distributions were noted for four haplotypes constructed by five SNPs (rs12041294C/T, rs10917690A/G, rs10917695T/C, rs10917696T/C and rs2662774G/A), viz. H2 (C–A–C–T–A) (p=0.038), H5 (C–G–T–T–G) (p=0.001), H6 (T–G–C–T–A) (p=0.021) and H12 (T–A–T–T–G) (p=0.023). Serum concentrations of high- and low-density lipoprotein cholesterol showed significant associations with haplotypes revealed by a global test (p=0.0001 and 0.0309).
Conclusions: Multiple SNPs in combination in RGS5 may confer risk for hypertension. Our results also lend support for the effect of RGS5 SNPs on lipid metabolism. Further studies are warranted to find the causal SNPs in RGS5 for EH.
Clin Chem Lab Med 2009;47:1483–8.
Received: 2009-4-23
Accepted: 2009-9-3
Published Online: 2009-10-28
Published in Print: 2009-12-01
©2009 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Review
- Multiple gene interaction and modulation of hemostatic balance
- Minireview
- Appropriate utilization of clinical laboratory tests
- Genetics and Molecular Diagnostics
- Quantitation of RNA decay in dried blood spots during 20 years of storage
- ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study
- Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
- Haplotype-based association of regulator of G-protein signaling 5 gene polymorphisms with essential hypertension and metabolic parameters in Chinese
- A new automated human leukocyte antigen genotyping strategy to identify DR-DQ risk alleles for celiac disease and type 1 diabetes mellitus
- General Clinical Chemistry and Laboratory Medicine
- Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults
- Screening for M-proteinemia: serum protein electrophoresis and free light chains compared
- Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke
- Salivary neuron specific enolase: an indicator for neuronal damage in patients with ischemic stroke and stroke-prone patients
- Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis
- Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children
- Nucleated red blood cells and soluble transferrin receptor in thalassemia syndromes: relationship with global and ineffective erythropoiesis
- Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever
- Preanalytical mistakes in samples from primary care patients
- Should kidney tubular markers be adjusted for urine creatinine? The example of urinary cystatin C
- Validation and Outcome Studies
- Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP)
- Development and validation of a liquid chromatography-tandem mass spectrometry assay for serum 25-hydroxyvitamin D2/D3 using a turbulent flow online extraction technology
- Letters to the Editor
- Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population
- Falsely elevated troponin I attributed to collection tubes using the Vitros ECiQ system
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- Serum γ-glutamyltransferase: linking together environmental pollution, redox equilibria and progression of atherosclerosis?
- The impact factor for evaluating scientists: the good, the bad and the ugly
- Acknowledgement
- Acknowledgement
- Contents
- Contents, Volume 47, 2009
- Author Index
- Author Index
- Subject Index
- Subject Index
