Assessment of biochemical changes in normal and diabetic rats treated by phenolic enriched extracts of Juglans regia L. barks
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Nor-El-Houda Benahmed
,
Faiza Mouderas
Abstract
Objectives
Juglans regia L. is largely used by diabetic population, but its bark is scarcely investigated. The major aim of this study was to investigate the effect of the hydro-methanolic extract and fractions of J. regia L. barks on normoglycemic and diabetic rats through the evaluation of some biochemical parameters.
Methods
Phenolic enriched extracts were investigated for their effect on normoglycemic and diabetic rats through the determination of fasting blood glucose levels in short- and long-term. As well as plasma total cholesterol, triglycerides, insulin, urea, creatinine, alanine amino transferase (ALT) and aspartate amino transferase (AST) levels were measured after 28 days of treatment. Furthermore, the phytochemical composition was assessed by standard methods.
Results
Among the different extracts tested, the n-Butanol fraction presented the highest amounts of total phenolic, total flavonoids and flavonol contents (745 ± 0.6 mg GAE g−1, 162 ± 0.78 mg CE g−1 and 56.02 ± 0.92 mg QE g−1, respectively) and it found to be the most effective to decrease plasma total cholesterol, triglycerides and FGLs in treated diabetic rats in both short- and long-term treatment, mainly the dose 200 mg/kg after 28 days of treatment which found to be more effective than glibenclamide. This fraction also revealed pronounced improvement in liver and renal profiles.
Conclusions
J. regia L. barks had an important antidiabetic role similar to the reference glibenclamide. This may be related to the high contents of phenolic compounds.
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Research funding: None declared.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Competing interests: The authors declare that there is no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: The experiments were carried out under ethical conditions and were approved by the Ethical Committee for animals of Djilali Liabes University.
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Artikel in diesem Heft
- Frontmatter
- Reviews
- A preliminary systematic review and meta-analysis on the effects of heart rate variability biofeedback on heart rate variability and respiration of athletes
- The potential positive epigenetic effects of various mind-body therapies (MBTs): a narrative review
- The effect of Chlorella vulgaris on obesity related metabolic disorders: a systematic review of randomized controlled trials
- Biological and medicinal application of Cucumis sativus Linn. – review of current status with future possibilities
- The effect of the herbal medicine on severity of cyclic mastalgia: a systematic review and meta-analysis
- Research Articles
- Chemical compositions, antibacterial, antifungal and cytotoxic effects of Alhagi mannifera five extracts
- Anticonvulsive and anti-epileptogenesis effects of Echinacea purpurea root extract, an involvement of CB2 receptor
- Fermented maize slurry (Ogi) and its supernatant (Omidun) mitigate elevated intraocular pressure by modulating BDNF expression and glial plasticity in the retina-gut axis of glaucomatous rats
- Levetiracetam exposure during prenatal and postnatal period induces cognitive decline in rat offsprings, not completely prevented by Bacopa monnieri
- Antibiofilm action of Persea americana glycolic extract over Acinetobacter baumannii and absence of toxicity in Galleria mellonella
- Validation of Unani concept of Abadāl-i-Adwiya (drug substitution) by physicochemical standardization and hepatoprotective activity of Aristolochia rotunda Linn. and its substitute Curcuma Zedoaria Rosc. in albino Wistar rats
- Cinnamon oil as a co-chemotherapy agent through inhibition of cell migration and MMP-9 expression on 4T1 cells
- Assessment of biochemical changes in normal and diabetic rats treated by phenolic enriched extracts of Juglans regia L. barks
- Influence of Clerodendrum volubile leaf extract on doxorubicin-induced toxicity and inhibition of carbonyl reductase mediated metabolism
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- Evaluation of ethanol extracts from three species of Artocarpus as natural gastroprotective agents: in vivo and histopathological studies
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