Objectives As a core course in nursing education, “Fundamental Nursing” needs to align with the development trends of modern nursing education and cultivate patient-centered clinical decision-making abilities. Currently, there are problems in the teaching of intravenous therapy, such as insufficient understanding of its historical evolution, unclear technological evolution, and lack of integration of humanistic care. Taking the “Intravenous Therapy” chapter as an example, this paper constructs a “history-case-flipped” three-element integrated teaching model, aiming to improve students’ knowledge, skills, and professional values. Methods Based on Bloom’s Taxonomy of Educational Objectives, hierarchical goals are set across three dimensions: cognitive, affective, and psychomotor. The teaching content has been restructured into three major modules: historical evolution, core issues, and technological innovation, covering core knowledge points such as the development history of intravenous therapy, infection control, selection of infusion fluids, and speed control. A coupled model of flipped classroom and case-based learning are adopted. A progressive teaching process is designed: pre-class autonomous learning, in-class case discussion, and post-class reflection and practice. Multiple interactive forms, such as group discussions and scenario simulations, are combined to stimulate students’ learning initiative. Results Before class, digital resources (micro-lecture videos, literature) guide students in sorting out the technological development context. During class, evidence-based analysis and group collaboration focus on clinical cases, such as contraindications for lower limb venous puncture. After class, knowledge application is deepened through multi-media presentation and scientific research training. The evaluation system integrates process-based and formative assessments, including online tests, class participation, group work, and reflection reports, to comprehensively measure students’ overall competence. Conclusions This study constructs a “history-case-flipped” three-element integrated teaching model. It systematically optimizes the instructional design and implementation path of the “Intravenous Therapy” chapter in Basic Nursing Science . Teaching practice demonstrates that this model effectively integrates the historical context, core issues, and cutting-edge progress of intravenous therapy techniques. As a result, it significantly enhances students’ knowledge mastery, improves their clinical decision-making abilities, and fosters their professional values.