Synthesis of new eburnamine-type alkaloid via direct hydroalkoxylation
-
Xiong Liu
,
Dong-Liang Yang
Abstract
This study concerns the preparation of a new eburnamine-type alkaloid, methyl (3α,14β,15β,16α)-17,18-didehydro-14,15-dihydroeburnamine-15-methoxy-14-carboxylate (VIII). This alkaloid was prepared from (+)-17,18-dehydroapovincamine (V) using Lewis acid and/or ion exchange resin as catalyst. The hydroalkoxylation reaction of V with methanol was investigated in terms of catalyst, solvent, temperature, and time of reaction. A one-pot method for synthetising this alkaloid was established. The optimal conditions for the reaction are discussed.
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© 2013 Institute of Chemistry, Slovak Academy of Sciences
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Articles in the same Issue
- Rapid determination of fosetyl-aluminium in commercial pesticide formulations by high-performance liquid chromatography
- Immobilisation of acid pectinase on graphene oxide nanosheets
- Bench-scale biosynthesis of isonicotinic acid from 4-cyanopyridine by Pseudomonas putida
- Enzymatic synthesis of a chiral chalcogran intermediate
- Separation of Cd(II) and Ni(II) ions by supported liquid membrane using D2EHPA/M2EHPA as mobile carrier
- Fouling of nanofiltration membranes used for separation of fermented glycerol solutions
- Oxyhumolite influence on adsorption and desorption of phosphate on blast furnace slag in the process of two-stage selective adsorption of Cu(II) and phosphate
- Cellulose-precipitated calcium carbonate composites and their effect on paper properties
- Landfill leachate treatment using the sequencing batch biofilm reactor method integrated with the electro-Fenton process
- Effect of sintering temperature on the magnetic properties and charge density distribution of nano-NiO
- Synthesis, optimization, characterization, and potential agricultural application of polymer hydrogel composites based on cotton microfiber
- Cu(II) removal enhancement from aqueous solutions using ion-imprinted membrane technique
- Synthesis of new eburnamine-type alkaloid via direct hydroalkoxylation
- Selection of surfactants as main components of ecological wetting agent for effective extinguishing of forest and peat-bog fires
- Ultrasonic and Lewis acid ionic liquid catalytic system for Kabachnik-Fields reaction
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