Startseite In vivo evaluation of the antinociceptive effects of novel methylsulfonyl group-containing compounds
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In vivo evaluation of the antinociceptive effects of novel methylsulfonyl group-containing compounds

  • Hazal Eken ORCID logo EMAIL logo , Jale Akgöl ORCID logo , Berkant Kurban ORCID logo und Derya Osmaniye ORCID logo
Veröffentlicht/Copyright: 10. Februar 2025
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Abstract

Pain management is among the problems that remain important today, and analgesic agents such as nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, tricyclic antidepressants, and anticonvulsants used in pain treatment cause various side effects. Therefore, new, safe, and highly effective drugs are needed. Synthesis of chemical molecules has begun to be preferred as a faster and easier method in new drug development processes. In this study, new compounds (3a–3k) containing the “methylsulfonyl group,” which have been shown to have potential inhibitory effects on cyclooxygenase (COX) enzymes responsible for the synthesis of inflammatory mediators, were synthesized. Central antinociceptive effect of the compounds was evaluated by hot-plate and tail-immersion tests, and the peripheral antinociceptive effect was evaluated by acetic acid-induced writhing test. 3a, 3b, 3d, 3e, 3f, 3g, 3h, 3i, 3j, and 3k (20 mg/kg) significantly increased the percentage of the maximum possible effect (MPE %) in the hot-plate test compared to the control group. 3a–3k (20 mg/kg) significantly increased MPE % in the tail-immersion test compared to the control group and significantly decreased the number of writhings in the acetic acid-induced writhing test. The results of this study indicate that the synthesized compounds containing methylsulfonyl groups have central and peripheral antinociceptive effects.


Corresponding author: Hazal Eken, Department of Pharmacology, Faculty of Pharmacy, Afyonkarahisar Health Sciences University, 03030, Afyonkarahisar, Türkiye, E-mail:

Funding source: Afyonkarahisar Health Sciences University Scientific Research Projects Coordination Unit

Award Identifier / Grant number: 22.GENEL.006.

  1. Research ethics: The experimental protocols of this study have approved by the Local Ethical Committee on Animal Experimentation of Afyon Kocatepe University, Afyonkarahisar, Turkey (Decision No.: 49533702/59, 02/06/2022).

  2. Informed consent: Not applicable.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: The authors state no conflict of interest.

  6. Research funding: This study was supported by Afyonkarahisar Health Sciences University Scientific Research Projects Coordination Unit project number 22.GENEL.006.

  7. Data availability: The raw data can be obtained on request from the corresponding author.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/znc-2024-0210)


Received: 2024-09-27
Accepted: 2025-01-18
Published Online: 2025-02-10
Published in Print: 2025-09-25

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