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Phyto-pharmaceuticals as a safe and potential alternative in management of psoriasis: a review

  • Priya Patel , Kevinkumar Garala , Arti Bagada , Sudarshan Singh ORCID logo EMAIL logo , Bhupendra G. Prajapati ORCID logo EMAIL logo and Devesh Kapoor ORCID logo
Published/Copyright: November 12, 2024
Become an author with De Gruyter Brill

Abstract

Psoriasis is a chronic autoimmune skin disease with a worldwide prevalence of 1–3 % results from uncontrolled proliferation of keratinocytes and affects millions of people. While there are various treatment options available, some of them may come with potential side effects and limitations. Recent research has shown that using bioactive compounds that originate from natural sources with a lower risk of side effects are relatively useful in safe management psoriasis. Bioactive compounds are molecules that are naturally available with potential therapeutic efficacy. Some of bioactive compounds that have shown promising results in the management of psoriasis include curcumin, resveratrol, quercetin, epigallocatechin-3-gallate, etc., possess anti-inflammatory, antioxidant, immunomodulatory, and anti-proliferative properties, with capabilities to suppress overall pathogenesis of psoriasis. Moreover, these bioactive compounds are generally considered as safe and are well-tolerated, making them potential options for long-term use in the management of various conditions linked with psoriasis. In addition, these natural products may also offer a more holistic approach to treat the disease, which is appealing to many patients. This review explores the bioactive compounds in mitigation of psoriasis either in native or incorporated within novel drug delivery. Moreover, recent clinical findings in relation to natural product usage have been also explored.


Corresponding authors Sudarshan Singh, Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand; and Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand, E-mail: ; and Bhupendra G. Prajapati, Shree. S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, Gujarat 384012, India; and Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand, E-mail:

Abbreviations

DC

Dendritic cells

IL

Interleukin

Tregs

Regulatory T cells

IFN

Interferon

TNF-α

Tumor necrosis factor-α

APCs

Antigen-presenting cells

NADH

Nicotinamide adenine dinucleotide

PSE

Psoriatic skin equivalent

IMQ

Imiquimod

PASI

Psoriasis Area and Severity Index

Acknowledgments

This work was partially supported by CMU Proactive Researcher Scheme (2023), Chiang Mai University for Sudarshan Singh. Moreover, authors are grateful to Ganpat University for providing necessary facilities. In addition, Dr. Prajapati would like to extend his sincere appreciation to the Faculty of Pharmacy, Silpakorn University, Thailand, for their generous support that enabled the completion of this work.

  1. Research ethics: Not applicable.

  2. Informed consent: Third party material such as figures has been reproduced with permission from concern publication house.

  3. Author contributions: Conceptualization, SS and BGP; methodology, PP, KG, AB, and DUK; software, KG, AB, and DUK; validation, SS and BGP; investigation, KG, AB, and DUK; resources, SS; data curation, SS; writing original draft preparation, KG, AB, and DUK; writing review and editing, SS; visualization, BGP; supervision, BGP and SS; project administration, PP, SS, and BGP. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: All other authors state no conflict of interest.

  6. Research funding: None declared.

  7. Data availability: Data can be made available on request to corropondening authors.

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Received: 2024-07-15
Accepted: 2024-10-22
Published Online: 2024-11-12
Published in Print: 2025-09-25

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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