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Crystal structure of methyl 2-(4-(3-(2,4-difluorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)acetate, C21H15F2N3O2

  • Jiang Ping Meng , Bo Fang EMAIL logo and Hong Bo Tan EMAIL logo
Published/Copyright: May 3, 2019
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Zeitschrift für Kristallographie - New Crystal Structures
From the journal Zeitschrift für Kristallographie - New Crystal Structures Volume 234 Issue 4

Abstract

C21H15F2N3O2, triclinic, P1̄ (no. 2), a = 7.389(5) Å, b = 14.011(9) Å, c = 16.733(11) Å, α = 96.568(13)°, β = 100.432(13)°, γ = 94.589(13)°, V = 1683.6(19) Å3, Z = 4, Rgt(F) = 0.0589, wRref(F2) = 0.1621, T = 296 K.

CCDC no.: 1909488

The molecular structure is shown in the figure. Table 1 contains crystallographic data and Table 2 contains the list of the atoms including atomic coordinates and displacement parameters.

Table 1:

Data collection and handling.

Crystal:Yellow block
Size:0.28 × 0.22 × 0.17 mm
Wavelength:Mo Kα radiation (0.71073 Å)
μ:0.11 mm−1
Diffractometer, scan mode:Bruker APEX-II, φ and ω
θmax, completeness:25.0°, 99%
N(hkl)measured, N(hkl)unique, Rint:8606, 5888, 0.056
Criterion for Iobs, N(hkl)gt:Iobs > 2 σ(Iobs), 2400
N(param)refined:506
Programs:Bruker [1], SHELX [2], [3], Olex2 [4]
Table 2:

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2).

AtomxyzUiso*/Ueq
F10.3785(3)1.23461(16)0.27958(12)0.0726(8)
F20.1196(4)0.92217(17)0.27497(12)0.0816(9)
F30.5260(4)0.82840(18)0.20690(13)0.0966(10)
F40.2791(3)0.51462(16)0.20024(12)0.0724(8)
N10.0436(5)0.7917(2)0.47141(18)0.0625(11)
N20.1261(4)0.8461(2)0.54198(17)0.0475(9)
N30.2876(4)0.9985(2)0.59424(17)0.0504(9)
N40.1418(5)0.3914(2)0.39138(19)0.0571(10)
N50.2012(4)0.4497(2)0.46301(17)0.0462(9)
N60.3529(4)0.6029(2)0.51811(18)0.0514(9)
O1−0.0046(4)0.8398(2)1.06070(17)0.0721(9)
O20.2165(5)0.9593(3)1.08059(17)0.0898(12)
O30.2132(4)0.3565(2)1.04270(16)0.0680(9)
O40.4003(6)0.3456(3)0.9570(2)0.1278(17)
C10.3289(5)1.1615(3)0.3202(2)0.0504(11)
C20.2484(6)1.0766(3)0.2761(2)0.0562(12)
H20.2277521.0673240.2191330.067*
C30.1992(5)1.0052(3)0.3198(2)0.0515(11)
C40.2270(5)1.0134(3)0.4028(2)0.0449(10)
C50.3103(5)1.1027(3)0.4443(2)0.0522(11)
H50.3315371.1122750.5012810.063*
C60.3618(5)1.1768(3)0.4034(2)0.0560(12)
H60.4175301.2358700.4319160.067*
C70.1707(5)0.9359(3)0.4467(2)0.0460(11)
C80.0732(6)0.8479(3)0.4157(2)0.0601(13)
H80.0311380.8291900.3598090.072*
C90.2048(5)0.9335(3)0.5302(2)0.0425(10)
C100.2906(5)0.9726(3)0.6664(2)0.0533(12)
H100.3453971.0174930.7112920.064*
C110.2178(5)0.8820(3)0.6825(2)0.0425(10)
C120.1333(5)0.8194(3)0.6172(2)0.0468(10)
H120.0808380.7589010.6237610.056*
C130.2345(5)0.8595(3)0.7674(2)0.0464(10)
C140.1143(5)0.7904(3)0.7878(2)0.0539(11)
H140.0228050.7556460.7470100.065*
C150.1271(6)0.7718(3)0.8674(2)0.0585(12)
H150.0458180.7236640.8793490.070*
C160.2568(5)0.8227(3)0.9290(2)0.0495(11)
C170.3783(6)0.8901(3)0.9088(2)0.0586(12)
H170.4714250.9236720.9495800.070*
C180.3657(5)0.9096(3)0.8292(2)0.0518(11)
H180.4477130.9575100.8174660.062*
C190.2646(6)0.8058(3)1.0168(2)0.0690(14)
H19A0.2105920.7409241.0188980.083*
H19B0.3921250.8126681.0456840.083*
C200.1596(7)0.8779(4)1.0563(2)0.0595(13)
C21−0.1260(7)0.9039(4)1.0905(3)0.0925(17)
H21A−0.2421420.8682671.0911000.139*
H21B−0.0712200.9334061.1450670.139*
H21C−0.1461250.9531111.0552880.139*
C220.4648(6)0.7575(3)0.2472(2)0.0611(13)
C230.4019(6)0.6710(3)0.2024(2)0.0610(13)
H230.4005750.6598330.1464500.073*
C240.3405(5)0.6011(3)0.2444(2)0.0475(11)
C250.3409(5)0.6128(3)0.3267(2)0.0446(10)
C260.4076(6)0.7038(3)0.3673(2)0.0603(13)
H260.4108880.7157470.4234370.072*
C270.4693(6)0.7771(3)0.3281(2)0.0673(14)
H270.5125560.8380370.3563870.081*
C280.2760(5)0.5366(3)0.3696(2)0.0446(10)
C290.1876(5)0.4448(3)0.3368(2)0.0523(11)
H290.1631860.4231040.2808950.063*
C300.2837(5)0.5370(3)0.4522(2)0.0431(10)
C310.3351(5)0.5788(3)0.5891(2)0.0511(11)
H310.3845210.6237680.6347200.061*
C320.2490(5)0.4917(3)0.6038(2)0.0449(10)
C330.1826(5)0.4263(3)0.5375(2)0.0488(11)
H330.1253200.3663800.5428090.059*
C340.2288(5)0.4711(3)0.6869(2)0.0456(10)
C350.2677(6)0.5414(3)0.7534(2)0.0652(13)
H350.3150540.6030490.7472090.078*
C360.2379(7)0.5224(3)0.8292(2)0.0763(15)
H360.2684160.5710970.8734600.092*
C370.1659(6)0.4352(3)0.8406(2)0.0594(12)
C380.1294(6)0.3644(3)0.7757(3)0.0692(14)
H380.0836690.3027520.7826970.083*
C390.1590(6)0.3825(3)0.7000(2)0.0656(13)
H390.1305900.3328560.6563550.079*
C400.1233(7)0.4187(4)0.9219(2)0.0744(14)
H40A0.1098350.4805870.9515800.089*
H40B0.0051910.3796780.9131000.089*
C410.2628(7)0.3709(4)0.9737(3)0.0688(14)
C420.3301(6)0.3076(4)1.0975(2)0.0861(17)
H42A0.2779860.3018531.1454590.129*
H42B0.3412930.2444181.0710740.129*
H42C0.4500810.3434551.1129380.129*

Source of material

The solution of methyl 2-(4-(3-bromopyrazolo[1,5-a]pyrimidin-6-yl) phenyl)acetate (346.2 mg, 1 mmol), 2-(2,4-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (240.1 mg, 1 mmol), potassium carbonate (276.4 mg, 2 mmol) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (146.0 mg, 0.2 mmol) in dioxane (5 mL) and water (1 mL) was added in a 20 mL microwave vial, then degassed by nitrogen. The reaction solution was stirred at 25 °C for 1 h and heated under microwave irradiation at 120 °C for 0.5 h. The reaction mixture was washed with water and brine, and extracted with dichloromethane. The organic solution was dried over and concentrated. The crude product was purified by column chromatography over silica gel eluting with a gradient of methanol/dichloromethane (v/v, 0−3%) to afford the yellow solid. Yield, 284.6 mg, 74%. The title compound (100 mg, 0.26 mmol) was dissolved in dichloromethane, and the solvent was slowly evaporated at room temperature. After one week, light yellow crystals suitable for X-ray diffraction analysis were obtained.

Experimental details

Data reduction was carried out using the Bruker software APEX2 including SADABS [1]. The structure was determined by the intrinsic phasing routines in the SHELXT program [2] and refined by full-matrix least-squares methods in SHELXL [3] using Olex2 [4]. All of the H atoms were placed in the calculated positions and all the non-hydrogen atoms were refined anisotropically.

Comment

Heterocyclic building blocks represent useful scaffolds for applications in medicinal chemistry [5], catalytic chemistry, and materials chemistry [6]. Many pyrazole compounds have gotten extraordinary consideration for its organic and biological significance for instance as inhibitors of anticancer, pesticides, fungicides, and antihypertensive, also they are valuable starting materials for many heterocyclic systems [7], [8]. Pyrazolo[1,5-α]pyrimidine is an important aromatic fused heterocycle widely present in synthetic drugs and related intermediates [8].

In this work, we prepared methyl 2-(4-(3-(2,4-difluorophenyl)pyrazolo [1,5-a]pyrimidin-6-yl)phenyl)acetate in good yield using a coupling reaction of methyl 2-(4-(3-bromopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)acetate with 2-(2,4-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. This compound will be used for the development of novel AMPK inhibitors. One of two crystallographically independent molecules of the crystal structure is shown in the figure. The NMR results are consistent with the proposed structure. The asymmetric unit of the title compound contains two molecules. The bond lengths and angles in both crystallographically independent molecules are in the normal ranges [9]. In conclusion, we have developed a facile microwave-assisted process for the synthesis of the title compound using a one-pot procedure. This facile procedure can be readily used to synthesize a diverse range of compounds for high throughput screening in AMPK inhibitors.

Funding source: Science and Technology Research Program of Chongqing Municipal Education Commission

Award Identifier / Grant number: KJQN201801305 and KJQN201801321

Funding source: Natural Science Foundation Project of Yongchuan CSTC

Award Identifier / Grant number: YCSTC, 2016NC5001

Funding source: Chongqing University of Arts and Sciences

Award Identifier / Grant number: 2017RBX08 and P2017BX12

Funding statement: This work was supported by the Science and Technology Research Program of Chongqing Municipal Education Commission (Grant NO. KJQN201801305 and KJQN201801321), Natural Science Foundation Project of Yongchuan CSTC (YCSTC, 2016NC5001) and Chongqing University of Arts and Sciences (2017RBX08 and P2017BX12).

References

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2. Sheldrick, G. M.: SHELXT-integrated space-group and crystal structure determination. Acta Crystallogr. A71 (2015) 3–8.10.1107/S2053273314026370Search in Google Scholar PubMed PubMed Central

3. Sheldrick, G. M.: Crystal structure refinement with SHELXL. Acta Crystallogr. C71 (2015) 3–8.10.1107/S2053229614024218Search in Google Scholar PubMed PubMed Central

4. Dolomanov, O. V.; Bourhis, L. J.; Gildea, R. J.; Howard, J. A. K.; Puschmann, H.: OLEX2: A complete structure solution, refinement and analysis program. J. Appl. Crystallogr. 42 (2009) 339–341.10.1107/S0021889808042726Search in Google Scholar

5. Li, Y.; Meng, J. P.; Lei, J.; Chen, Z. Z.; Tang, D. Y.; Zhu, J.; Zhang, J.; Xu, Z. G.: Efficient synthesis of fused oxazepino-isoquinoline scaffolds via an Ugi, followed by an intramolecular cyclization. ACS Comb. Sci. 19 (2017) 324–330.10.1021/acscombsci.7b00002Search in Google Scholar PubMed

6. Tigreros, A.; Rosero, H.; Castillo, J.; Portilla, J.: Integrated pyrazolo[1,5-α]pyrimidine-hemicyanine system as a colorimetric and fluorometric chemosensor for cyanide recognition in water. Talanta 196 (2019) 395–401.10.1016/j.talanta.2018.12.100Search in Google Scholar PubMed

7. El Sayed, M. T.; Hussein, H. A. R.; Elebiary, N. M.; Hassan, G. S.; Elmessery, S. M.; Elsheakh, A. R.; Nayel, M.; Abdel-Aziz, H. A.: Tyrosine kinase inhibition effects of novel pyrazolo[1,5-α]pyrimidines and pyrido[2,3-δ]pyrimidines ligand: synthesis, biological screening and molecular modeling studies. Bioorg. Chem. 78 (2018) 312–323.10.1016/j.bioorg.2018.03.009Search in Google Scholar PubMed

8. Fang, B.; Meng, J. P.; Luo, Y.: Crystal structure of methyl 2-(4-(pyrazolo [1,5-α]pyrimidin-6-yl)phenyl)acetate, C15H13N3O2. Z. Kristallogr. NCS 234 (2019) 395–396.10.1515/ncrs-2018-0224Search in Google Scholar

9. Fang, B.; Meng, J. P.; Gan, L. L.: Crystal structure of methyl 2-(4-(3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-α]pyrimidin-6-yl)phenyl) acetate, C19H17N5O2. Z. Kristallogr. NCS 234 (2019) 575–577.10.1515/ncrs-2018-0580Search in Google Scholar

Received: 2019-02-18
Accepted: 2019-04-11
Published Online: 2019-05-03
Published in Print: 2019-06-26

© 2019 Jiang Ping Meng et al., published by De Gruyter, Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 Public License.

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  54. Crystal structure of 3-(5-amino-1H-1,2,4-triazol-3-yl)-1-(piperidin-1-yl)propan-1-one, C10H17N5O
  55. Crystal structure of aqua-2,2′,2′′-(((nitrilo-κN-tris(ethane-2,1-diyl))tris(azanylylidene-κ3N′,N′′,N′′′))tris(methanylylidene))tris(4-chlorophenolato-κ3O,O′,O′′)neodymium(III), C27H26Cl3N4NdO4
  56. Crystal structure of dichlorido-(μ2-2,2′-(diazene-1,2-diyl)bis(benzen-1-ido)-κ2C:C′)dimercury(II), C12H8Cl2Hg2N2
  57. Crystal structure of (3E,5E)-3,5-bis(4-cyanobenzylidene)-1-((4-fluorophenyl)sulfonyl)piperidin-4-one, C27H18FN3O3S
  58. Crystal structure of dichlorido(pyridine-κN)(2,4,6-tri-2-pyridyl-1,3,5-triazine-κ3N2,N1,N6)nickel(II), C23H17Cl2N7Ni
  59. Redetermination of the crystal structure of tetrakis(4-chlorobenzyl)tin(IV), C28H24Cl4Sn
  60. The crystal structure of 2,6-bis(pyridin-1-ium-3-ylmethyl)hexahydro-4,8-ethenopyrrolo-[3,4-f] isoindole-1,3,5,7-tetrone tetrachloridocuprate(II) monohydrate, C24H24Cl4CuN4O5
  61. Crystal structure of cyclo-[octaaqua-tetrakis(μ2-5,5′-(1H-imidazole-4,5-diyl)bis(tetrazol-2-ido)-κ4N,N′,N′′,N′′′)tetramagnesium(II)], C20H24N40O8Mg4
  62. The crystal structure of a matrine derivative, 13-(4-Cl-pyrrole)-matrine, C18H26ClN4O
  63. Crystal structure of (dibenzyl sulphoxide-κO)bis(2-chlorobenzyl-κC1)dichloridotin(IV), C28H26Cl4OSSn
  64. Crystal structure of catena-poly[(μ2-azido-κ2N:N)(μ2-4-cyanobenzoato-κ2O:O′)-(μ2-methanol-κ2O:O)copper(II)], C9H8CuN4O3
  65. Crystal structure of 1,1′-dibenzyl-3,3′-dicyano-1,1′,4,4′-tetrahydro-4,4′-bipyridine, C26H22N4
  66. Crystal structure of (2-bromobenzyl)((1-bromonaphthalen-2-yl)methyl)sulfane, C18H14Br2S
  67. Crystal structure of 2-(4-ammoniocyclohexyl)-3-(pyridin-2-yl)imidazo[1,5-a]pyridin-2-ium 2-[(2-carboxylatophenyl)disulfanyl]benzoate dihydrate, [C18H22N4][C14H8O4S2] ⋅ 2H2O
  68. Crystal structure of (E)-N-((3R,5S,10S, 13S,14S,17S)-17-((S)-1-(dimethylamino)ethyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-2-methylbut-2-enamide – water – methanol (1/1/1), C29H54N2O3
  69. Crystal structure of methyl 2-(4-(3-(2,4-difluorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)acetate, C21H15F2N3O2
  70. Crystal structure of poly[triaqua-(μ4-benzene-1,3,5-tricarboxylato-κ5O1,O2:O3:O4:O5)-(μ2-5-(3-pyridyl)tetrazolato-κ2N1:N3)dizinc(II)], C15H13N5O9Zn2
  71. Crystal structure of N-(3-methylphenyl)(propan-2-yloxy)carbothioamide, C11H15NOS
  72. Crystal structure of poly[(μ2-1,3-bis(imidazol-1-ylmethyl)benzene-κ2N:N′)(nitrato-κ1O)cadmium(II)] — water (2/1), C28H32CdN10O7
  73. Crystal structure of 4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione, C8H7N3S
  74. Crystal structure of benzyltrichloridobis(1H-pyrazole-κ2N)tin(IV), C13H15Cl3N4Sn
  75. Crystal structure of chlorido-4-fluorobenzyl-bis(2-methylquinolin-8-olato-κ2N,O)tin(IV), C27H22ClFN2O2Sn
  76. Crystal structure of tetrakis(O,O′-diisopropyldithiophosphato-κ2S,S′)-(μ2-1,2-bis(4-pyridylmethylene)hydrazine-κ2N:N′)zinc(II), C36H66N4O8P4S8Zn2
  77. Crystal structure of tetrabutylammonium 4,4-oxydibenzoate – boric acid – water (1/2/6) C46H98B2N2O17
  78. Redetermination of the crystal structure of catena-poly[[tribenzyltin(IV)]-(μ2-pyridine-4-carboxylato-κ2N:O)], C27H25NO2Sn
  79. The synthysis and crystal structure of cyclohexyl 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-1H-pyrazole-3-carboxylate, C18H15N3Cl2F6O3S
  80. The crystal structure of 5,7-bis(2-hydroxyethoxy)-2-phenyl-4H-chromen-4-one, C19H18O6
  81. Synthesis and crystal structure of (±)-Ethyl 5′-(difluoromethyl)-2-oxo-4′,5′-dihydrospiro[indoline-3,3′-pyrazole]-4′-carboxylate, C14H13F2N3O3
https://doi.org/10.1515/ncrs-2019-0123
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Articles in the same Issue

  1. Frontmatter
  2. Crystal structure of (E)-2-(1-((2-aminophenyl)imino)ethyl)-5-fluorophenol, C14H13FN2O
  3. Crystal structure of (E)-2-(1-((2-aminophenyl)imino)ethyl)-4,6-dichlorophenol, C14H12Cl2N2O
  4. The crystal structure of (E)-1-(4-methoxyphenyl)-3-(2-nitrophenyl)triaz-1-ene C8H8N2O4
  5. Crystal structure of (E)-2-(((6-bromopyridin-2-yl)methylene)amino)-3′,6′-bis(ethylamino)-2′,7′-dimethylspiro[isoindoline-1,9′-xanthen]-3-one—methanol (1:1), C32H30N5O2Br ⋅ CH4O
  6. Crystal structure of 2,4-pentanedione bis(2,4-dinitrophenylhydrazone), C17H16N8O8
  7. Crystal structure of sodium morpholine-4-carbodithioate, (C5H12NNaO3S2)
  8. Crystal structure of 1,1′-(hexane-1,6-diyl)bis(3-ethyl-1H-imidazol-3-ium) bis(hexafluorido phosphate), C16H28F12N4P2
  9. Crystal structure of 5-(4-chlorophenyl)-3-(4-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole, C21H16ClFN2
  10. Crystal structure of catena-poly[diaqua-bis(3-carboxy-5-methoxybenzoato-κO)-(1,2-bis(imidazol-1-yl)ethane-κ2N:N′)cobalt(II)], C26H28CoN4O12, [Co(C9H6O5)2(H2O)2(C8H10N4)]
  11. The crystal structure of 3-cyclohexyl-1,5-dioxaspiro[5.5]undecane-2,4-dione, C15H22O4
  12. Crystal structure of (2,4-dimethoxybenzyl)triphenylphosphonium trifluoroacetate — trifluoroacetic acid (1/1), C31H27F6O6P
  13. Crystal structure of 4-tert-butyl-1-(2,6-dimethylphenyl)-1H-1,2,3-triazole, C14H19N3
  14. Crystal structure of 1,1′-methylenebis(4-tert-butylpyridinium) tetrachloridocobaltate(II) – dichloromethane (1:1), C20H30Cl6CoN2
  15. Crystal structure of (4,4′-(ethane-1,2-diylbis((nitrilo)(2-furylmethylylidene)))bis(3-methyl-1-phenyl-1H-pyrazol-5-olato-κ4N,N′,O,O′))-nickel(II)), C32H26N6NiO4
  16. Synthesis and crystal structure of bis{((E)-((4-((E)-1-(benzyloxyimino)ethyl)phenyl)imino)methyl)-2-phenolato-κ2N,O}copper(II), C44H38CuN4O4
  17. Crystal structure of catena-poly[diaqua-bis(3,5-dichloropyridine-4-carboxylato-κ1O)-bis(μ2-4,4′-bipyridine-κ2N:N′)cobalt(II)], C22H16Cl4CoN4O6
  18. The crystal structure of 2-(4-chloro-2,6-dinitrophenyl)-1-(4-chloro-3,5-dinitrophenyl)diazene 1-oxide, C12H4Cl2N6O9
  19. The crystal structure of 3-(1H-benzo[d]imidazol-2-yl)-7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydroquinolin — dimethylsulfoxide (1/1), C21H19ClFN3O2S
  20. The crystal structure of dichlorido-bis(1-butyl-1H-imidazole-κN)zinc(II), C14H24Cl2ZnN4
  21. (Z)-N-tert-butyl-1-(2-(3,5-dichlorobenzamido)phenyl) methanimine oxide, C18H18Cl2N2O2
  22. Crystal structure of diaqua-bis(3-carboxy-5-bromoisophthalato-κO)-bis(1-(3-(1H-benzo[d]imidazol-1-yl)propyl)-1H-benzo[d]imidazol-3-ium-κN)nickel(II) bis(3-carboxy-5-bromoisophthalate), C66H54Br4N8NiO18
  23. Crystal structure of poly[aqua(μ2-5-methoxyisophthalato-κ2O,O′:O′′)-(1,2-bis(imidazol-1′-yl)ethane-κ2N:N′)cobalt(II), C34H36Co2N8O12
  24. Crystal structure of poly[diaqua-bis(μ2-1-(4-(1H-imidazol-1-yl)benzyl)-1H-1,2,4-triazole-κ2N:N′)manganese(II)] terephthalate tetrahydrate, MnC32H38N10O10
  25. Crystal structure of the fluorescent fipronil derivative 5,5′-(methylenebis(azanediyl))bis(1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-1H-pyrazole-3-carbonitrile), C25H6N8O2Cl4F12S2
  26. Crystal structure of the phosphorescent complex diethyldithiophosphonato-κ2S,S′-bis(2-phenylpyridinato-κ2C,N)iridium(III), C26H26N2O2PS2Ir
  27. The crystal structure of 4,10-diethoxy-6H,12H-6,12-epoxydibenzo[b,f][1,5]dioxocine, C18H18O5
  28. Crystal structure of dichlorido-bis(N-benzyl-2-(quinolin-8-yloxy)acetamide-κ2N,O)copper(II) — ethyl acetate (1/1), C38H36N4O6Cl2Cu
  29. Synthesis and crystal structure of bis{4-methyl-2-((E)-((4-((E)-1-(benzyloxyimino)ethyl)phenyl)imino)methyl)phenolato-κ3N,O,O}copper(II), C92H84Cu2N8O8
  30. The crystal structure of 1,3,5-trinitro-4,6-diazidobenzene, C6HN9O6
  31. Crystal structure 1-cinnamyl-2-((Z)-styryl)-1H-benzo[d]imidazole — methanol (1/1), C24H20N2 ⋅ CH4O
  32. The crystal structure of poly[m2-aqua-tetraaqua-bis(m9-4-formylbenzene-1,3-disulfonato)tetrasodium(I) hydrate, C14H18O19S4Na4
  33. Crystal structure of 2-((2,8-bis(trifluoromethyl)quinolin-4-yl)(hydroxy)methyl)piperidin-1-ium trifluoroacetate, [C17H17F6N2O][C2F3O2]
  34. The crystal structure of bis(ferrocenecarboxylato-κ2O,O′)bis[4-(dimethylamino)pyridine-κN]copper(II) — acetonitrile(1/2), C40H44CuO4Fe2N6
  35. Crystal structure of poly[di-μ2-aqua)-diaqua-bis(μ6-4,4′,4′′-(benzene-1,3,5-triyltris(oxy))tribenzoato-κ6O1:O2:O3:O3:O5:O6)tricadmium(II)] dihydrate, C54H42Cd3O24
  36. The crystal structure of dichlorido(1,3-bis(2,6-diisopropyl-phenyl)-1H-3λ4-imidazol-2-yl)(3-phenyl-pyridine-κN)palladium(IV), C38H45N3Cl2Pd
  37. The crystal structure of 2-chloro-4-(prop-2-yn-1-yloxy)-6-phenyl-1,3,5-triazine, C12H8ClN3O
  38. The crystal structure of 2,6-di-tert-butyl-4-(phenyl(phenylsulfonyl)methyl)phenol, C27H32O3S
  39. Crystal structure of bis{μ2-bis{(((((1-methoxyimino)ethyl)phenyl)imino)methyl)-2-phenolato-κ3N,O:O}copper(II)}, C68H68Cu2N8O8
  40. Crystal structure of catena-poly[tetraaqua-bis(μ2-2-(4-carboxylatophenoxy)benzoato-κ2O:O′)-pentakis(pyridine-κ1N)dinickel(II)], C53H47N5Ni2O13
  41. Synthesis and crystal structure of 1-(2,6-dichloro-4-trifluoromethyl-phenyl)-5-(3-methoxy-benzylamino)-4-trifluoromethanesulfinyl-1H-pyrazole-3-carbonitrile, C20H12N4Cl2F6O2S
  42. Redetermination of the crystal structure of bis(μ2-di-ethyldithiocarbamato-κ3S,S′:S;κ3S:S: S′)-hexacarbonyl-di-rhenium(I), C16H20N2O6Re2S4
  43. The crystal structure of (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)-2-phenylacetohydrazide, C19H16O2N2
  44. Crystal structure of 6-hydroxy-4,8,11b-trimethyltetradecayhdro-8,11-epoxy-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid – methanol (1/1), C20H30O4
  45. The crystal structure of aqua-bis(3-acetyl-2-oxo-2H-chromen-4-olato-κ2O,O′)zinc(II) monohydrate, C22H18O10Zn
  46. Crystal structure of poly[bis(μ2-4-bromoisophthalate-κ2O:O′)-tris(μ2-1-(3-((1H-1,2,4-triazol-1-yl)methyl)benzyl)-1H-1,2,4-triazole-κ2N:N′)dicobalt(II)] monohydrate, C26H23CoN9O5Br
  47. A cyclic I102− anion in the layered crystal structure of theophyllinium pentaiodide, C7H9I5N4O2
  48. Crystal structure of catena-poly[diaqua-bis(μ2-4-((4-(pyridin-2-ylmethoxy)phenyl)diazenyl)benzoato-κ3O,O′:N)cadmium(III)], Cd(C19H14O3N3)2(H2O)
  49. Crystal structure of catena-poly[(μ2-4,4′-bipyridyl-κN,N′)-bis(O,O′-dimethyldithiophosphato-κS)-zinc(II)], {C14H20N2O4P2S4Zn}n
  50. Crystal structure of 3-amino-2-hydroxy-6-methoxybenzamide hydrate, C16H22N4O7
  51. Crystal structure of hemikis(cyclohexane-1,4-diammonium) (pyridine-2-carboxylate), [C6H16N2]0.5[C6H4NO2]
  52. Crystal structure of 2-chloro-4-(prop-2-yn-1-yloxy)-6-(thiophen-2-yl)-1,3,5-triazine, C10H6ClN3OS
  53. The crystal structure of 3-butyl-1-methyl-1H-imidazol-3-ium catena-poly[tris(μ2-bromido-κ2Br:Br)lead(II)], C8H15Br3N2Pb
  54. Crystal structure of 3-(5-amino-1H-1,2,4-triazol-3-yl)-1-(piperidin-1-yl)propan-1-one, C10H17N5O
  55. Crystal structure of aqua-2,2′,2′′-(((nitrilo-κN-tris(ethane-2,1-diyl))tris(azanylylidene-κ3N′,N′′,N′′′))tris(methanylylidene))tris(4-chlorophenolato-κ3O,O′,O′′)neodymium(III), C27H26Cl3N4NdO4
  56. Crystal structure of dichlorido-(μ2-2,2′-(diazene-1,2-diyl)bis(benzen-1-ido)-κ2C:C′)dimercury(II), C12H8Cl2Hg2N2
  57. Crystal structure of (3E,5E)-3,5-bis(4-cyanobenzylidene)-1-((4-fluorophenyl)sulfonyl)piperidin-4-one, C27H18FN3O3S
  58. Crystal structure of dichlorido(pyridine-κN)(2,4,6-tri-2-pyridyl-1,3,5-triazine-κ3N2,N1,N6)nickel(II), C23H17Cl2N7Ni
  59. Redetermination of the crystal structure of tetrakis(4-chlorobenzyl)tin(IV), C28H24Cl4Sn
  60. The crystal structure of 2,6-bis(pyridin-1-ium-3-ylmethyl)hexahydro-4,8-ethenopyrrolo-[3,4-f] isoindole-1,3,5,7-tetrone tetrachloridocuprate(II) monohydrate, C24H24Cl4CuN4O5
  61. Crystal structure of cyclo-[octaaqua-tetrakis(μ2-5,5′-(1H-imidazole-4,5-diyl)bis(tetrazol-2-ido)-κ4N,N′,N′′,N′′′)tetramagnesium(II)], C20H24N40O8Mg4
  62. The crystal structure of a matrine derivative, 13-(4-Cl-pyrrole)-matrine, C18H26ClN4O
  63. Crystal structure of (dibenzyl sulphoxide-κO)bis(2-chlorobenzyl-κC1)dichloridotin(IV), C28H26Cl4OSSn
  64. Crystal structure of catena-poly[(μ2-azido-κ2N:N)(μ2-4-cyanobenzoato-κ2O:O′)-(μ2-methanol-κ2O:O)copper(II)], C9H8CuN4O3
  65. Crystal structure of 1,1′-dibenzyl-3,3′-dicyano-1,1′,4,4′-tetrahydro-4,4′-bipyridine, C26H22N4
  66. Crystal structure of (2-bromobenzyl)((1-bromonaphthalen-2-yl)methyl)sulfane, C18H14Br2S
  67. Crystal structure of 2-(4-ammoniocyclohexyl)-3-(pyridin-2-yl)imidazo[1,5-a]pyridin-2-ium 2-[(2-carboxylatophenyl)disulfanyl]benzoate dihydrate, [C18H22N4][C14H8O4S2] ⋅ 2H2O
  68. Crystal structure of (E)-N-((3R,5S,10S, 13S,14S,17S)-17-((S)-1-(dimethylamino)ethyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-2-methylbut-2-enamide – water – methanol (1/1/1), C29H54N2O3
  69. Crystal structure of methyl 2-(4-(3-(2,4-difluorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)acetate, C21H15F2N3O2
  70. Crystal structure of poly[triaqua-(μ4-benzene-1,3,5-tricarboxylato-κ5O1,O2:O3:O4:O5)-(μ2-5-(3-pyridyl)tetrazolato-κ2N1:N3)dizinc(II)], C15H13N5O9Zn2
  71. Crystal structure of N-(3-methylphenyl)(propan-2-yloxy)carbothioamide, C11H15NOS
  72. Crystal structure of poly[(μ2-1,3-bis(imidazol-1-ylmethyl)benzene-κ2N:N′)(nitrato-κ1O)cadmium(II)] — water (2/1), C28H32CdN10O7
  73. Crystal structure of 4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione, C8H7N3S
  74. Crystal structure of benzyltrichloridobis(1H-pyrazole-κ2N)tin(IV), C13H15Cl3N4Sn
  75. Crystal structure of chlorido-4-fluorobenzyl-bis(2-methylquinolin-8-olato-κ2N,O)tin(IV), C27H22ClFN2O2Sn
  76. Crystal structure of tetrakis(O,O′-diisopropyldithiophosphato-κ2S,S′)-(μ2-1,2-bis(4-pyridylmethylene)hydrazine-κ2N:N′)zinc(II), C36H66N4O8P4S8Zn2
  77. Crystal structure of tetrabutylammonium 4,4-oxydibenzoate – boric acid – water (1/2/6) C46H98B2N2O17
  78. Redetermination of the crystal structure of catena-poly[[tribenzyltin(IV)]-(μ2-pyridine-4-carboxylato-κ2N:O)], C27H25NO2Sn
  79. The synthysis and crystal structure of cyclohexyl 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-1H-pyrazole-3-carboxylate, C18H15N3Cl2F6O3S
  80. The crystal structure of 5,7-bis(2-hydroxyethoxy)-2-phenyl-4H-chromen-4-one, C19H18O6
  81. Synthesis and crystal structure of (±)-Ethyl 5′-(difluoromethyl)-2-oxo-4′,5′-dihydrospiro[indoline-3,3′-pyrazole]-4′-carboxylate, C14H13F2N3O3
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