Racial and ethnic representation in 17-hydroxyprogesterone caproate preterm birth prevention studies: a systematic review
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Megan M. Smith
Abstract
Objectives
The US preterm birth rate varies dramatically by race and ethnicity yet the racial and ethnic representation within studies evaluating 17-hydroxprogesterone caproate (17-P) for preterm birth prevention is unknown. The objectives of our study were to 1) examine the racial and ethnic representation of participants in 17-P preterm birth prevention studies, 2) evaluate adherence to the NIH race and ethnicity reporting guidelines and 3) compare racial and ethnic representation in research studies to national preterm birth incidence.
Methods
We systematically reviewed US studies published between January 2000 and December 2019. Study participant’s race and ethnicity were reported using descriptive statistics then compared to US 2017//2018 preterm birth data using Pearson’s chi-square.
Results
Eighteen studies met the inclusion criteria, 17 studies reported race, 11 studies reported ethnicity, and yet none of the studies followed the NIH criteria. Compared to 2017/2018 US preterm births, the proportion of black/African American study participants was significantly higher whereas the proportions of all other race categories were lower.
Conclusions
More detailed reporting of race and ethnicity is needed in 17-P literature. Black women appear to be well represented while other racial and ethnic groups may be understudied.
Funding source: The National Center for Advancing Translational Sciences of the National Institutes of Health
Award Identifier / Grant number: 1KL2TR002554
Funding source: National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research
Award Identifier / Grant number: UL1TR002553
Acknowledgments
The Duke BERD Method Core’s support of this project was made possible (in part) by Grant Number UL1TR002553 from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NCATS or NIH.
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Research funding: Dr. Wheeler is supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number 1KL2TR002554. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: The local Institutional Review Board deemed the study exempt (Pro00100909) prior to initiation.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review
- Neonatal and child mortality – are they different in developing and developed countries?
- WAPM Guideline
- First trimester examination of fetal anatomy: clinical practice guideline by the World Association of Perinatal Medicine (WAPM) and the Perinatal Medicine Foundation (PMF)
- Original Articles – Obstetrics
- Symptoms of maternal psychological distress during pregnancy: sex-specific effects for neonatal morbidity
- Efficacy of the lactate dehydrogenase (LDH)/lymphocyte ratio (LLR) to reduce the need for X-ray in pregnant patients with COVID-19
- Attitude of pregnant and lactating women toward COVID-19 vaccination in Jordan: a cross-sectional study
- Association between maternal thyroid function and risk of gestational hypertension and preeclampsia
- Evaluation of umbilical cord immune cells in pregnancies with autoimmune disorders and/or methylenetetrahydrofolate reductase polymorphisms
- The association between induction of labour in nulliparous women at term and subsequent spontaneous preterm birth: a retrospective cohort study
- Transvaginally surgically treatment of early postpartum hemorrhage caused by lower uterine segment atony
- Value of soluble fms-like tyrosine kinase-1/placental growth factor test in third trimester of pregnancy for predicting preeclampsia in asymptomatic women
- Fetal growth regulation via insulin-like growth factor axis in normal and diabetic pregnancy
- Intrapartum cardiotocography in pregnancies with and without fetal CHD
- Racial and ethnic representation in 17-hydroxyprogesterone caproate preterm birth prevention studies: a systematic review
- Original Articles – Fetus
- Improved method for revising the Israel birthweight references
- A single center experience in 90 cases with nonimmune hydrops fetalis: diagnostic categories ‒ mostly aneuploidy and still often idiopathic
- Original Articles – Neonates
- Diagnosis of congenital infections in premature, low-birthweight newborns with intrauterine growth restriction caused by cytomegalovirus (CMV), herpes simplex virus (HSV), Parvo-B 19, and Zika virus: a systematic review
- The impact of COVID-19 on smoking cessation in pregnancy
- Letter to the Editor
- Early placenta previa percreta and treatment with supracervical abortion hysterectomy
Artikel in diesem Heft
- Frontmatter
- Review
- Neonatal and child mortality – are they different in developing and developed countries?
- WAPM Guideline
- First trimester examination of fetal anatomy: clinical practice guideline by the World Association of Perinatal Medicine (WAPM) and the Perinatal Medicine Foundation (PMF)
- Original Articles – Obstetrics
- Symptoms of maternal psychological distress during pregnancy: sex-specific effects for neonatal morbidity
- Efficacy of the lactate dehydrogenase (LDH)/lymphocyte ratio (LLR) to reduce the need for X-ray in pregnant patients with COVID-19
- Attitude of pregnant and lactating women toward COVID-19 vaccination in Jordan: a cross-sectional study
- Association between maternal thyroid function and risk of gestational hypertension and preeclampsia
- Evaluation of umbilical cord immune cells in pregnancies with autoimmune disorders and/or methylenetetrahydrofolate reductase polymorphisms
- The association between induction of labour in nulliparous women at term and subsequent spontaneous preterm birth: a retrospective cohort study
- Transvaginally surgically treatment of early postpartum hemorrhage caused by lower uterine segment atony
- Value of soluble fms-like tyrosine kinase-1/placental growth factor test in third trimester of pregnancy for predicting preeclampsia in asymptomatic women
- Fetal growth regulation via insulin-like growth factor axis in normal and diabetic pregnancy
- Intrapartum cardiotocography in pregnancies with and without fetal CHD
- Racial and ethnic representation in 17-hydroxyprogesterone caproate preterm birth prevention studies: a systematic review
- Original Articles – Fetus
- Improved method for revising the Israel birthweight references
- A single center experience in 90 cases with nonimmune hydrops fetalis: diagnostic categories ‒ mostly aneuploidy and still often idiopathic
- Original Articles – Neonates
- Diagnosis of congenital infections in premature, low-birthweight newborns with intrauterine growth restriction caused by cytomegalovirus (CMV), herpes simplex virus (HSV), Parvo-B 19, and Zika virus: a systematic review
- The impact of COVID-19 on smoking cessation in pregnancy
- Letter to the Editor
- Early placenta previa percreta and treatment with supracervical abortion hysterectomy
