Diagnosis of congenital infections in premature, low-birthweight newborns with intrauterine growth restriction caused by cytomegalovirus (CMV), herpes simplex virus (HSV), Parvo-B 19, and Zika virus: a systematic review

Janaina F. Lino; Lilian M. O. Diniz; Larissa G. Rezende; Victoria F. T. Costa; Roberta M. C. Romanelli

doi:10.1515/jpm-2021-0244

Article

Diagnosis of congenital infections in premature, low-birthweight newborns with intrauterine growth restriction caused by cytomegalovirus (CMV), herpes simplex virus (HSV), Parvo-B 19, and Zika virus: a systematic review

Janaina F. Lino , Lilian M. O. Diniz , Larissa G. Rezende , Victoria F. T. Costa and Roberta M. C. Romanelli

Published/Copyright: April 18, 2022

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From the journal Journal of Perinatal Medicine Volume 50 Issue 7

Abstract

Objectives

To identify the prevalence of viral congenital infections in newborns classified as premature, low-birthweight, small for gestational age or intrauterine growth restriction.

Methods

The definition considered for selecting papers were: P as newborns younger than 28 days; V as low-birthweight, prematurity and intrauterine growth restriction; O as frequency of congenital infections with Cytomegalovirus, Parvovirus B19, Herpes Simplex, and Zika virus. The research was performed using EMBASE, LILACS, SCOPUS and MEDLINE databases, with no limitations on date and language.

Results

Eight studies were included. Manuscripts including Herpes Simplex, Zika virus or Parvovirus B19 did not fulfill the defined criteria. A wide variation in the frequency of CMV congenital infection (0–4.8%) was found, which might be attributed to regional and methodological differences between investigations.

Conclusions

Newborn characteristics associated with CMV congenital infections may direct investigations towards these patients with a higher probability of infection. However, as data are controversial, studies concerning screening of infection are important to define recommendations of diagnosis.

Keywords: congenital infection; fetal growth retardation; infant, premature; infant, small for gestational age; infant, very low birth weight; infectious disease transmission, vertical

Corresponding author: Roberta Romanelli, MD, PhD, Professor, Pediatrics Department of Federal University of Minas Gerais School Medicine, 190 Professor Alfredo Balena Drive, Belo Horizonte, Minas Gerais, Brazil – 30130-100, Phone: +55 31 3409-9773/3409-9772, E-mail: pedfm@medicina.ufmg.br, rmcromanelli@gmail.com

Funding source: Conselho Nacional de Desenvolvimento Científico e Tecnológico

Research funding: The Institutional Scientific Initiation Scholarship Program was supported by the Federal University of Minas Gerais/Conselho Nacional de Desenvolvimento Científico e Tecnológico (PIBIC/CNPq), Brazil.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: The authors have no conflicts of interest to declare.
Informed consent: Not applicable.
Ethical approval: The local Institutional Review Board deemed the study exempt from review.

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Received: 2021-05-12

Accepted: 2022-02-28

Published Online: 2022-04-18

Published in Print: 2022-09-27

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Articles in the same Issue

https://doi.org/10.1515/jpm-2021-0244

Keywords for this article

congenital infection; fetal growth retardation; infant, premature; infant, small for gestational age; infant, very low birth weight; infectious disease transmission, vertical