Startseite Adverse perinatal outcomes following the prenatal diagnosis of isolated single umbilical artery in singleton pregnancies: a systematic review and meta-analysis
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Adverse perinatal outcomes following the prenatal diagnosis of isolated single umbilical artery in singleton pregnancies: a systematic review and meta-analysis

  • Themistoklis Dagklis , Antonios Siargkas , Aikaterini Apostolopoulou , Ioannis Tsakiridis ORCID logo , Apostolos Mamopoulos , Apostolos Athanasiadis und Alexandros Sotiriadis ORCID logo EMAIL logo
Veröffentlicht/Copyright: 7. Dezember 2021
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 50 Heft 3

Abstract

Objectives

A systematic review and meta-analysis was conducted to quantitatively synthesize the current evidence on the association of prenatally diagnosed isolated single umbilical artery (iSUA) in singleton pregnancies with small for gestational age (SGA) neonates and other perinatal outcomes.

Methods

A search of PubMed/Medline, Scopus and The Cochrane Library was conducted, from inception to February 2021, in order to identify studies comparing the risk of SGA and other perinatal adverse outcomes in prenatally diagnosed iSUA singleton pregnancies vs. those with a 3-vessel cord (3VC). The quality of eligible studies was assessed according to the improved Newcastle–Ottawa Scale (NOS). The heterogeneity of results across the studies was tested using the I2 test. Funnel plots and Egger’s test were used to assess the possibility of publication bias. Prospero RN: CRD42020182586.

Results

The electronic search identified 7,605 studies, of which 11 were selected, including three retrospective cohort and eight retrospective case control studies, overall reporting on 1,533 iSUA cases. The risk of delivering SGA neonates was increased in cases with iSUA (OR: 2.90; 95% CI: 2.02–4.18; p<0.00001; I2=71%). Similarly, iSUA was associated with an increased risk of pregnancy-induced hypertension (PIH) (OR: 2.23; 95% CI: 1.41–3.54; p<0.000; I2=1%), intrauterine death (IUD) (OR: 2.62; 95% CI: 1.43–4.79; p=0.002; I2=0%), preterm birth (PTB) (OR: 2.48; 95% CI: 1.73–3.56; p<0.00001; I2=56%), cesarean section (CS) (OR: 1.64; 95% CI: 1.11–2.41; p=0.01; I2=78%) and admission to neonatal intensive care unit (NICU) (OR: 2.28; 95% CI: 1.52–3.44; p<0.000001; I2=73%).

Conclusions

In prenatally diagnosed iSUA there is a higher risk of SGA, PIH, IUD, PTB, CS and NICU admission. These findings support the value of prenatal diagnosis of iSUA, which may subsequently intensify surveillance for the detection of specific pregnancy complications.

Keywords: birth weight; cesarean; hypertension; mortality; NICU; outcome; preterm birth; single umbilical artery; small for gestational age (SGA)
Corresponding author: Dr. Alexandros Sotiriadis, Second Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 92 Tsimiski Street 546 22 Thessaloniki, Greece, Phone: +30 2310230283, Fax: +30 2310230278, E-mail:

  1. Research funding: None declared.

  2. Author contributions: Themistoklis Dagklis developed the project, participated in data collection/analysis and the manuscript writing. Antonios Siargkas designed, coordinated, implemented the project, evaluated the results and participated in manuscript writing. Aikaterini Apostolopoulou participated in data analysis and manuscript writing. Ioannis Tsakiridis coordinated the project and participated in manuscript writing/editing. Apostolos Mamopoulos and Apostolos Athanasiadis participated in manuscript editing. Alexandros Sotiriadis participated in manuscript editing and data collection/analysis. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jpm-2021-0260).

Received: 2021-05-22
Accepted: 2021-11-11
Published Online: 2021-12-07
Published in Print: 2022-03-28

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Corner of Academy
  3. Cost of providing cell-free DNA screening for Down syndrome in Finland using different strategies
  4. Adverse perinatal outcomes following the prenatal diagnosis of isolated single umbilical artery in singleton pregnancies: a systematic review and meta-analysis
  5. Original Articles – Obstetrics
  6. Perinatal outcomes in women with severe acute respiratory syndrome coronavirus 2 infection: comparison with contemporary and matched pre-COVID-19 controls
  7. The postpartum period during the COVID-19 pandemic: investigating Turkish women’s postpartum support and postpartum-specific anxiety
  8. First-line noninvasive management of cytomegalovirus primary infection in pregnancy
  9. Ultrasound and magnetic resonance imaging in the diagnosis of clinically significant placenta accreta spectrum disorders
  10. Improved management of placenta accreta spectrum disorders: experience from a single institution
  11. A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations
  12. The impact of preimplantation genetic testing for aneuploidy on prenatal screening
  13. Original Articles – Fetus
  14. Myocardial deformation analysis in late-onset small-for-gestational-age and growth-restricted fetuses using two-dimensional speckle tracking echocardiography: a prospective cohort study
  15. HDlive Flow Silhouette with spatiotemporal image correlation for assessment of fetal cardiac structures at 12 to 14 + 6 weeks of gestation
  16. Umbilical artery pulsatility index and half-peak systolic velocity in second- and third-trimester fetuses with trisomy 18 and 13
  17. Original Articles – Neonates
  18. Pulmonary hypertension in infants with bronchopulmonary dysplasia: risk factors, mortality and duration of hospitalisation
  19. Outcomes from birth to 6 months of publicly insured infants born to mothers with severe acute respiratory syndrome coronavirus 2 infection in the United States
  20. Placental findings are not associated with neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy – an 11-year single-center experience
  21. High frequency band limits in spectral analysis of heart rate variability in preterm infants
  22. Bacterial DNA detection in very preterm infants assessed for risk of early onset sepsis
  23. Short Communication
  24. Healthcare workers’ attitudes about vaccination of pregnant women and those wishing to become pregnant
  25. Letter to the Editors
  26. Comment on Abdel Wahab et al.: A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations
  27. Re: Comment on Abdel Wahab et al.: A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations
  28. SARS-CoV-2 behavior, through the eyes of a perinatologist?
  29. Re: SARS-CoV-2 behavior, through the eyes of a perinatologist?
https://doi.org/10.1515/jpm-2021-0260
Schlagwörter für diesen Artikel
birth weight; cesarean; hypertension; mortality; NICU; outcome; preterm birth; single umbilical artery; small for gestational age (SGA)

Artikel in diesem Heft

  1. Frontmatter
  2. Corner of Academy
  3. Cost of providing cell-free DNA screening for Down syndrome in Finland using different strategies
  4. Adverse perinatal outcomes following the prenatal diagnosis of isolated single umbilical artery in singleton pregnancies: a systematic review and meta-analysis
  5. Original Articles – Obstetrics
  6. Perinatal outcomes in women with severe acute respiratory syndrome coronavirus 2 infection: comparison with contemporary and matched pre-COVID-19 controls
  7. The postpartum period during the COVID-19 pandemic: investigating Turkish women’s postpartum support and postpartum-specific anxiety
  8. First-line noninvasive management of cytomegalovirus primary infection in pregnancy
  9. Ultrasound and magnetic resonance imaging in the diagnosis of clinically significant placenta accreta spectrum disorders
  10. Improved management of placenta accreta spectrum disorders: experience from a single institution
  11. A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations
  12. The impact of preimplantation genetic testing for aneuploidy on prenatal screening
  13. Original Articles – Fetus
  14. Myocardial deformation analysis in late-onset small-for-gestational-age and growth-restricted fetuses using two-dimensional speckle tracking echocardiography: a prospective cohort study
  15. HDlive Flow Silhouette with spatiotemporal image correlation for assessment of fetal cardiac structures at 12 to 14 + 6 weeks of gestation
  16. Umbilical artery pulsatility index and half-peak systolic velocity in second- and third-trimester fetuses with trisomy 18 and 13
  17. Original Articles – Neonates
  18. Pulmonary hypertension in infants with bronchopulmonary dysplasia: risk factors, mortality and duration of hospitalisation
  19. Outcomes from birth to 6 months of publicly insured infants born to mothers with severe acute respiratory syndrome coronavirus 2 infection in the United States
  20. Placental findings are not associated with neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy – an 11-year single-center experience
  21. High frequency band limits in spectral analysis of heart rate variability in preterm infants
  22. Bacterial DNA detection in very preterm infants assessed for risk of early onset sepsis
  23. Short Communication
  24. Healthcare workers’ attitudes about vaccination of pregnant women and those wishing to become pregnant
  25. Letter to the Editors
  26. Comment on Abdel Wahab et al.: A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations
  27. Re: Comment on Abdel Wahab et al.: A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations
  28. SARS-CoV-2 behavior, through the eyes of a perinatologist?
  29. Re: SARS-CoV-2 behavior, through the eyes of a perinatologist?
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