Umbilical artery pulsatility index and half-peak systolic velocity in second- and third-trimester fetuses with trisomy 18 and 13
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Juan Carlos Bustos
,
Denise Vega
Abstract
Objectives
To analyze umbilical artery (UA) Doppler velocimetry and its possible role in placenta-mediated fetal growth restriction (FGR) in second- and third-trimester fetuses with trisomy 18 and 13.
Methods
UA pulsatility index (PI) and half-peak systolic velocity deceleration time (hPSV-DT) were measured in fetuses with trisomy 18 and 13. Correlation with gestational age, birthweight, and perinatal outcome was analyzed.
Results
A total of 80 measurements were taken from 33 fetuses with trisomy 18 and 19 with trisomy 13. Overall, there was a high prevalence of abnormal UA Doppler velocimetry. In fetuses with trisomy 18, 54% (27/50) of the UA PI values and 58% (29/50) of the UA hPSV-DT values were abnormal. In fetuses with trisomy 13, 80% (24/30) of the UA PI values and 87% (26/30) of the UA hPSV-DT values were abnormal. The prevalence of abnormal UA Doppler velocimetry increased with gestational age in both types of aneuploidy. However, this trend was only significant for trisomy 13 (p<0.05). All fetuses with trisomy 18 and 86% of fetuses with trisomy 13 were classified at birth as FGR. There were no perinatal survivors in this series.
Conclusions
A high prevalence of abnormal UA Doppler velocimetry was found in second- and third-trimester fetuses with trisomy 18 and 13, which further increased with gestational age. These results may well correlate with alterations described previously in the placenta, suggesting placental insufficiency has an important role in the development of FGR in these autosomal aneuploid fetuses.
Funding source: Sociedad Profesional de Medicina Fetal ‘Fetalmed’ Ltda., Chile
Award Identifier / Grant number: Unrestricted Research Grant
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Research funding: W.S. was supported by an Unrestricted Research Grant from the Sociedad Profesional de Medicina Fetal ‘Fetalmed’ Ltda., Chile.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The local Institutional Review Board deemed the study exempt from review.
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Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Corner of Academy
- Cost of providing cell-free DNA screening for Down syndrome in Finland using different strategies
- Adverse perinatal outcomes following the prenatal diagnosis of isolated single umbilical artery in singleton pregnancies: a systematic review and meta-analysis
- Original Articles – Obstetrics
- Perinatal outcomes in women with severe acute respiratory syndrome coronavirus 2 infection: comparison with contemporary and matched pre-COVID-19 controls
- The postpartum period during the COVID-19 pandemic: investigating Turkish women’s postpartum support and postpartum-specific anxiety
- First-line noninvasive management of cytomegalovirus primary infection in pregnancy
- Ultrasound and magnetic resonance imaging in the diagnosis of clinically significant placenta accreta spectrum disorders
- Improved management of placenta accreta spectrum disorders: experience from a single institution
- A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations
- The impact of preimplantation genetic testing for aneuploidy on prenatal screening
- Original Articles – Fetus
- Myocardial deformation analysis in late-onset small-for-gestational-age and growth-restricted fetuses using two-dimensional speckle tracking echocardiography: a prospective cohort study
- HDlive Flow Silhouette with spatiotemporal image correlation for assessment of fetal cardiac structures at 12 to 14 + 6 weeks of gestation
- Umbilical artery pulsatility index and half-peak systolic velocity in second- and third-trimester fetuses with trisomy 18 and 13
- Original Articles – Neonates
- Pulmonary hypertension in infants with bronchopulmonary dysplasia: risk factors, mortality and duration of hospitalisation
- Outcomes from birth to 6 months of publicly insured infants born to mothers with severe acute respiratory syndrome coronavirus 2 infection in the United States
- Placental findings are not associated with neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy – an 11-year single-center experience
- High frequency band limits in spectral analysis of heart rate variability in preterm infants
- Bacterial DNA detection in very preterm infants assessed for risk of early onset sepsis
- Short Communication
- Healthcare workers’ attitudes about vaccination of pregnant women and those wishing to become pregnant
- Letter to the Editors
- Comment on Abdel Wahab et al.: A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations
- Re: Comment on Abdel Wahab et al.: A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations
- SARS-CoV-2 behavior, through the eyes of a perinatologist?
- Re: SARS-CoV-2 behavior, through the eyes of a perinatologist?
Artikel in diesem Heft
- Frontmatter
- Corner of Academy
- Cost of providing cell-free DNA screening for Down syndrome in Finland using different strategies
- Adverse perinatal outcomes following the prenatal diagnosis of isolated single umbilical artery in singleton pregnancies: a systematic review and meta-analysis
- Original Articles – Obstetrics
- Perinatal outcomes in women with severe acute respiratory syndrome coronavirus 2 infection: comparison with contemporary and matched pre-COVID-19 controls
- The postpartum period during the COVID-19 pandemic: investigating Turkish women’s postpartum support and postpartum-specific anxiety
- First-line noninvasive management of cytomegalovirus primary infection in pregnancy
- Ultrasound and magnetic resonance imaging in the diagnosis of clinically significant placenta accreta spectrum disorders
- Improved management of placenta accreta spectrum disorders: experience from a single institution
- A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations
- The impact of preimplantation genetic testing for aneuploidy on prenatal screening
- Original Articles – Fetus
- Myocardial deformation analysis in late-onset small-for-gestational-age and growth-restricted fetuses using two-dimensional speckle tracking echocardiography: a prospective cohort study
- HDlive Flow Silhouette with spatiotemporal image correlation for assessment of fetal cardiac structures at 12 to 14 + 6 weeks of gestation
- Umbilical artery pulsatility index and half-peak systolic velocity in second- and third-trimester fetuses with trisomy 18 and 13
- Original Articles – Neonates
- Pulmonary hypertension in infants with bronchopulmonary dysplasia: risk factors, mortality and duration of hospitalisation
- Outcomes from birth to 6 months of publicly insured infants born to mothers with severe acute respiratory syndrome coronavirus 2 infection in the United States
- Placental findings are not associated with neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy – an 11-year single-center experience
- High frequency band limits in spectral analysis of heart rate variability in preterm infants
- Bacterial DNA detection in very preterm infants assessed for risk of early onset sepsis
- Short Communication
- Healthcare workers’ attitudes about vaccination of pregnant women and those wishing to become pregnant
- Letter to the Editors
- Comment on Abdel Wahab et al.: A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations
- Re: Comment on Abdel Wahab et al.: A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations
- SARS-CoV-2 behavior, through the eyes of a perinatologist?
- Re: SARS-CoV-2 behavior, through the eyes of a perinatologist?
