Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome
Abstract
Objective: To examine potential correlations between maternal serum placental protein-13 (PP-13) and first trimester maternal and placental factors, and to evaluate the association of this marker with adverse pregnancy outcome.
Methods: Serum samples from prospectively enrolled patients between 11 and 13 weeks and 6 days were analyzed for PP-13 using an ELISA assay. The relationships between maternal serum PP-13 levels and gestational age, maternal age, ethnicity, parity, smoking status, body mass index (BMI), mean arterial blood pressure, uterine and umbilical artery Doppler parameters were examined. The association between first-trimester PP-13 levels and subsequent pre-eclampsia and delivery of a small for gestational age (SGA) neonate was also investigated, after excluding patients who received aspirin.
Results: In 908 patients, PP-13 levels ranged from 8.0 to 537.5 pg/mL. A significant negative correlation was identified between PP13 and BMI (Spearman rho –0.20, P<0.0001). Smoking significantly decreased PP-13 (P<0.01). No relationship was identified with the other parameters. In a subgroup of 668 low-risk patients who did not receive aspirin, PP-13 levels were not associated with development of pre-eclampsia, SGA or the combination of them.
Conclusion: First-trimester PP-13 levels are significantly correlated with BMI and smoking. These correlations appear independent of uterine and umbilical artery resistance. In low risk patients, PP-13 levels fail to predict the risk for pre-eclampsia or SGA.
Acknowledgment
This study was supported by a grant from Diagnostic Technologies Limited until the company stopped its operation. HM obtained support from EU FP7 grant ASPRE.
References
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The authors stated that there are no conflicts of interest regarding the publication of this article.
©2016 by De Gruyter
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- Editorial
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- Original articles
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- Computerized vital signs analysis and late onset infections in extremely low gestational age infants
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- Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study
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- Amniotic fluid LPCAT1 mRNA correlates with the lamellar body count
- Recommendation and Guidelines for Perinatal Practice
- Fetal magnetic resonance imaging and ultrasound
- Original articles - Obstetrics
- Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome
- Higher D-dimer level in the early third trimester predicts the occurrence of postpartum hemorrhage
- Extra-abdominal removal of placenta during cesarean section: a prospective randomized controlled trial of a novel technique
- Correlation of intrapartum translabial ultrasound parameters with computed tomographic 3D reconstruction of the female pelvis
- Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit
- Original articles - Fetus
- Is there a sex difference in fetal behavior? A comparison of the KANET test between male and female fetuses
- Determination of antepartum and intrapartum risk factors associated with neonatal intensive care unit admission
- Short communication
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- Congress Calendar
- Congress Calendar
Articles in the same Issue
- Frontmatter
- Editorial
- Preventing preterm birth
- Original articles
- Vertically transmitted cytomegalovirus infection in newborn preterm infants
- Computerized vital signs analysis and late onset infections in extremely low gestational age infants
- Oral propranolol in early stages of retinopathy of prematurity
- Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study
- Predictive factors for preterm delivery under rural conditions in post-tsunami Banda Aceh
- Early pregnancy serum neopterin concentrations predict spontaneous preterm birth in asymptomatic pregnant women
- Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes
- Amniotic fluid LPCAT1 mRNA correlates with the lamellar body count
- Recommendation and Guidelines for Perinatal Practice
- Fetal magnetic resonance imaging and ultrasound
- Original articles - Obstetrics
- Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome
- Higher D-dimer level in the early third trimester predicts the occurrence of postpartum hemorrhage
- Extra-abdominal removal of placenta during cesarean section: a prospective randomized controlled trial of a novel technique
- Correlation of intrapartum translabial ultrasound parameters with computed tomographic 3D reconstruction of the female pelvis
- Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit
- Original articles - Fetus
- Is there a sex difference in fetal behavior? A comparison of the KANET test between male and female fetuses
- Determination of antepartum and intrapartum risk factors associated with neonatal intensive care unit admission
- Short communication
- A guide on how to build a novel home-made part task training simulator for cervical cerclage training
- Congress Calendar
- Congress Calendar