Home Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit
Article
Licensed
Unlicensed Requires Authentication

Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit

  • Christopher R.H. White EMAIL logo , Dorota A. Doherty , Jeffrey W. Cannon , Rolland Kohan , John P. Newnham and Craig E. Pennell
Published/Copyright: March 11, 2016

Abstract

Objective: There is an increasing body of literature supporting universal umbilical cord blood gas analysis (UCBGA) into all maternity units. A significant impediment to UCBGA’s introduction is the perceived expense of the introduction and associated ongoing costs. Consequently, this study set out to conduct the first cost-effectiveness analysis of introducing universal UCBGA.

Methods: Analysis was based on 42,100 consecutive deliveries ≥23 weeks of gestation at a single tertiary obstetric unit. Within 4 years of UCBGA’s introduction there was a 45% reduction in term special care nursery (SCN) admissions >2499 g. Incurred costs included initial and ongoing costs associated with universal UCBGA. Averted costs were based on local diagnosis-related grouping costs for reduction in term SCN admissions. Incremental cost-effectiveness ratio (ICER) and sensitivity analysis results were reported.

Results: Under the base-case scenario, the adoption of universal UCBGA was less costly and more effective than selective UCBGA over 4 years and resulted in saving of AU$641,532 while adverting 376 SCN admissions. Sensitivity analysis showed that UCBGA was cost-effective in 51.8%, 83.3%, 99.6% and 100% of simulations in years 1, 2, 3 and 4. These conclusions were not sensitive to wide, clinically possible variations in parameter values for neonatal intensive care unit and SCN admissions, magnitude of averted SCN admissions, cumulative delivery numbers, and SCN admission costs.

Conclusions: Universal UCBGA is associated with significant initial and ongoing costs; however, potential averted costs (due to reduced SCN admissions) exceed incurred costs in most scenarios.


Corresponding author: Dr Christopher R.H. White, School of Women’s and Infants’ Health M550, The University of Western Australia, 35 Stirling Highway, Crawley Western Australia 6009, Perth, Western Australia, Australia, Tel.: (+61 8) 9340 1331, Fax: (+61 8) 9381 3031, E-mail:

References

[1] MacLennan A. A template for defining a causal relation between acute intrapartum events and cerebral palsy: international consensus statement. Br Med J. 1999;319:1054–9.10.1136/bmj.319.7216.1054Search in Google Scholar

[2] ACOG, AAP. Neonatal encephalopathy and cerebral palsy: defining the pathogenesis and pathophysiology. Washington, DC: American College of Obstetricians and Gynecologists; 2003.Search in Google Scholar

[3] Harris M, Beckley SL, Garibaldi JM, Keith RD, Greene KR. Umbilical cord blood gas analysis at the time of delivery. Midwifery. 1996;12:146–50.10.1016/S0266-6138(96)90059-5Search in Google Scholar

[4] Thorp JA, Rushing RS. Umbilical cord blood gas analysis. Obstet Gynecol Clin North Am. 1999;26:695–709.10.1016/S0889-8545(05)70107-8Search in Google Scholar

[5] Garibaldi JM, Westgate JA, Ifeachor EC. The evaluation of an expert system for the analysis of umbilical cord blood. Artif Intell Med. 1999;17:109–30.10.1016/S0933-3657(99)00020-2Search in Google Scholar

[6] Malin GL, Morris RK, Khan KS. Strength of association between umbilical cord pH and perinatal and long term outcomes: systematic review and meta-analysis. Br Med J. 2010;340:c1471.10.1097/01.aoa.0000397115.97213.02Search in Google Scholar

[7] White CR, Doherty DA, Henderson JJ, Kohan R, Newnham JP, Pennell CE. Benefits of introducing universal umbilical cord blood gas and lactate analysis into an obstetric unit. Aust N Z J Obstet Gynaecol. 2010;50:318–28.10.1111/j.1479-828X.2010.01192.xSearch in Google Scholar

[8] Duerbeck NB, Chaffin DG, Seeds JW. A practical approach to umbilical artery pH and blood gas determinations. Obstet Gynecol. 1992;79:959–62.Search in Google Scholar

[9] Thorp J, Dildy G, Yeomans E, Meyer B, Parisi V. Umbilical cord blood gas analysis at delivery. Am J Obstet Gynecol. 1996;175:517–22.10.1053/ob.1996.v175.a74401Search in Google Scholar

[10] ACOG. ACOG technical bulletin no. 216: umbilical artery blood acid-base analysis. Int J Gynaecol Obstet. 1996;52:305–10.Search in Google Scholar

[11] Huch A, Huch R, Rooth G. Guidelines for blood sampling and measurement of pH and blood gas values in obstetrics. Based upon a workshop held in Zurich, Switzerland, March 19, 1993 by an Ad Hoc Committee. Eur J Obstet Gynecol Reprod Biol. 1994;54:165–75.10.1016/0028-2243(94)90277-1Search in Google Scholar

[12] Australian Government Department of Health and Aging. National Hospital Cost Data Collection: Cost Report Round 13 (2008–2009) Public Hospitals: AR-DRG 5.2. Canberra, Australia; 2010.Search in Google Scholar

[13] Commonwealth Department of Health and Aging. National Hospital Cost Data Collection Cost Report Round 13 (2008–2009) Public Hospitals: AR-DRG 5.2. Canberra; 2010.Search in Google Scholar

[14] Duckett SJ. Casemix funding for acute hospital inpatient services in Australia. Med J Aust. 1998;169(Suppl):S17–21.10.5694/j.1326-5377.1998.tb123470.xSearch in Google Scholar PubMed

[15] Raftery J. NICE: faster access to modern treatments? Analysis of guidance on health technologies. Br Med J. 2001;323: 1300–3.10.1136/bmj.323.7324.1300Search in Google Scholar PubMed PubMed Central

[16] Doubilet P, Begg CB, Weinstein MC, Braun P, McNeil BJ. Probabilistic sensitivity analysis using Monte Carlo simulation. A practical approach. Med Decis Making. 1985;5:157–77.10.1177/0272989X8500500205Search in Google Scholar PubMed

[17] Briggs AH, Goeree R, Blackhouse G, O’Brien BJ. Probabilistic analysis of cost-effectiveness models: choosing between treatment strategies for gastroesophageal reflux disease. Med Decis Making. [Research Support, Non-U.S. Gov’t]. 2002;22:290–308.10.1177/027298902400448867Search in Google Scholar

[18] Boldt J, Kumle B, Suttner S, Haisch G. Point-of-care (POC) testing of lactate in the intensive care patient. Accuracy, reliability, and costs of different measurement systems. Acta Anaesthesiol Scand. 2001;45:194–9.10.1034/j.1399-6576.2001.450210.xSearch in Google Scholar PubMed

[19] Pennell CE, Tracy MB. A new method for rapid measurement of lactate in fetal and neonatal blood. Aust N Z J Obstet Gynaecol. 1999;39:227–33.10.1111/j.1479-828X.1999.tb03379.xSearch in Google Scholar PubMed

[20] Ramanah R, Martin A, Clement MC, Maillet R, Riethmuller D. Fetal scalp lactate microsampling for non-reassuring fetal status during labor: a prospective observational study. Fetal Diagn Ther. 2010;27:14–9.10.1159/000262281Search in Google Scholar PubMed

[21] Westgren M, Kruger K, Ek S, Grunevald C, Kublickas M, Naka K, et al. Lactate compared with pH analysis at fetal scalp blood sampling: a prospective randomised study. Br J Obstet Gynaecol. 1998;105:29–33.10.1111/j.1471-0528.1998.tb09346.xSearch in Google Scholar PubMed

[22] RCOG. The use and interpretation of cardiotocography in intrapartum fetal surveillance. London: Royal College of Obstetricans and Gynaecologists; 2001.Search in Google Scholar

[23] ACOG. ACOG Committee Opinion No. 348: Umbilical cord blood gas and acid-base analysis. Obstet Gynecol. 2006;108:1319–22.10.1097/00006250-200611000-00058Search in Google Scholar PubMed

[24] Gilstrap LC, 3rd. Fetal acid-base balance. In: Creasy RK, Resnik R, Iams JD, editors. Maternal-fetal medicine: principles and practice. 5th ed. Philadelphia: Saunders; 2004. p. 429–39.Search in Google Scholar

[25] RCOG, RCM. Towards safer childbirth. Minimum standards for the organisation of labour wards. Report of a joint working party. London: RCOG1999.Search in Google Scholar

[26] White CRH, Doherty DA, Newnham JP, Pennell CE. The impact of introducing universal umbilical cord blood gas analysis and lactate measurement at delivery. Aust N Z J Obstet Gynaecol. 2014;54:71–8.10.1111/ajo.12132Search in Google Scholar PubMed

[27] Australian Institute of Health and Welfare. Australia’s mothers and babies 2013 – in brief. Perinatal statistics series. Canberra: AIHW; 2015.Search in Google Scholar

[28] Robson SJ, Laws P, Sullivan EA. Adverse outcomes of labour in public and private hospitals in Australia: a population-based descriptive study. Med J Aust. 2009;190:474–7.10.5694/j.1326-5377.2009.tb02521.xSearch in Google Scholar

[29] AIHW. Medical Indemnity National Data Collection Public Sector 2005-06. Canberra: AIHW2007. Report No.: HSE 52.Search in Google Scholar

[30] MacLennan A, Nelson KB, Hankins G, Speer M. Who will deliver our grandchildren? Implications of cerebral palsy litigation. J Am Med Assoc. 2005;294:1688–90.10.1001/jama.294.13.1688Search in Google Scholar PubMed

[31] MacLennan AH, Spencer MK. Projections of Australian obstetricians ceasing practice and the reasons. Med J Aust. 2002;176:425–8.10.5694/j.1326-5377.2002.tb04484.xSearch in Google Scholar PubMed

[32] Access Economics Pty Limited for Cerebral Palsy Australia. The Economic Impact of Cerebral Palsy in Australia in 2007: Cerebral Palsy Australia; 2008.Search in Google Scholar

  1. The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2015-11-24
Accepted: 2016-2-8
Published Online: 2016-3-11
Published in Print: 2016-7-1

©2016 by De Gruyter

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Preventing preterm birth
  4. Original articles
  5. Vertically transmitted cytomegalovirus infection in newborn preterm infants
  6. Computerized vital signs analysis and late onset infections in extremely low gestational age infants
  7. Oral propranolol in early stages of retinopathy of prematurity
  8. Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study
  9. Predictive factors for preterm delivery under rural conditions in post-tsunami Banda Aceh
  10. Early pregnancy serum neopterin concentrations predict spontaneous preterm birth in asymptomatic pregnant women
  11. Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes
  12. Amniotic fluid LPCAT1 mRNA correlates with the lamellar body count
  13. Recommendation and Guidelines for Perinatal Practice
  14. Fetal magnetic resonance imaging and ultrasound
  15. Original articles - Obstetrics
  16. Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome
  17. Higher D-dimer level in the early third trimester predicts the occurrence of postpartum hemorrhage
  18. Extra-abdominal removal of placenta during cesarean section: a prospective randomized controlled trial of a novel technique
  19. Correlation of intrapartum translabial ultrasound parameters with computed tomographic 3D reconstruction of the female pelvis
  20. Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit
  21. Original articles - Fetus
  22. Is there a sex difference in fetal behavior? A comparison of the KANET test between male and female fetuses
  23. Determination of antepartum and intrapartum risk factors associated with neonatal intensive care unit admission
  24. Short communication
  25. A guide on how to build a novel home-made part task training simulator for cervical cerclage training
  26. Congress Calendar
  27. Congress Calendar
Downloaded on 29.11.2025 from https://www.degruyterbrill.com/document/doi/10.1515/jpm-2015-0398/html
Scroll to top button