Early pregnancy serum neopterin concentrations predict spontaneous preterm birth in asymptomatic pregnant women
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Dan Bogdan Navolan
, Simona Vladareanu
, Imad Lahdou , Ioana Ciohat , Christian Kleist , Dorin Grigoras , Radu Vladareanu , Peter Terness and Ioan Sas
Abstract
Objective: To investigate if early pregnancy serum neopterin concentrations (EPSN) could predict spontaneous preterm birth (SPB).
Methods: EPSN was measured in 92 sera collected from 46 pregnant women with birth at term and 40 sera from 20 pregnant women with preterm birth. Two sera were collected for each case: in the first and early second trimester.
Results: EPSN concentrations correlate with gestational age (ρ=0.275, P=0.001), a correlation which was present in both groups: term and preterm birth. EPSN were higher in pregnancies with SPB compared with normal pregnancies (6.27±1.03 vs. 6.04±0.15, P=0.039). Patients with SPB showed a considerable increase of EPSN in the second trimester compared with patients with birth at term (7.30±1.53 vs. 6.16±0.23, P=0.043). A sharper increase was found in the group with SPB before 32 weeks of pregnancy (wp) (9.83±4.36 vs. 6.16±0.23, P=0.016). Pregnant women with an early second trimester serum neopterin value of above 8 nmol/L are associated with a risk of SPB before 32 wp (odds ratio=14.4, P=0.01) and of SPB before 34 wp (odds ratio=3.6, P=0.05), respectively.
Conclusions: EPSN increases with the gestational age and predicts SPB in asymptomatic pregnant women.
References
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©2016 by De Gruyter
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- Editorial
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- Computerized vital signs analysis and late onset infections in extremely low gestational age infants
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- Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study
- Predictive factors for preterm delivery under rural conditions in post-tsunami Banda Aceh
- Early pregnancy serum neopterin concentrations predict spontaneous preterm birth in asymptomatic pregnant women
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- Recommendation and Guidelines for Perinatal Practice
- Fetal magnetic resonance imaging and ultrasound
- Original articles - Obstetrics
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- Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit
- Original articles - Fetus
- Is there a sex difference in fetal behavior? A comparison of the KANET test between male and female fetuses
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- Short communication
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- Congress Calendar
- Congress Calendar
Articles in the same Issue
- Frontmatter
- Editorial
- Preventing preterm birth
- Original articles
- Vertically transmitted cytomegalovirus infection in newborn preterm infants
- Computerized vital signs analysis and late onset infections in extremely low gestational age infants
- Oral propranolol in early stages of retinopathy of prematurity
- Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study
- Predictive factors for preterm delivery under rural conditions in post-tsunami Banda Aceh
- Early pregnancy serum neopterin concentrations predict spontaneous preterm birth in asymptomatic pregnant women
- Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes
- Amniotic fluid LPCAT1 mRNA correlates with the lamellar body count
- Recommendation and Guidelines for Perinatal Practice
- Fetal magnetic resonance imaging and ultrasound
- Original articles - Obstetrics
- Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome
- Higher D-dimer level in the early third trimester predicts the occurrence of postpartum hemorrhage
- Extra-abdominal removal of placenta during cesarean section: a prospective randomized controlled trial of a novel technique
- Correlation of intrapartum translabial ultrasound parameters with computed tomographic 3D reconstruction of the female pelvis
- Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit
- Original articles - Fetus
- Is there a sex difference in fetal behavior? A comparison of the KANET test between male and female fetuses
- Determination of antepartum and intrapartum risk factors associated with neonatal intensive care unit admission
- Short communication
- A guide on how to build a novel home-made part task training simulator for cervical cerclage training
- Congress Calendar
- Congress Calendar