Oral propranolol in early stages of retinopathy of prematurity
-
Aldo Bancalari
,
Ricardo Schade
Abstract
Objective: To assess the effect of oral propranolol on the progression of early stages of retinopathy of prematurity (ROP) in very low birth weight (VLBW) infants.
Methods: We analyzed VLBW infants with ROP (stages 2–3, zones II-III). Newborns received oral propranolol (0.5 mg/kg/dose q8h), and were monitored throughout the treatment period for possible side effects. Propranolol was administered until regression of ROP. A historic control group of patients with equivalent ROP was used. We compared characteristics of both groups and the progression of retinopathy.
Results: Forty-seven newborns were included, 20 in the propranolol group and 27 in the control group. There were no significant differences in gestational age, birthweight or gender. The mean duration of treatment with propranolol was 58.2±17.6 days. Most patients started treatment with stage 2 disease (65.0%), and had zone III involvement (55.0%). In the treated group, 90.0% (18/20) of patients did not require intervention with laser or bevacizumab, compared to 51.8% in the control group (P<0.005). No cases of bradycardia, hypotension or hypoglycemia were observed.
Conclusions: Oral propranolol in early stages of ROP could prevent disease progression and reduce the need for invasive rescue therapy with laser or bevacizumab. No significant side effects were reported.
Funding: No additional funding, equipment or supplies were necessary.
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©2016 by De Gruyter
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Articles in the same Issue
- Frontmatter
- Editorial
- Preventing preterm birth
- Original articles
- Vertically transmitted cytomegalovirus infection in newborn preterm infants
- Computerized vital signs analysis and late onset infections in extremely low gestational age infants
- Oral propranolol in early stages of retinopathy of prematurity
- Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study
- Predictive factors for preterm delivery under rural conditions in post-tsunami Banda Aceh
- Early pregnancy serum neopterin concentrations predict spontaneous preterm birth in asymptomatic pregnant women
- Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes
- Amniotic fluid LPCAT1 mRNA correlates with the lamellar body count
- Recommendation and Guidelines for Perinatal Practice
- Fetal magnetic resonance imaging and ultrasound
- Original articles - Obstetrics
- Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome
- Higher D-dimer level in the early third trimester predicts the occurrence of postpartum hemorrhage
- Extra-abdominal removal of placenta during cesarean section: a prospective randomized controlled trial of a novel technique
- Correlation of intrapartum translabial ultrasound parameters with computed tomographic 3D reconstruction of the female pelvis
- Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit
- Original articles - Fetus
- Is there a sex difference in fetal behavior? A comparison of the KANET test between male and female fetuses
- Determination of antepartum and intrapartum risk factors associated with neonatal intensive care unit admission
- Short communication
- A guide on how to build a novel home-made part task training simulator for cervical cerclage training
- Congress Calendar
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