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Amniotic fluid LPCAT1 mRNA correlates with the lamellar body count

  • Robert A. Welch EMAIL logo , Michael K. Shaw and Kathryn C. Welch
Published/Copyright: May 12, 2015
Journal of Perinatal Medicine
From the journal Journal of Perinatal Medicine Volume 44 Issue 5

Abstract

Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is required in the biosynthesis of pulmonary surfactant. This short communication describes our assessment of LPCAT1 mRNA levels in human amniotic fluid. We found a direct correlation between LPCAT1 mRNA copies and the amniotic fluid lamellar body count (LBC). This finding corroborates an association between LPCAT1 and surfactant phospholipid biosynthesis in humans. It may provide a model for future research in perinatal medicine.

Keywords: Lamellar body count; LPCAT1; surfactant
Corresponding author: Robert A. Welch, MD, Wayne State University School of Medicine, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Hutzel Hospital, 7 Brush North, 3990 John R, Detroit, MI 48201, Tel.: 734-223-1926, Fax: 313-993-4100, E-mail:

References

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  1. The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2015-1-6
Accepted: 2015-3-20
Published Online: 2015-5-12
Published in Print: 2016-7-1

©2016 by De Gruyter

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https://doi.org/10.1515/jpm-2015-0008
Keywords for this article
Lamellar body count; LPCAT1; surfactant

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Preventing preterm birth
  4. Original articles
  5. Vertically transmitted cytomegalovirus infection in newborn preterm infants
  6. Computerized vital signs analysis and late onset infections in extremely low gestational age infants
  7. Oral propranolol in early stages of retinopathy of prematurity
  8. Changes in incidence of iatrogenic and spontaneous preterm births over time: a population-based study
  9. Predictive factors for preterm delivery under rural conditions in post-tsunami Banda Aceh
  10. Early pregnancy serum neopterin concentrations predict spontaneous preterm birth in asymptomatic pregnant women
  11. Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes
  12. Amniotic fluid LPCAT1 mRNA correlates with the lamellar body count
  13. Recommendation and Guidelines for Perinatal Practice
  14. Fetal magnetic resonance imaging and ultrasound
  15. Original articles - Obstetrics
  16. Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome
  17. Higher D-dimer level in the early third trimester predicts the occurrence of postpartum hemorrhage
  18. Extra-abdominal removal of placenta during cesarean section: a prospective randomized controlled trial of a novel technique
  19. Correlation of intrapartum translabial ultrasound parameters with computed tomographic 3D reconstruction of the female pelvis
  20. Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit
  21. Original articles - Fetus
  22. Is there a sex difference in fetal behavior? A comparison of the KANET test between male and female fetuses
  23. Determination of antepartum and intrapartum risk factors associated with neonatal intensive care unit admission
  24. Short communication
  25. A guide on how to build a novel home-made part task training simulator for cervical cerclage training
  26. Congress Calendar
  27. Congress Calendar
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