Combined spinal epidural analgesia for labor using sufentanil epidurally versus intrathecally: a retrospective study on the influence on fetal heart trace
Abstract
Objective: We retrospectively compared a protocol using sufentanil and ropivacaine intrathecally with a protocol in which only ropivacaine was administered intrathecally and sufentanil was used epidurally to evaluate whether banning sufentanil from the intrathecal space results in a decreased incidence of adverse fetal heart rate changes.
Methods: Some 520 cardiotocographic tracings were examined for changes in fetal heart rate and uterine activity following two different protocols of combined spinal epidural analgesia. Charts were consulted for neonatal and labor outcome.
Results: When sufentanil was used epidurally instead of intrathecally, the incidence of adverse changes in fetal heart trace was less, demonstrated by a higher percentage of normal reassuring tracings (74.5% vs. 60.4% when sufentanil was used intrathecally; P=0.007), less tracings showing bradycardia (7.5% vs. 14.1%; P=0.035), and more tracings displaying 3 or more accelerations in fetal heart rate in 45 min (93.5% vs. 83.9%; P=0.003) together with less episodes of tachycardia (3.5% vs. 11.4%; P=0.005). There were no differences in labor and neonatal outcome.
Conclusions: Based on fetal heart tracing, it seems favorable to ban sufentanil from the intrathecal compartment.
References
[1] Abrão KC, Francisco RP, Miyadahira S, Cicarelli DD, Zugaib M. Elevation of uterine basal tone and fetal heart rate abnormalities after labor analgesia: a randomized controlled trial. Obstet Gynecol. 2009;113:41–7.10.1097/AOG.0b013e31818f5eb6Suche in Google Scholar
[2] American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 106: intrapartumfetal heart rate monitoring: nomenclature, interpretation, and general management principles. Obstet Gynecol. 2009;114:192–202.10.1097/AOG.0b013e3181aef106Suche in Google Scholar
[3] Eberle RL, Norris MC, Eberle AM, Naulty JS, Arkoosh VA. The effect of maternal position on fetal heart rate during epidural or intrathecal labor analgesia. Am J Obstet Gynecol. 1999;179:150–5.10.1016/S0002-9378(98)70266-2Suche in Google Scholar
[4] FIGO Subcommittee on Standards in Perinatal Medicine. Guidelines for the use of fetal monitoring. Int J Gynaecol Obstet. 1987;25:159–67.Suche in Google Scholar
[5] Gaiser RR, McHugh M, Cheek TG, Gutsche BB. Predicting prolonged fetal heart rate deceleration following intrathecal fentanyl/bupivacaine. Int J Obstet Anesth. 2005;14:208–11.10.1016/j.ijoa.2004.12.010Suche in Google Scholar
[6] Hughes D, Simmons SW, Brown J, Cyna AM. Combined spinal-epidural analgesia in labour. Cochrane Database Syst Rev. 2003;4:CD003401.10.1002/14651858.CD003401Suche in Google Scholar
[7] Krebs HB, Petres RE, Dunn LJ, Smith PJ. Intrapartumfetal heart rate monitoring. VI. Prognostic significance of accelerations. Am J Obstet Gynecol. 1982;142:297–305.10.1016/0002-9378(82)90734-7Suche in Google Scholar
[8] Mardirosoff C, Dumont L, Boulvain M, Tramèr MR. Fetal bradycardia due to intrathecal opioids for labour analgesia: a systematic review. Br J Obstet Gynaecol. 2002;109:274–81.10.1111/j.1471-0528.2002.01380.xSuche in Google Scholar PubMed
[9] Nielsen PE, Erickson JR, Abouleish EI, Perriatt S, Sheppard C. Fetal heart rate changes after intrathecal sufentanil or epidural bupivacaine for labor analgesia: incidence and clinical significance. Anesth Analg. 1996;83:742–46.10.1213/00000539-199610000-00014Suche in Google Scholar
[10] Wong CA, Scavone BM, Peaceman AM, McCarthy RJ, Sullivan JT, Diaz NT, et al. The risk of cesarean delivery with neuraxial analgesia given early versus late in labor. N Engl J Med. 2005;352:655–65.10.1056/NEJMoa042573Suche in Google Scholar PubMed
The authors stated that there are no conflicts of interest regarding the publication of this article.
©2015 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Editorial
- Erich Saling – The Father of Prenatal and Perinatal Medicine—Dedication to his 90th birthday
- Original articles - Obstetrics
- A transcervical amniotic fluid collector: a new medical device for the assessment of amniotic fluid in patients with ruptured membranes
- Advanced cervical dilatation and spontaneous preterm labor: a comparison between twin and singleton gestations
- Comparison of a novel test for placental alpha microglobulin-1 with fetal fibronectin and cervical length measurement for the prediction of imminent spontaneous preterm delivery in patients with threatened preterm labor
- Does recent sexual intercourse during pregnancy affect the results of the fetal fibronectin rapid test? A comparative prospective study
- Usefulness of maternal serum C-reactive protein with vaginal Ureaplasma urealyticum as a marker for prediction of imminent preterm delivery and chorioamnionitis in patients with preterm labor or preterm premature rupture of membranes
- Effect of blood on ROM diagnosis accuracy of PAMG-1 and IGFBP-1 detecting rapid tests
- Single versus combination tocolytic regimen in the prevention of preterm births in women: a prospective cohort study
- Recommendations of activity restriction in high-risk pregnancy scenarios: a Danish national survey
- Is pharmacologic research on pregnant women with psychoses ethically permissible?
- Women’s knowledge and attitude towards pregnancy in a high-income developing country
- Impact of maternal body mass index on the cesarean delivery rate in Germany from 1990 to 2012
- Justified skepticism about Apgar scoring in out-of-hospital birth settings
- The effect of the use of oxytocin on blood loss during different postpartum periods
- Original articles - Fetus
- The T/QRS ratio values in pregnancies complicated by threatened preterm labour treated with intravenous infusions of fenoterol
- Cardiotocography patterns and risk of intrapartum fetal acidemia
- Combined spinal epidural analgesia for labor using sufentanil epidurally versus intrathecally: a retrospective study on the influence on fetal heart trace
- Original articles - Newborn
- Predicting fetal growth deviation in parous women: combining the birth weight of the previous pregnancy and third trimester ultrasound scan
- Letter to the Editor
- A cerclage is not a modified total cervical occlusion!
- Letter Reply
- Reply to: a cerclage is not a modified Total Cervical Occlusion!
- Congress Calendar
- Congress Calendar
Artikel in diesem Heft
- Frontmatter
- Editorial
- Erich Saling – The Father of Prenatal and Perinatal Medicine—Dedication to his 90th birthday
- Original articles - Obstetrics
- A transcervical amniotic fluid collector: a new medical device for the assessment of amniotic fluid in patients with ruptured membranes
- Advanced cervical dilatation and spontaneous preterm labor: a comparison between twin and singleton gestations
- Comparison of a novel test for placental alpha microglobulin-1 with fetal fibronectin and cervical length measurement for the prediction of imminent spontaneous preterm delivery in patients with threatened preterm labor
- Does recent sexual intercourse during pregnancy affect the results of the fetal fibronectin rapid test? A comparative prospective study
- Usefulness of maternal serum C-reactive protein with vaginal Ureaplasma urealyticum as a marker for prediction of imminent preterm delivery and chorioamnionitis in patients with preterm labor or preterm premature rupture of membranes
- Effect of blood on ROM diagnosis accuracy of PAMG-1 and IGFBP-1 detecting rapid tests
- Single versus combination tocolytic regimen in the prevention of preterm births in women: a prospective cohort study
- Recommendations of activity restriction in high-risk pregnancy scenarios: a Danish national survey
- Is pharmacologic research on pregnant women with psychoses ethically permissible?
- Women’s knowledge and attitude towards pregnancy in a high-income developing country
- Impact of maternal body mass index on the cesarean delivery rate in Germany from 1990 to 2012
- Justified skepticism about Apgar scoring in out-of-hospital birth settings
- The effect of the use of oxytocin on blood loss during different postpartum periods
- Original articles - Fetus
- The T/QRS ratio values in pregnancies complicated by threatened preterm labour treated with intravenous infusions of fenoterol
- Cardiotocography patterns and risk of intrapartum fetal acidemia
- Combined spinal epidural analgesia for labor using sufentanil epidurally versus intrathecally: a retrospective study on the influence on fetal heart trace
- Original articles - Newborn
- Predicting fetal growth deviation in parous women: combining the birth weight of the previous pregnancy and third trimester ultrasound scan
- Letter to the Editor
- A cerclage is not a modified total cervical occlusion!
- Letter Reply
- Reply to: a cerclage is not a modified Total Cervical Occlusion!
- Congress Calendar
- Congress Calendar