Single versus combination tocolytic regimen in the prevention of preterm births in women: a prospective cohort study
-
Qiu Ju Ng
,
Muhammad Fairuz Bin Abdul Rahman
Abstract
Objective: Our objective is to compare the efficacy of combination regimen (salbutamol and nifedipine) against single regimen (nifedipine alone) in preventing preterm births among women with preterm labor.
Results: A total of 76 women with gestational age (GA) ranging from 24+0 to 35+6 weeks, who sought treatment for preterm labor with or without cervical dilatation, were recruited for the prospective cohort study. Of these, 38 (50%) had single tocolytic regimen and 38 (50%) had combination tocolytic regimen. The mean GAs at admission were similar for both groups at 31 weeks (±2.93) for Group 1 and 30.9 weeks (±2.88) for Group 2 (P=0.873). The mean GAs at delivery were 37.8 weeks (±1.98) for the single regimen and 36.2 weeks (±3.26) for the combined regimen (P=0.011). The mean tocolytic to delivery interval for the single regimen was longer at 6.74 weeks (±3.13) as compared with 5.21 weeks (±3.61) for the combination regimen (P<0.05). Those on the combination regimen complained of more adverse effects (P<0.001).
Conclusion: Our study results suggested that the use of nifedipine as a single tocolytic regimen is as effective as the combination regimen in the delay of preterm births and has much less side effects. Hence, we recommend the sole use of nifedipine for the management of preterm labor.
Acknowledgments
The authors thank Ng Mor Jack for his statistical expertise and the Singhealth Foundation Grant (SHF/FG345S) for their support.
References
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The authors stated that there are no conflicts of interest regarding the publication of this article.
©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- Editorial
- Erich Saling – The Father of Prenatal and Perinatal Medicine—Dedication to his 90th birthday
- Original articles - Obstetrics
- A transcervical amniotic fluid collector: a new medical device for the assessment of amniotic fluid in patients with ruptured membranes
- Advanced cervical dilatation and spontaneous preterm labor: a comparison between twin and singleton gestations
- Comparison of a novel test for placental alpha microglobulin-1 with fetal fibronectin and cervical length measurement for the prediction of imminent spontaneous preterm delivery in patients with threatened preterm labor
- Does recent sexual intercourse during pregnancy affect the results of the fetal fibronectin rapid test? A comparative prospective study
- Usefulness of maternal serum C-reactive protein with vaginal Ureaplasma urealyticum as a marker for prediction of imminent preterm delivery and chorioamnionitis in patients with preterm labor or preterm premature rupture of membranes
- Effect of blood on ROM diagnosis accuracy of PAMG-1 and IGFBP-1 detecting rapid tests
- Single versus combination tocolytic regimen in the prevention of preterm births in women: a prospective cohort study
- Recommendations of activity restriction in high-risk pregnancy scenarios: a Danish national survey
- Is pharmacologic research on pregnant women with psychoses ethically permissible?
- Women’s knowledge and attitude towards pregnancy in a high-income developing country
- Impact of maternal body mass index on the cesarean delivery rate in Germany from 1990 to 2012
- Justified skepticism about Apgar scoring in out-of-hospital birth settings
- The effect of the use of oxytocin on blood loss during different postpartum periods
- Original articles - Fetus
- The T/QRS ratio values in pregnancies complicated by threatened preterm labour treated with intravenous infusions of fenoterol
- Cardiotocography patterns and risk of intrapartum fetal acidemia
- Combined spinal epidural analgesia for labor using sufentanil epidurally versus intrathecally: a retrospective study on the influence on fetal heart trace
- Original articles - Newborn
- Predicting fetal growth deviation in parous women: combining the birth weight of the previous pregnancy and third trimester ultrasound scan
- Letter to the Editor
- A cerclage is not a modified total cervical occlusion!
- Letter Reply
- Reply to: a cerclage is not a modified Total Cervical Occlusion!
- Congress Calendar
- Congress Calendar
Articles in the same Issue
- Frontmatter
- Editorial
- Erich Saling – The Father of Prenatal and Perinatal Medicine—Dedication to his 90th birthday
- Original articles - Obstetrics
- A transcervical amniotic fluid collector: a new medical device for the assessment of amniotic fluid in patients with ruptured membranes
- Advanced cervical dilatation and spontaneous preterm labor: a comparison between twin and singleton gestations
- Comparison of a novel test for placental alpha microglobulin-1 with fetal fibronectin and cervical length measurement for the prediction of imminent spontaneous preterm delivery in patients with threatened preterm labor
- Does recent sexual intercourse during pregnancy affect the results of the fetal fibronectin rapid test? A comparative prospective study
- Usefulness of maternal serum C-reactive protein with vaginal Ureaplasma urealyticum as a marker for prediction of imminent preterm delivery and chorioamnionitis in patients with preterm labor or preterm premature rupture of membranes
- Effect of blood on ROM diagnosis accuracy of PAMG-1 and IGFBP-1 detecting rapid tests
- Single versus combination tocolytic regimen in the prevention of preterm births in women: a prospective cohort study
- Recommendations of activity restriction in high-risk pregnancy scenarios: a Danish national survey
- Is pharmacologic research on pregnant women with psychoses ethically permissible?
- Women’s knowledge and attitude towards pregnancy in a high-income developing country
- Impact of maternal body mass index on the cesarean delivery rate in Germany from 1990 to 2012
- Justified skepticism about Apgar scoring in out-of-hospital birth settings
- The effect of the use of oxytocin on blood loss during different postpartum periods
- Original articles - Fetus
- The T/QRS ratio values in pregnancies complicated by threatened preterm labour treated with intravenous infusions of fenoterol
- Cardiotocography patterns and risk of intrapartum fetal acidemia
- Combined spinal epidural analgesia for labor using sufentanil epidurally versus intrathecally: a retrospective study on the influence on fetal heart trace
- Original articles - Newborn
- Predicting fetal growth deviation in parous women: combining the birth weight of the previous pregnancy and third trimester ultrasound scan
- Letter to the Editor
- A cerclage is not a modified total cervical occlusion!
- Letter Reply
- Reply to: a cerclage is not a modified Total Cervical Occlusion!
- Congress Calendar
- Congress Calendar
