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Correlation of Cyr61 and CTGF in placentas from the late pre-eclamptic pregnancy
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Xi Chen
Veröffentlicht/Copyright:
10. Januar 2012
Abstract
It is thought that a shallow invasion of the maternal decidua by extravillous trophoblasts (EVT) is associated with the development of pre-eclampsia. Here, we focus on the expression of the proangiogenic proteins Cyr61 and CTGF in the human placenta during normal pregnancy compared with that in the late pre-eclamptic placenta. Cyr61 and CTGF are expressed in the extravillous trophoblast and in endothelial cells. We found the expression of Cyr61 was significantly decreased in pre-eclamptic placentas compared with matched controls. In contrast, the CTGF expression level was upregulated in pre-eclamptic placentas. There was a negative correlation between Cyr61 and CTGF. These results suggest that decreased Cyr61 and overexpressed CTGF may play a part in the development of pre-eclampsia.
Received: 2011-2-23
Revised: 2011-9-9
Accepted: 2011-11-1
Published Online: 2012-01-10
Published in Print: 2012-02-01
©2012 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
CTGF (connective tissue growth factor);
Cyr61 (cysteine-rich 61);
pre-eclampsia
Artikel in diesem Heft
- Review Article
- Cardiac morbidity in twin-twin transfusion syndrome?
- Original Articles – Obstetrics
- Risk factors for postpartum hypertension in women with twin pregnancies
- Serum levels of the adipokine chemerin in preeclampsia
- Expression changes of sex hormone binding globulin in GDM placental tissues
- Evaluation of serum boron levels and lipid profile in pregnancies with or without gestational diabetes
- Racial disparities in maternal hemoglobin concentrations and pregnancy outcomes
- Prediction of imminent preterm delivery in women with preterm premature rupture of membranes
- Endocervical immune mediator production following successful rescue or ultrasound indicated cerclage placement
- Co-ordinate expression of Th1/Th2 phenotypes in maternal and fetal blood: evidence for a transplacental nexus
- Original Articles – Fetus
- How does the duration of active pushing in labor affect neonatal outcomes?
- Quantification of the subcutaneous fat layer with MRI in fetuses of healthy mothers with no underlying metabolic disease vs. fetuses of diabetic and obese mothers
- Original Article – Newborn
- Immediate clinical outcomes in preterm neonates receiving antenatal magnesium for neuroprotection
- Developmental delay in hypoxia-induced HO-1 expression predisposes to gut injury
- Short communication
- Correlation of Cyr61 and CTGF in placentas from the late pre-eclamptic pregnancy
- Letters to the Editor
- Cross-species transfer of group B streptococcus via ingestion?
- WAPM-Newsletter
- WAPM-Newsletter No 1/2012
- Congress Calender
- Congress Calendar
- Prelims
- Prelims
