Serum levels of the adipokine chemerin in preeclampsia
-
Dong-Mei Duan
,
Qiong Lei
Abstract
Objective: Hypothesising that maternal serum chemerin levels may be associated with preeclampsia, we investigated whether maternal serum chemerin levels differ between preeclamptic and healthy pregnant women. We also investigated the association of serum chemerin with metabolic parameters and the severity of the disease.
Methods: This case-control study included 144 women (72 healthy and 72 preeclamptic women) in the third trimester of a singleton pregnancy. Clinical data and maternal serum were collected. The two groups were carefully matched for maternal age and gestational age. The maternal levels of serum chemerin were determined by enzyme-linked immunosorbent assay.
Results: The serum chemerin levels were found to be significantly increased in the women with preeclampsia (258.85±86.64 ng/mL) as compared with the healthy pregnant controls (210.80±47.34 ng/mL) (P<0.001). The serum chemerin concentrations in the severely preeclamptic women (289.6±74.43 ng/mL) were higher than those in the mildly preeclamptic women (228.1±87.99 ng/mL) (P<0.001). A stepwise regression analysis showed that the serum chemerin levels significantly and positively correlated with systolic blood pressure (P<0.001), free fatty acids (P<0.05) and serum creatinine (P<0.01).
Conclusions: Chemerin levels are significantly increased in preeclampsia and independently associated with markers of dyslipidemia and with the severity of the preeclampsia. Further studies need to show the onset of the chemerin increase and its putative involvement in the pathophysiology of preeclampsia.
©2012 by Walter de Gruyter Berlin Boston
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- Congress Calender
- Congress Calendar
- Prelims
- Prelims
Articles in the same Issue
- Review Article
- Cardiac morbidity in twin-twin transfusion syndrome?
- Original Articles – Obstetrics
- Risk factors for postpartum hypertension in women with twin pregnancies
- Serum levels of the adipokine chemerin in preeclampsia
- Expression changes of sex hormone binding globulin in GDM placental tissues
- Evaluation of serum boron levels and lipid profile in pregnancies with or without gestational diabetes
- Racial disparities in maternal hemoglobin concentrations and pregnancy outcomes
- Prediction of imminent preterm delivery in women with preterm premature rupture of membranes
- Endocervical immune mediator production following successful rescue or ultrasound indicated cerclage placement
- Co-ordinate expression of Th1/Th2 phenotypes in maternal and fetal blood: evidence for a transplacental nexus
- Original Articles – Fetus
- How does the duration of active pushing in labor affect neonatal outcomes?
- Quantification of the subcutaneous fat layer with MRI in fetuses of healthy mothers with no underlying metabolic disease vs. fetuses of diabetic and obese mothers
- Original Article – Newborn
- Immediate clinical outcomes in preterm neonates receiving antenatal magnesium for neuroprotection
- Developmental delay in hypoxia-induced HO-1 expression predisposes to gut injury
- Short communication
- Correlation of Cyr61 and CTGF in placentas from the late pre-eclamptic pregnancy
- Letters to the Editor
- Cross-species transfer of group B streptococcus via ingestion?
- WAPM-Newsletter
- WAPM-Newsletter No 1/2012
- Congress Calender
- Congress Calendar
- Prelims
- Prelims
