Endocervical immune mediator production following successful rescue or ultrasound indicated cerclage placement
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Tomi T. Kanninen
Abstract
Objective: Placement of a cervical cerclage at mid-trimester in women at risk for preterm labor is a common procedure with apparent benefits for some women. However, the changes that occur in the cervix following this procedure remain incompletely identified.
Methods: We evaluated the endocervical concentrations of mediators involved in extracellular matrix (ECM) stabilization or degradation prior to, and up to 120 days following, cerclage placement in 53 women who underwent an ultrasound-indicated or a rescue cerclage at 15–25 weeks of gestation due to a cervical length <1.5 cm. All delivered a healthy neonate at term. Samples were tested by enzyme-linked immunosorbent assay for concentrations of hyaluronan (HA), 27 kDa heat shock protein (hsp27), transforming growth factor-β (TGF-β), extracellular matrix metalloproteinase inducer (CD147/EMMPRIN), and matrix metalloproteinase (MMP)-1 and -8.
Results: Concentrations of both HA and hsp27 were highest at the time of cerclage placement and then decreased while TGF-β and EMMPRIN increased in concentration following the procedure. The highest mean EMMPRIN level was measured at >90 days following the procedure while TGF-β levels peaked at 61–90 days post-cerclage. MMP-1 and MMP-8 were not detected over the study time period.
Conclusion: In women with a successful cerclage placement the selective regulation of mediators inhibits progression of ECM degradation and cervical ripening.
©2012 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Review Article
- Cardiac morbidity in twin-twin transfusion syndrome?
- Original Articles – Obstetrics
- Risk factors for postpartum hypertension in women with twin pregnancies
- Serum levels of the adipokine chemerin in preeclampsia
- Expression changes of sex hormone binding globulin in GDM placental tissues
- Evaluation of serum boron levels and lipid profile in pregnancies with or without gestational diabetes
- Racial disparities in maternal hemoglobin concentrations and pregnancy outcomes
- Prediction of imminent preterm delivery in women with preterm premature rupture of membranes
- Endocervical immune mediator production following successful rescue or ultrasound indicated cerclage placement
- Co-ordinate expression of Th1/Th2 phenotypes in maternal and fetal blood: evidence for a transplacental nexus
- Original Articles – Fetus
- How does the duration of active pushing in labor affect neonatal outcomes?
- Quantification of the subcutaneous fat layer with MRI in fetuses of healthy mothers with no underlying metabolic disease vs. fetuses of diabetic and obese mothers
- Original Article – Newborn
- Immediate clinical outcomes in preterm neonates receiving antenatal magnesium for neuroprotection
- Developmental delay in hypoxia-induced HO-1 expression predisposes to gut injury
- Short communication
- Correlation of Cyr61 and CTGF in placentas from the late pre-eclamptic pregnancy
- Letters to the Editor
- Cross-species transfer of group B streptococcus via ingestion?
- WAPM-Newsletter
- WAPM-Newsletter No 1/2012
- Congress Calender
- Congress Calendar
- Prelims
- Prelims
