Home Prediction of imminent preterm delivery in women with preterm premature rupture of membranes
Article
Licensed
Unlicensed Requires Authentication

Prediction of imminent preterm delivery in women with preterm premature rupture of membranes

  • Kyo Hoon Park EMAIL logo , Sung Youn Lee , Shi Nae Kim , Eun Ha Jeong , Kyung Joon Oh and Aeli Ryu
Published/Copyright: November 16, 2011
Journal of Perinatal Medicine
From the journal Volume 40 Issue 2

Abstract

Aims: To develop a model based on non-invasive clinical parameters to predict the probability of imminent preterm delivery (delivery within 48 h) in women with preterm premature rupture of membranes (PPROM), and to determine if additional invasive test results improve the prediction of imminent delivery based on the non-invasive model.

Methods: Transvaginal ultrasonographic assessment of cervical length was performed and maternal serum C-reactive protein (CRP) and white blood cell (WBC) count were determined immediately after amniocentesis in 102 consecutive women with PPROM at 23–33+6 weeks. Amniotic fluid (AF) obtained by amniocentesis was cultured and interleukin-6 (IL-6) levels and WBC counts were determined.

Results: Serum CRP, cervical length, and gestational age were chosen for the non-invasive model (model 1), which has an area under the curve (AUC) of 0.804. When adding AF IL-6 as an invasive marker to the non-invasive model, serum CRP was excluded from the final model (model 2) as not significant, whereas AF IL-6, cervical length, and gestational age remained in model 2. No significant difference in AUC was found between models 1 and 2.

Conclusions: The non-invasive model based on cervical length, gestational age, and serum CRP is highly predictive of imminent delivery in women with PPROM. However, invasive test results did not add predictive information to the non-invasive model in this setting.

Keywords: Amniotic fluid interleukin-6; cervical length; non-invasive model; preterm delivery; preterm PROM
Corresponding author: Kyo Hoon Park, MD, PhD Department of Obstetrics and Gynecology Seoul National University Bundang Hospital, 300 Gumi-dong Bundang-gu, Seongnam-si Gyeonggi-do, 463-707 Korea Tel.: +82-31-787-7252 Fax: +82-31-787-4054
Received: 2011-8-10
Revised: 2011-9-4
Accepted: 2011-10-19
Published Online: 2011-11-16
Published in Print: 2012-02-01

©2012 by Walter de Gruyter Berlin Boston

Articles in the same Issue

  1. Review Article
  2. Cardiac morbidity in twin-twin transfusion syndrome?
  3. Original Articles – Obstetrics
  4. Risk factors for postpartum hypertension in women with twin pregnancies
  5. Serum levels of the adipokine chemerin in preeclampsia
  6. Expression changes of sex hormone binding globulin in GDM placental tissues
  7. Evaluation of serum boron levels and lipid profile in pregnancies with or without gestational diabetes
  8. Racial disparities in maternal hemoglobin concentrations and pregnancy outcomes
  9. Prediction of imminent preterm delivery in women with preterm premature rupture of membranes
  10. Endocervical immune mediator production following successful rescue or ultrasound indicated cerclage placement
  11. Co-ordinate expression of Th1/Th2 phenotypes in maternal and fetal blood: evidence for a transplacental nexus
  12. Original Articles – Fetus
  13. How does the duration of active pushing in labor affect neonatal outcomes?
  14. Quantification of the subcutaneous fat layer with MRI in fetuses of healthy mothers with no underlying metabolic disease vs. fetuses of diabetic and obese mothers
  15. Original Article – Newborn
  16. Immediate clinical outcomes in preterm neonates receiving antenatal magnesium for neuroprotection
  17. Developmental delay in hypoxia-induced HO-1 expression predisposes to gut injury
  18. Short communication
  19. Correlation of Cyr61 and CTGF in placentas from the late pre-eclamptic pregnancy
  20. Letters to the Editor
  21. Cross-species transfer of group B streptococcus via ingestion?
  22. WAPM-Newsletter
  23. WAPM-Newsletter No 1/2012
  24. Congress Calender
  25. Congress Calendar
  26. Prelims
  27. Prelims
https://doi.org/10.1515/jpm.2011.124
Keywords for this article
Amniotic fluid interleukin-6; cervical length; non-invasive model; preterm delivery; preterm PROM

Articles in the same Issue

  1. Review Article
  2. Cardiac morbidity in twin-twin transfusion syndrome?
  3. Original Articles – Obstetrics
  4. Risk factors for postpartum hypertension in women with twin pregnancies
  5. Serum levels of the adipokine chemerin in preeclampsia
  6. Expression changes of sex hormone binding globulin in GDM placental tissues
  7. Evaluation of serum boron levels and lipid profile in pregnancies with or without gestational diabetes
  8. Racial disparities in maternal hemoglobin concentrations and pregnancy outcomes
  9. Prediction of imminent preterm delivery in women with preterm premature rupture of membranes
  10. Endocervical immune mediator production following successful rescue or ultrasound indicated cerclage placement
  11. Co-ordinate expression of Th1/Th2 phenotypes in maternal and fetal blood: evidence for a transplacental nexus
  12. Original Articles – Fetus
  13. How does the duration of active pushing in labor affect neonatal outcomes?
  14. Quantification of the subcutaneous fat layer with MRI in fetuses of healthy mothers with no underlying metabolic disease vs. fetuses of diabetic and obese mothers
  15. Original Article – Newborn
  16. Immediate clinical outcomes in preterm neonates receiving antenatal magnesium for neuroprotection
  17. Developmental delay in hypoxia-induced HO-1 expression predisposes to gut injury
  18. Short communication
  19. Correlation of Cyr61 and CTGF in placentas from the late pre-eclamptic pregnancy
  20. Letters to the Editor
  21. Cross-species transfer of group B streptococcus via ingestion?
  22. WAPM-Newsletter
  23. WAPM-Newsletter No 1/2012
  24. Congress Calender
  25. Congress Calendar
  26. Prelims
  27. Prelims
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2025 De Gruyter Brill
Downloaded on 12.11.2025 from https://www.degruyterbrill.com/document/doi/10.1515/jpm.2011.124/html
Scroll to top button