Co-ordinate expression of Th1/Th2 phenotypes in maternal and fetal blood: evidence for a transplacental nexus
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Doris B. Tse
Abstract
If maternal atopy and environmental exposure affect prenatal Th cell development, the maternal and fetal immune systems should display common Th1/Th2 phenotypes. To test this hypothesis, we studied maternal and neonatal blood samples from mothers with total serum IgE <300 IU/mL. Basal levels of IFN-γ, IL-4, and eotaxin in paired maternal and fetal sera were tightly correlated. Polyclonal T cell activation in vitro by Staphylococcal exotoxin B induced co-ordinate IFN-γ production from paired maternal and fetal mononuclear cells, accompanied by co-ordinate increases in activated CD4+CD69+ cells that display the CCR4+Th2 and CXCR3+ Th1 phenotypes. Maternal and fetal CD4+CXCR3+ T cells were subsequently identified as the major producers of IFN-γ. The data established that a transplacental nexus exists during normal pregnancy and that fetal Th cell responses may be biased by the maternal immune system.
©2012 by Walter de Gruyter Berlin Boston
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- Serum levels of the adipokine chemerin in preeclampsia
- Expression changes of sex hormone binding globulin in GDM placental tissues
- Evaluation of serum boron levels and lipid profile in pregnancies with or without gestational diabetes
- Racial disparities in maternal hemoglobin concentrations and pregnancy outcomes
- Prediction of imminent preterm delivery in women with preterm premature rupture of membranes
- Endocervical immune mediator production following successful rescue or ultrasound indicated cerclage placement
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- Original Articles – Fetus
- How does the duration of active pushing in labor affect neonatal outcomes?
- Quantification of the subcutaneous fat layer with MRI in fetuses of healthy mothers with no underlying metabolic disease vs. fetuses of diabetic and obese mothers
- Original Article – Newborn
- Immediate clinical outcomes in preterm neonates receiving antenatal magnesium for neuroprotection
- Developmental delay in hypoxia-induced HO-1 expression predisposes to gut injury
- Short communication
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- Letters to the Editor
- Cross-species transfer of group B streptococcus via ingestion?
- WAPM-Newsletter
- WAPM-Newsletter No 1/2012
- Congress Calender
- Congress Calendar
- Prelims
- Prelims
Articles in the same Issue
- Review Article
- Cardiac morbidity in twin-twin transfusion syndrome?
- Original Articles – Obstetrics
- Risk factors for postpartum hypertension in women with twin pregnancies
- Serum levels of the adipokine chemerin in preeclampsia
- Expression changes of sex hormone binding globulin in GDM placental tissues
- Evaluation of serum boron levels and lipid profile in pregnancies with or without gestational diabetes
- Racial disparities in maternal hemoglobin concentrations and pregnancy outcomes
- Prediction of imminent preterm delivery in women with preterm premature rupture of membranes
- Endocervical immune mediator production following successful rescue or ultrasound indicated cerclage placement
- Co-ordinate expression of Th1/Th2 phenotypes in maternal and fetal blood: evidence for a transplacental nexus
- Original Articles – Fetus
- How does the duration of active pushing in labor affect neonatal outcomes?
- Quantification of the subcutaneous fat layer with MRI in fetuses of healthy mothers with no underlying metabolic disease vs. fetuses of diabetic and obese mothers
- Original Article – Newborn
- Immediate clinical outcomes in preterm neonates receiving antenatal magnesium for neuroprotection
- Developmental delay in hypoxia-induced HO-1 expression predisposes to gut injury
- Short communication
- Correlation of Cyr61 and CTGF in placentas from the late pre-eclamptic pregnancy
- Letters to the Editor
- Cross-species transfer of group B streptococcus via ingestion?
- WAPM-Newsletter
- WAPM-Newsletter No 1/2012
- Congress Calender
- Congress Calendar
- Prelims
- Prelims
