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Central precocious puberty after interpersonal transfer of testosterone gel: just a coincidence?
-
Cécile Brachet
and
Claudine Heinrichs
Published/Copyright:
July 13, 2012
Abstract
Background: Over the last 10 years, several children, fetuses and women have been reported to be virilized through interpersonal transfer of testosterone (T) gel used by fathers or partners. Long-term exposure to androgens in children, such as in poorly controlled congenital adrenal hyperplasia, is known to promote central precocious puberty.
Methods: Clinical case report.
Results: We report on a 5-year-old boy who developed central precocious puberty after long-term (starting prenatally) exposure to testosterone through interpersonal transfer of T gel used by his father. We also report on another case illustrating that the recommended precautions are not sufficient to avoid interpersonal transfer of T gel among household contacts. Plasma testosterone levels and history-taking revealed the cause of virilisation and the testosterone contamination source in both cases. Given the increased testicular volume and persisting testosterone elevation after cessation of gel use in the first patient, a GnRH test was carried out and confirmed central precocious puberty.
Conclusion: This is the first report of a boy with central precocious puberty occurring after long-term (starting prenatally) exposure to testosterone through the interpersonal transfer of T gel. This report questions whether central precocious puberty constitutes a long-term side effect of testosterone exposure in childhood through T gel use by a household contact.
Keywords: central precocious puberty; children’s virilization; testosterone contamination; testosterone gel; testosterone gel interpersonal transfer
Received: 2012-3-7
Accepted: 2012-5-17
Published Online: 2012-07-13
Published in Print: 2012-08-01
©2012 by Walter de Gruyter Berlin Boston
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Keywords for this article
central precocious puberty;
children’s virilization;
testosterone contamination;
testosterone gel;
testosterone gel interpersonal transfer
Articles in the same Issue
- Masthead
- Masthead
- Editorial
- Obesity, adolescence, and sleep deprivation
- Reviews
- 18F-DOPA positron emission tomography/computed tomography application in congenital hyperinsulinism
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