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Is the growth outcome of children with idiopathic short stature and isolated growth hormone deficiency following treatment with growth hormone and a luteinizing hormone-releasing hormone agonist superior to that obtained by GH alone?
-
Ana Colmenares
,
Laura González
Veröffentlicht/Copyright:
26. Juli 2012
Abstract
Aim: The aim of this study was to evaluate the effect of combined therapy with growth hormone (GH) and luteinizing hormone-releasing hormone agonist (LHRHa) on the near-final height (NFH) of children with idiopathic short stature (ISS) and growth hormone deficiency (GHD) in early puberty.
Methods: A retrospective analysis of 20 patients with ISS and 9 patients with GHD treated with combined therapy was undertaken. Twelve children with ISS and ten with GHD, treated with GH alone, served as controls. Patients were matched at baseline for chronological age, bone age, height standard deviation score (SDS), and pubertal development.
Results: Patients with ISS or GHD treated with combined therapy improved both their predicted adult height (PAH) at 2 years of therapy (ISS, p<0.001; GHD, p=0.03) and their NFH (ISS, p<0.05; GHD, p=0.05). Treatment with combined therapy did not generate additional benefits on the PAH after 2 years of therapy (ISS children, an increase of 7.9±4.9 cm with combined therapy vs. 7.3±6.0 cm with GH; GHD children, an increase of 6.8±7.8 cm with combined therapy vs. 5±5.9 cm with GH). The total height gain SDS was higher in patients treated with GH alone compared with those with combined therapy, but the difference was not significant (ISS children, a gain of 2.4 SDS with GH vs. 0.8 SDS with combined therapy; GHD children, a gain of 1.8 SDS with GH vs. 0.6 SDS with combined therapy).
Conclusions: Although 2 years of combined treatment with GH and LHRHa improved the PAH and the NFH of ISS and GHD patients in early puberty, this improvement was not significant compared with that observed in similar subjects treated with GH alone.
Keywords: growth hormone (GH); growth hormone deficiency (GHD); idiopathic short stature (ISS); luteinizing hormone-releasing hormone agonist (LHRHa); near-final height
Received: 2012-6-10
Accepted: 2012-6-23
Published Online: 2012-07-26
Published in Print: 2012-08-01
©2012 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
growth hormone (GH);
growth hormone deficiency (GHD);
idiopathic short stature (ISS);
luteinizing hormone-releasing hormone agonist (LHRHa);
near-final height
Artikel in diesem Heft
- Masthead
- Masthead
- Editorial
- Obesity, adolescence, and sleep deprivation
- Reviews
- 18F-DOPA positron emission tomography/computed tomography application in congenital hyperinsulinism
- Pathogenesis of propylthiouracil-related hepatotoxicity in children: present concepts
- Images in pediatric endocrinology
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- Original articles
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- Overestimation of final height prediction in patients with classical congenital adrenal hyperplasia using the Bayley and Pinneau method
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- Molecular defects of the GnRH-receptor gene in Chinese patients with idiopathic hypogonadotropic hypogonadism and the severity of hypogonadism
- Association of vitamin D receptor gene Cdx2 polymorphism with bone markers in Turner syndrome patients
- Serum 25-hydroxyvitamin D levels do not correlate with asthma severity in a case-controlled study of children and adolescents
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- Nesfatin-1 in newborns: relationship with endocrine and metabolic and anthropometric measures
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