Association of vitamin D receptor gene Cdx2 polymorphism with bone markers in Turner syndrome patients
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María Peralta López
, Viviana Centeno , Mirta Miras , Liliana Silvano , Adriana Pérez, , Liliana Muñoz , Gabriela Sobrero , María Ulla and Nori Tolosa de Talamoni
Abstract
Background: Turner syndrome (TS) patients usually have low bone mineral density (BMD) and increased risk of osteoporotic fractures. We have previously demonstrated an association of bb (BsmI polymorphic site) and ff (FokI polymorphic site) vitamin D receptor (VDR) genotypes with reduced BMD in TS patients.
Aim: To analyze the relationship between VDR-Cdx2 polymorphism and BMD as well as bone metabolic variables in TS patients.
Methods: Fifty-five TS patients and 59 control women were studied. VDR-Cdx2 genotypes were determined using TaqMan probes in a real time thermocycler. Lumbar and femoral BMD were determined by dual-energy X-ray absorptiometry (DEXA) and serum intact parathyroid hormone, osteocalcin and β-CrossLaps were determined by electrochemiluminescence.
Results: Patients with genotype GG had higher levels of both osteocalcin and β-CrossLaps as compared to patients with genotype GA (p<0.01 and p<0.05, respectively).
Conclusion: Patients carrying genotype GG have higher levels of bone formation and resorption markers. This indicates a more active bone turnover that could impact on their future bone mineral density.
©2012 by Walter de Gruyter Berlin Boston
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- Masthead
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- Editorial
- Obesity, adolescence, and sleep deprivation
- Reviews
- 18F-DOPA positron emission tomography/computed tomography application in congenital hyperinsulinism
- Pathogenesis of propylthiouracil-related hepatotoxicity in children: present concepts
- Images in pediatric endocrinology
- Adhesion of the labia minora in girls: a common disorder that is rarely considered
- Original articles
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- Effects of selenium supplementation in the early stage of autoimmune thyroiditis in childhood: an open-label pilot study
- Overestimation of final height prediction in patients with classical congenital adrenal hyperplasia using the Bayley and Pinneau method
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- The association of FGF23 levels in obese adolescents with insulin sensitivity
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- Nesfatin-1 in newborns: relationship with endocrine and metabolic and anthropometric measures
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- A novel mutation in the GCM2 gene causing severe congenital isolated hypoparathyroidism
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- The histopathological effects of tamoxifen in the treatment of pubertal gynecomastia
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- Foster care and type 1 diabetes in the Bronx: a case series
- Primary hyperparathyroidism: fifth parathyroid intrathymic adenoma in a young patient
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