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Association analysis between endothelial function related factors and coronary artery stenosis degree in coronary heart disease patients with type 2 diabetes mellitus
-
Quanmin Li
,
Zhifang Zhang
Published/Copyright:
July 13, 2012
Abstract
Objective: To investigate the relationship between soluble intercellular adhesion molecule (sICAM-1), vascular endothelial cell adhesion molecule (VCAM-1), monocytes chemotactic protein (MCP-1), von Willebrand factor (vWF), and coronary artery stenoses degree in coronary heart disease (CHD) within type 2 diabetes mellitus (T2DM) patients.
Methods: A total of 92 subjects were treated with coronary angiography (CAG), including 62 subjects with CHD. The individuals were divided into three groups, group A (32 patients with CHD and T2DM), group B (30 patients with CHD but no T2DM) and group C (30 patients with no CHD and T2DM). All patients were treated with a Gensini coronary angiography check. The correlations between sICAM-1, VCAM-1, MCP-1 and vWF in peripheral blood and coronary artery stenosis degree were analyzed.
Results: The average score of coronary artery stenosis degree was 30.75±12.67 in group A, which was significantly higher than group B (11.20±7.51) and group C (2.40±1.23) (p<0.01). The mean levels of sICAM-1, VCAM-1, MCP-1 and vWF in serum showed that group A was significantly higher than group B and group C (p<0.01), and also that group B was higher than group C. There were significant positive correlations between the degree of coronary artery stenosis and the mean level of sICAM-1, VCAM-1, MCP-1, vWF in group A (p<0.01), but these were not shown in group B and group C (p>0.05).
Conclusions: Association analysis shown that the level of sICAM-1, VCAM-1, MCP-1 and vWF elevated in CHD with T2DM patients. Vascular endothelial dysfunction could be caused to the coronary artery stenosis pathophysiological process. Results from this study suggested that sICAM-1, VCAM-1, MCP-1 and vWF may contribute to the occurrence and development of vascular lesions in T2DM. These endothelial function related factors could be acceptable as a prediction and testing index of vascular complications in T2DM.
Keywords: cell adhesion molecule 1; coronary angiography; coronary heart disease; nonocyte chemotactic protein 1; soluble intercellular vascular cell adhesion molecule 1; type 2 diabetes mellitus; von Willebrand factor
Received: 2012-5-16
Accepted: 2012-6-3
Published Online: 2012-07-13
Published in Print: 2012-08-01
©2012 by Walter de Gruyter Berlin Boston
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