Abstract
Aim: The aim of the study was to evaluate the role of selenium (Se) in childhood autoimmune thyroiditis regarding its effect on thyroid-stimulating hormone (TSH), free thyroxine (fT4), thyroid peroxidase antibodies (TPOAb), thyroglobulin antibody (TgAb), and thyroid morphology.
Methods: Newly diagnosed 23 euthyroid children (mean age, 12.3±2.4 years) with Hashimoto thyroiditis (HT) received only 50 μg L-selenomethionine per day for 3 months. The baseline basal urinary iodine level, serum Se, TSH, fT4, TPOAb, and TgAb concentrations, and thyroid morphology by ultrasound were detected. We reanalyzed the TPOAb and TgAb changes at the 3rd month and then compared the thyroid morphology with 30 healthy individuals (mean age, 12.1±2.1 years) at the 6th month.
Results: Serum TPOAb, TgAb, and thyroid echogenicity were unchanged with Se supplementation. A prominent decrease in thyroid volume was noteworthy; 35% of patients showed a thyroid volume regression rate of ≥30%.
Conclusion: In terms of TPOAb and TgAb, Se may not benefit in the euthyroid period of HT, but Se supplementation seems to lead a favorable response in thyroid volume regression.
©2012 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Masthead
- Masthead
- Editorial
- Obesity, adolescence, and sleep deprivation
- Reviews
- 18F-DOPA positron emission tomography/computed tomography application in congenital hyperinsulinism
- Pathogenesis of propylthiouracil-related hepatotoxicity in children: present concepts
- Images in pediatric endocrinology
- Adhesion of the labia minora in girls: a common disorder that is rarely considered
- Original articles
- Thyroid nodules in children and adolescents: a single institution’s experience
- Effects of selenium supplementation in the early stage of autoimmune thyroiditis in childhood: an open-label pilot study
- Overestimation of final height prediction in patients with classical congenital adrenal hyperplasia using the Bayley and Pinneau method
- Is the growth outcome of children with idiopathic short stature and isolated growth hormone deficiency following treatment with growth hormone and a luteinizing hormone-releasing hormone agonist superior to that obtained by GH alone?
- Molecular defects of the GnRH-receptor gene in Chinese patients with idiopathic hypogonadotropic hypogonadism and the severity of hypogonadism
- Association of vitamin D receptor gene Cdx2 polymorphism with bone markers in Turner syndrome patients
- Serum 25-hydroxyvitamin D levels do not correlate with asthma severity in a case-controlled study of children and adolescents
- Assessment of the 21-hydroxylase deficiency and the adrenal functions in young females with Turner syndrome
- The association of FGF23 levels in obese adolescents with insulin sensitivity
- Higher postprandial serum ghrelin among African-American girls before puberty
- Metabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescents
- The second report from Turkey: waist percentiles for 6–11-year-old children in Elazig Province, Eastern Anatolia
- Association analysis between endothelial function related factors and coronary artery stenosis degree in coronary heart disease patients with type 2 diabetes mellitus
- Adiponectin and arterial stiffness in youth with type 1 diabetes: the SEARCH for Diabetes in Youth Study
- Thyroid autoimmunity in 72 children with type 1 diabetes mellitus: relationship with pancreatic autoimmunity and child growth
- Nesfatin-1 in newborns: relationship with endocrine and metabolic and anthropometric measures
- How much is enough? Evaluation of adrenal function in children who undergo growth hormone stimulation test
- A novel mutation in the GCM2 gene causing severe congenital isolated hypoparathyroidism
- Relation among ghrelin, nutritional status, and immunity in children
- The histopathological effects of tamoxifen in the treatment of pubertal gynecomastia
- Patient reports
- Central precocious puberty after interpersonal transfer of testosterone gel: just a coincidence?
- Elevated α-fetoprotein levels in Van Wyk-Grumbach syndrome: a case report and review of literature
- Identification of LDLR mutations in two Chinese pedigrees with familial hypercholesterolemia
- Foster care and type 1 diabetes in the Bronx: a case series
- Primary hyperparathyroidism: fifth parathyroid intrathymic adenoma in a young patient
- Sturge-Weber syndrome: presentation with partial hypopituitarism
- Self-limiting hematuria following growth hormone provocative testing with arginine hydrochloride
- First case report of short-chain acyl-CoA dehydrogenase deficiency in China
- Ganglioneuroblastoma in a young child with Turner syndrome
- MODY2 caused by a novel mutation of GCK gene
- Variability in the age at diagnosis of diabetes in two unrelated patients with a homozygous glucokinase gene mutation
- Letter to the editor
- Understanding less than nothing: high-dose vitamin D therapy for treating vitamin D deficiency
- Meetings
- Meetings Calendar
Articles in the same Issue
- Masthead
- Masthead
- Editorial
- Obesity, adolescence, and sleep deprivation
- Reviews
- 18F-DOPA positron emission tomography/computed tomography application in congenital hyperinsulinism
- Pathogenesis of propylthiouracil-related hepatotoxicity in children: present concepts
- Images in pediatric endocrinology
- Adhesion of the labia minora in girls: a common disorder that is rarely considered
- Original articles
- Thyroid nodules in children and adolescents: a single institution’s experience
- Effects of selenium supplementation in the early stage of autoimmune thyroiditis in childhood: an open-label pilot study
- Overestimation of final height prediction in patients with classical congenital adrenal hyperplasia using the Bayley and Pinneau method
- Is the growth outcome of children with idiopathic short stature and isolated growth hormone deficiency following treatment with growth hormone and a luteinizing hormone-releasing hormone agonist superior to that obtained by GH alone?
- Molecular defects of the GnRH-receptor gene in Chinese patients with idiopathic hypogonadotropic hypogonadism and the severity of hypogonadism
- Association of vitamin D receptor gene Cdx2 polymorphism with bone markers in Turner syndrome patients
- Serum 25-hydroxyvitamin D levels do not correlate with asthma severity in a case-controlled study of children and adolescents
- Assessment of the 21-hydroxylase deficiency and the adrenal functions in young females with Turner syndrome
- The association of FGF23 levels in obese adolescents with insulin sensitivity
- Higher postprandial serum ghrelin among African-American girls before puberty
- Metabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescents
- The second report from Turkey: waist percentiles for 6–11-year-old children in Elazig Province, Eastern Anatolia
- Association analysis between endothelial function related factors and coronary artery stenosis degree in coronary heart disease patients with type 2 diabetes mellitus
- Adiponectin and arterial stiffness in youth with type 1 diabetes: the SEARCH for Diabetes in Youth Study
- Thyroid autoimmunity in 72 children with type 1 diabetes mellitus: relationship with pancreatic autoimmunity and child growth
- Nesfatin-1 in newborns: relationship with endocrine and metabolic and anthropometric measures
- How much is enough? Evaluation of adrenal function in children who undergo growth hormone stimulation test
- A novel mutation in the GCM2 gene causing severe congenital isolated hypoparathyroidism
- Relation among ghrelin, nutritional status, and immunity in children
- The histopathological effects of tamoxifen in the treatment of pubertal gynecomastia
- Patient reports
- Central precocious puberty after interpersonal transfer of testosterone gel: just a coincidence?
- Elevated α-fetoprotein levels in Van Wyk-Grumbach syndrome: a case report and review of literature
- Identification of LDLR mutations in two Chinese pedigrees with familial hypercholesterolemia
- Foster care and type 1 diabetes in the Bronx: a case series
- Primary hyperparathyroidism: fifth parathyroid intrathymic adenoma in a young patient
- Sturge-Weber syndrome: presentation with partial hypopituitarism
- Self-limiting hematuria following growth hormone provocative testing with arginine hydrochloride
- First case report of short-chain acyl-CoA dehydrogenase deficiency in China
- Ganglioneuroblastoma in a young child with Turner syndrome
- MODY2 caused by a novel mutation of GCK gene
- Variability in the age at diagnosis of diabetes in two unrelated patients with a homozygous glucokinase gene mutation
- Letter to the editor
- Understanding less than nothing: high-dose vitamin D therapy for treating vitamin D deficiency
- Meetings
- Meetings Calendar